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Progressive Neuroblastoma
Neuroblastoma is a tumor derived from the sympathetic nervous system. It is the most common extracranial solid tumor occurring in children and exhibits a marked variability in outcome when the disease is categorized by clinical (e.g. age or stage) and biologic characteristics. This book gives an introduction into the clinical features of progressive neuroblastoma and focuses on molecular-targeted therapies and immunotherapies of this disease. It has become increasingly clear that MYCN (v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog) holds a key position in neuroblastic transformation and gene expression in normal and transformed cells. In the 14 chapters important ...
Neuroblastoma
Neuroblastoma is a medical enigma. As a childhood neoplasm arising from neural crest cells, it is characterized by diverse clinical behaviors ranging from spontaneous remission to rapid tumor progression and death. Although clinical outcome can be predicted to a large extent by the stage of disease and the age at diagnosis, an in-depth understanding of its clinico-pathological behavior, now greatly aided by sophisticated molecular genetic profiling, will improve diagnostic precision and refine risk-based therapies. Comprehensive international efforts have advanced our understanding of tumor biology and improved the clinical management of children with neuroblastoma. This book reviews our current understanding of the genes and biological pathways that contribute to neuroblastoma pathogenesis, modern risk-based treatment approaches for these patients, and recent advances in biologically based therapy. It provides a concise up-to-date reference for practitioners, students, and researchers.
Censorship and Exile
Dieser Band behandelt aus interdisziplinärer und transnationaler Perspektive die Zusammenhänge zwischen Exilerfahrung und Zensurmechanismen. Er versammelt literatur- und sprachwissenschaftliche Beiträge, die den Themenkomplex aus komparativer, historischer, politischer und kreativer Perspektive beleuchten. Dabei werden die Kontinuitäten und Diskontinuitäten der Exilliteraturforschung, der Entstehung verschiedener Formen von Exilliteratur und Zensurpraktiken als institutionalisierte Form der Unterdrückung freier Meinungsäußerung und künstlerischer Freiheit in Beziehung zueinander gesetzt. Der Band stellt somit einen in bedeutenden Beitrag zur theoretisch wie auch anwendungsbezogenen Zensur- und Exilforschung dar.
Coworking Atmospheres
The study by Alexandra Bernhardt deals with coworking spaces and their atmospheres. In addition to a comprehensive consideration of the role of atmospheres, the special significance of community in the context of these work spaces is examined in more detail. Two case studies in urban coworking spaces form the core of the investigation, following a qualitative research design oriented towards ethnography and a plurality of methods. In the context of the analysis, on the one hand, what constitutes coworking in everyday life and thus the new communality at work is considered: relevant practices and rituals, spatial arrangements and atmospheres are elaborated in their composition. On the other h...
Foundations of Software Science and Computation Structures
This open access book constitutes the proceedings of the 24th International Conference on Foundations of Software Science and Computational Structures, FOSSACS 2021, which was held during March 27 until April 1, 2021, as part of the European Joint Conferences on Theory and Practice of Software, ETAPS 2021. The conference was planned to take place in Luxembourg and changed to an online format due to the COVID-19 pandemic. The 28 regular papers presented in this volume were carefully reviewed and selected from 88 submissions. They deal with research on theories and methods to support the analysis, integration, synthesis, transformation, and verification of programs and software systems.
The Widows
Two bodies are discovered in a Stockholm park, one a policeman and the other an unidentified young woman.
der selfpublisher 9, 1-2018, Heft 9, März 2018
"der selfpublisher" – Deutschlands 1. Selfpublishing-Magazin Selfpublisher sind immer auf der Suche. Nach neuen Lesern. Nach Infos, wie sie ihre Bücher noch attraktiver machen. Und nach Dienstleistern, die ihnen helfen, diese Ziele erfolgreich umzusetzen. Mit dem neuen Magazin "der selfpublisher" bringen wir zusammen, was zusammengehört: Selfpublisher und Dienstleister. Interviews, Analysen und Umfragen dienen der Orientierung. Gestaltete Anzeigen und Textanzeigen bieten Dienstleistern die Chance, sich fachgerecht und zielgenau zu präsentieren. 2018 erscheint "der selfpublisher" im 3. Jahrgang; Auflage dieser Ausgabe: 8.000 Exemplare. Erscheinungstermine: "der selfpublisher" erscheint a...
