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The Autisms
The science of autism has seen tremendous breakthroughs in the past few decades. A multitude of relatively rare mutations have been identified to explain around 15 % of autism cases with many of these genetic causes systematically examined in animal models. This marriage of human genetics and basic neurobiology has led to major advances in our understanding of how these genetic mutations alter brain function and help to better understand the human disease. These scientific approaches are leading to the identification of potential therapeutic targets for autism that can be tested in the very same genetic models and hopefully translated into novel, rational therapies. The Autisms: Molecules to Model Systems provides a roadmap to many of these genetic causes of autism and clarifies what is known at the molecular, cellular, and circuit levels. Focusing on tractable genetic findings in human autism and painstakingly dissecting the underlying neurobiology, the book explains, is the key to understanding the pathophysiology of autism and ultimately to identifying novel treatments.
The Bookseller
Official organ of the book trade of the United Kingdom.
Publisher and Bookseller
Vols. for 1871-76, 1913-14 include an extra number, The Christmas bookseller, separately paged and not included in the consecutive numbering of the regular series.
Exquisite Weddings
Exquisite Weddings is a publication that understands a wedding should be as unforgettably unique as the couple getting married. Our goal is to inspire brides, and within the pages of our magazine, we bring together a powerful ensemble of luxury experience, engaging the dreamer and the romantic.
FCC Record
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Origami Birds
This compilation of 34 original models by origami master John Montroll offers folders illustrated directions for creating a fabulous array of avian creatures. Ranging in difficulty from intermediate to complex, the figures include a hen, chick, and rooster; waterfowl such as a duck, heron, and swan; and other wild and domesticated birds.
Shake Loose the Border
The war is coming to an end... Now the fighting can really start. The thrilling conclusion to Robert Low’s epic and savage Border Reivers Trilogy It is 1548, and the war with the English is winding down. But in the savage heart of the Borders, peace is far from secured. One-armed Batty Coalhouse, bounty hunter, explosives specialist, border wanderer, is doing what he usually does: ripping the enemy apart. But then he’s sent on an unusual errand. An old friend has been taken to Berwick, England’s northernmost point. Batty needs to get him back. Nothing is ever simple on the Border, and soon Batty is fighting enemies old and new. But in this blood-soaked world, it’s not just your enemies you need to worry about... Hold tight for a last, wild ride. An unforgettable novel from a unique historical imagination, Shake Loose The Border will blow you away.
Statistics and Data Visualization in Climate Science with R and Python
A comprehensive overview of essential statistical concepts, useful statistical methods, data visualization, and modern computing tools for the climate sciences and many others such as geography and environmental engineering. It is an invaluable reference for students and researchers in climatology and its connected fields who wish to learn data science, statistics, R and Python programming. The examples and exercises in the book empower readers to work on real climate data from station observations, remote sensing and simulated results. For example, students can use R or Python code to read and plot the global warming data and the global precipitation data in netCDF, csv, txt, or JSON; and compute and interpret empirical orthogonal functions. The book's computer code and real-world data allow readers to fully utilize the modern computing technology and updated datasets. Online supplementary resources include R code and Python code, data files, figure files, tutorials, slides and sample syllabi.
Bulletin
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