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Innovations in Development, Translational Research and Manufacturing of CAR T cells
Immunotherapy with genetically engineered immune cell products is a transformative treatment modality with potential applications in various fields of medicine. A prime example is chimeric antigen receptor (CAR)-modified T cells in hematology and oncology, and the advent of CAR T cell therapies to treat infectious diseases, autoimmune disorders, and cardiovascular diseases. The medical need and demand from patients and caregivers require radical innovations to accelerate and improve pre-clinical development and clinical translation, provision of gene-transfer vectors, and immune cell product manufacturing as well as a critical reflection and discussion on ethical and socioeconomic aspects. T...
The Sicarii in Josephus's Judean War
This book offers a comprehensive study of the Sicarii in Josephus's Judean War. Detailed rhetorical analyses are provided not only for the Masada narrative, where Josephus tells how the Sicarii famously committed suicide, but also for all other places in War where their activities are described or must be inferred from the context. The study shows how Josephus adopted the Sicarii in his narrative to develop and bring to a resolution several major themes in War. In a departure from the classical proposal that the Sicarii were an armed and fanatical off-shoot of the Zealots, this work concludes that from a historical perspective, "Sicarii" was a somewhat fluid term used to describe Jews of the Judean revolt who were associated with acts of violence against their own people for religious/political ends.
Epilepsy Surgery
The thoroughly revised and updated Second Edition of this landmark work is the most comprehensive and current reference on the surgical treatment of the epilepsies. More than 100 invited experts from around the world present a global view of contemporary approaches to presurgical evaluation, surgical treatment, and postsurgical assessment. This edition provides detailed information on the vital role of structural and functional neuroimaging in presurgical evaluation and surgical planning. Noted experts offer up-to-date patient selection guidelines and explain current concepts of intractability. The book details the most effective surgical techniques, presents extensive data on surgical outcome, and discusses strategies for preventing and managing complications. More than 500 illustrations complement the text. An appendix section includes protocols and outcome statistics from over 50 leading epilepsy surgery centers.
Handbook of Neural Engineering
An important new work establishing a foundation for future developments in neural engineering The Handbook of Neural Engineering provides theoretical foundations in computational neural science and engineering and current applications in wearable and implantable neural sensors/probes. Inside, leading experts from diverse disciplinary groups representing academia, industry, and private and government organizations present peer-reviewed contributions on the brain-computer interface, nano-neural engineering, neural prostheses, imaging the brain, neural signal processing, the brain, and neurons. The Handbook of Neural Engineering covers: Neural signal and image processing--the analysis and model...
Puzzling Cases of Epilepsy
Epilepsy is one of the most common neurological disorders, and original observations in the field are often the key to diagnosis and successful treatment. Physicians new to the field as well as seasoned practitioners will benefit from more than one hundred case vignettes that explore the universe of epilepsy as it presents in daily practice. Some of these cases challenge long-held views about epilepsy and others bring the reader to the limits of our understanding of epilepsy, both in clinical and basic science. To improve the interface of clinical and basic science in epilepsy, basic scientists comment on the potential mechanisms underlying clinical observations, and clinicians assess the po...
Orphans
The story begins before the turn of the century. The Gillis's live a very easy and tranquil life, in spite of active and noisy boys. But soon the tranquillity is shattered. First Albert then John die within months of each other. Then six years later Lydia and her husband Joseph die within months of each other. Lydia and Joseph leave six children and rather than have them stay with their grandmother Gillis, Joseph sends them to his sister in Sault Ste Marie, Ontario, Canada, just before he dies. Before long the uncle decides he wants their inheritance so he moves them to Kit Carson, Colorado. After all the hardships they have already encountered he puts them up in a tent on the prairie. Soon ...
