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Cortical Development
This book reviews recent progress in cortical development research, focusing on the mechanisms of neural stem cell regulation, neuronal diversity and connectivity formation, and neocortical organization. Development of the cerebral cortex, the center for higher brain functions such as cognition, memory, and decision making, is one of the major targets of current research. The cerebral cortex is divided into many areas, including motor, sensory, and visual cortices, each of which consists of six layers containing a variety of neurons with different activities and connections. As this book explains, such diversity in neuronal types and connections is generated at various levels. First, neural stem cells change their competency over time, giving sequential rise to distinct types of neurons and glial cells: initially deep layer neurons, then superficial layer neurons, and lastly astrocytes. The activities and connections of neurons are further modulated via interactions with other brain regions, such as the thalamocortical circuit, and via input from the environment. This book on cortical development is essential reading for students, postdocs, and neurobiologists.
Non-humans in Social Science
The book explores the issue of non-humans and their role and position within contemporary social sciences. Inspired by current trends of bridging the dichotomy of nature and culture, the authors use the “non-human“ as a prism that offers a different perspective of the world, society, culture, and last but not least, being(s). To start paying attention to non-humans has the potential to hybridize social sciences and in turn enrich them as well as to offer social scientists novel perspectives and tools to approach social phenomena. Such an attitude might in turn lead to a reassessment of understanding of the relationship between the world and being, and of the categories of being and subje...
Chemical Factors in Neural Growth, Degeneration and Repair
This volume provides an up-to-date survey of current thinking concerning the actions of chemical factors in the regulation of neuronal behaviour under normal and pathological conditions. The book is divided into four sections, dealing with chemical factors involved with the formation of axon pathways, factors involved with neuronal survival and specialization during normal development, factors involved in normal maintenance and repair of adult neurons and, finally, factors that have been implicated as mediators of degenerative changes in neurological and neuropsychiatric disorders.
The Claustrum: charting a way forward for the brain’s most mysterious nucleus
The claustrum is a long, band-like grey matter structure situated in the ventrolateral telencephalon of most, if not all, mammalian brains. Due to its shape and close proximity to white matter structures and insular cortex, the anatomy and behavioral relevance of the claustrum have proven difficult to study. As a result, disagreements in the literature exist over ontogeny, phylogeny, anatomical boundaries, and connectivity. Despite this, it is generally regarded that the claustrum contains excitatory projection neurons that reciprocally connect to most regions of the cerebral cortex, a feature that has fostered varying hypotheses as to its function. These hypotheses propose multisensory integration, coordination of cortical activity for the generation of conscious percepts, or saliency filtration. The articles of this e-book consider the historical and recent highlights in claustrum structure, hodology, and function and seek to provide a compelling way forward for this “hidden” nucleus.
Further Understanding of Serotonin 7 Receptors’ Neuro-Psycho-Pharmacology
Within the CNS and in the periphery, serotonin (5-HT) participates in a number of functions including cognition, mood, sleep-wake rhythms, intestinal inflammation. 5-HT receptors can be classified into at least seven classes, designated 5-HT1 to 5-HT7. Since its identification, the 5-HT7 receptor has been the subject of intense research efforts, driven by its presence in functionally-relevant brain regions and in the gut. The availability of selective agonists and antagonists, in combination with genetically-modified mice lacking 5-HT7 receptors, has allowed so far a better understanding about the patho-physiological roles of this receptor. This Topic will review the state-of-the-art from st...
Neuromodulation of Executive Circuits
High-order executive tasks involve the interplay between frontal cortex and other cortical and subcortical brain regions. In particular, the frontal cortex, striatum and thalamus interact via parallel fronto-striatal "loops" that are crucial for the executive control of behavior. In all of these brain regions, neuromodulatory inputs (e.g. serotonergic, dopaminergic, cholinergic, adrenergic, and peptidergic afferents) regulate neuronal activity and synaptic transmission to optimize circuit performance for specific cognitive demands. Indeed, dysregulation of neuromodulatory input to fronto-striatal circuits is implicated in a number of neuropsychiatric disorders, such as schizophrenia, depress...
Economy and Disability
Society has developed so that it accommodates the needs of intertwined people, but a question arises as to which people have been accommodated. Has everyone been taken care of in an equal manner? If not, who has fallen into the gap between the institutions that are supposed to accommodate them? This book is a study of these issues of economy and disability using game theory, which has provided a means of analyzing various social phenomena. Part I provides actual cases related to economy and disability, with the stories based on interviews by the author. Part II is geared toward a game theoretic analysis. This book explains disability-related issues by game theory and innovates that theory by...
Integrative and Molecular Approach to Brain Function
Hardbound. The present advancement in the brain is characterized by the dichotomy of the molecular approaches to cellular functions in the brain and integrative approaches to the mechanisms of brain functions. This book contains the proceedings of the Uehera Foundation Symposium held in 1996 in Tokyo, which aimed to synthesize the two lines of approaches.The major research strategy employed at the molecular and cellular levels is to pinpoint a molecule, a set of them, a microstructure which is responsible for a cellular function. That undertaken at integrative and functional levels is to comprehend the mechanisms which underlie a system function of the brain. These two strategies will be mutually beneficial, and the need to combine them in brain science will become increasingly important. This monograph, thus, helps envision the future of brain science and is of great interest to researchers, graduate and undergraduate students who want to know the cur
