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Proceedings of the Fourth Seattle Symposium in Biostatistics: Clinical Trials
This volume contains a selection of chapters base on papers presented at the Fourth Seattle Symposium in Biostatistics: Clinical Trials. The symposium was held in 2010 to celebrate the 40th anniversary of the University of Washington School of Public Health and Community Medicine. It featured keynote lectures by David DeMets and Susan Ellenberg and 16 invited presentations by other prominent researchers. The papers contained in this volume encompass recent methodological advances in several important clinical trials research, such as biomarkers, meta-analyses, sequential and adaptive clinical trials, and various genetic bioinformatic techniques. This volume will be a valuable reference for researchers and practitioners in the field of clinical trials.
Data Monitoring Committees in Clinical Trials
The authoritative guide for Data Monitoring Committees—fully revised and updated The number of clinical trials sponsored by government agencies and pharmaceutical companies has grown in recent years, prompting an increased need for interim monitoring of data on safety and efficacy. Data Monitoring Committees (DMCs) are an essential component of many clinical trials, safeguarding trial participants and protecting the credibility and validity of the study. Data Monitoring Committees in Clinical Trials: A Practical Perspective, 2nd Edition offers practical advice for those managing and conducting clinical trials and serving on Data Monitoring Committees, providing a practical overview of th...
Montenegro
Portrays the history of Montenegro from the Middle Ages to the present. Predominantly Serbian since the ninth century, Montenegrins adopted clan organization for survival which fostered local loyalties but did not unify them against outside aggressors.
Counting Processes and Survival Analysis
The Wiley-Interscience Paperback Series consists of selected books that have been made more accessible to consumers in an effort to increase global appeal and general circulation. With these new unabridged softcover volumes, Wiley hopes to extend the lives of these works by making them available to future generations of statisticians, mathematicians, and scientists. "The book is a valuable completion of the literature in this field. It is written in an ambitious mathematical style and can be recommended to statisticians as well as biostatisticians." -Biometrische Zeitschrift "Not many books manage to combine convincingly topics from probability theory over mathematical statistics to applied ...
Data Monitoring Committees in Clinical Trials
The authoritative guide for Data Monitoring Committees—fully revised and updated The number of clinical trials sponsored by government agencies and pharmaceutical companies has grown in recent years, prompting an increased need for interim monitoring of data on safety and efficacy. Data Monitoring Committees (DMCs) are an essential component of many clinical trials, safeguarding trial participants and protecting the credibility and validity of the study. Data Monitoring Committees in Clinical Trials: A Practical Perspective, 2nd Edition offers practical advice for those managing and conducting clinical trials and serving on Data Monitoring Committees, providing a practical overview of the ...
Evolution of Translational Omics
Technologies collectively called omics enable simultaneous measurement of an enormous number of biomolecules; for example, genomics investigates thousands of DNA sequences, and proteomics examines large numbers of proteins. Scientists are using these technologies to develop innovative tests to detect disease and to predict a patient's likelihood of responding to specific drugs. Following a recent case involving premature use of omics-based tests in cancer clinical trials at Duke University, the NCI requested that the IOM establish a committee to recommend ways to strengthen omics-based test development and evaluation. This report identifies best practices to enhance development, evaluation, and translation of omics-based tests while simultaneously reinforcing steps to ensure that these tests are appropriately assessed for scientific validity before they are used to guide patient treatment in clinical trials.
Socialism
"Discusses socialism as a political system, and details the history of socialist governments throughout the world"--Provided by publisher.
Perspectives on Biomarker and Surrogate Endpoint Evaluation
In 2010 the Institute of Medicine (IOM) recommended a framework for the evaluation of biomarkers in the chronic disease setting. Published in the book Evaluation of Biomarkers and Surrogate Endpoints in Chronic Disease, the framework is intended to bring consistency and transparency to the previously disparate process of biomarker evaluation. Following the book's release, the IOM convened a 2-day discussion forum in Washington, DC, in order to provide an opportunity for stakeholders to learn about, react to, and discuss the book. Presentations reviewed the authoring committee's work process, recommendations, and provided perspectives on the book from the point of view of participants. Thomas...
Taxi to Tashkent
This is a police state This is a democracy This is rot-gut vodka This is $2 prostitutes This is Peace Corps This is good intentions This is Ramadan This is loyalty This is power outages This is corruption This is the Silk Route This is the former USSR This is Uzbekistan Tom Fleming went to Uzbekistan as a forty year old Peace Corps volunteer. He was a fish out of water, an infidel in a Muslim land, teaching AIDS prevention and sex education in the most conservative region of Central Asia. With humor and poignancy "Taxi to Tashkent" portrays a land little known in the West. Instead of a nation rife with Islamic extremists as portrayed in the Western media, Fleming discovers a land of Korean discos, where blue eyed Muslims listen to Shania Twain, and where shop owners break into applause at the mention of America. Fleming travels throughout Uzbekistan, from the ecological disaster site of the Aral Sea, to the ancient Silk Route cities of Bukhara and Samarkand. "Taxi to Tashkent" describes a little-known corner of the world where nothing appears as it seems.
A Disease in the Public Mind
By the time John Brown hung from the gallows for his crimes at Harper's Ferry, Northern abolitionists had made him a “holy martyr” in their campaign against Southern slave owners. This Northern hatred for Southerners long predated their objections to slavery. They were convinced that New England, whose spokesmen had begun the American Revolution, should have been the leader of the new nation. Instead, they had been displaced by Southern “slavocrats” like Thomas Jefferson. This malevolent envy exacerbated the South's greatest fear: a race war. Jefferson's cry, “We are truly to be pitied,” summed up their dread. For decades, extremists in both regions flung insults and threats, creating intractable enmities. By 1861, only a civil war that would kill a million men could save the Union.
