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Progressive Neuroblastoma
Neuroblastoma is a tumor derived from the sympathetic nervous system. It is the most common extracranial solid tumor occurring in children and exhibits a marked variability in outcome when the disease is categorized by clinical (e.g. age or stage) and biologic characteristics. This book gives an introduction into the clinical features of progressive neuroblastoma and focuses on molecular-targeted therapies and immunotherapies of this disease. It has become increasingly clear that MYCN (v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog) holds a key position in neuroblastic transformation and gene expression in normal and transformed cells. In the 14 chapters important ...
Catherine Cheskinova
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Censorship and Exile
Dieser Band behandelt aus interdisziplinärer und transnationaler Perspektive die Zusammenhänge zwischen Exilerfahrung und Zensurmechanismen. Er versammelt literatur- und sprachwissenschaftliche Beiträge, die den Themenkomplex aus komparativer, historischer, politischer und kreativer Perspektive beleuchten. Dabei werden die Kontinuitäten und Diskontinuitäten der Exilliteraturforschung, der Entstehung verschiedener Formen von Exilliteratur und Zensurpraktiken als institutionalisierte Form der Unterdrückung freier Meinungsäußerung und künstlerischer Freiheit in Beziehung zueinander gesetzt. Der Band stellt somit einen in bedeutenden Beitrag zur theoretisch wie auch anwendungsbezogenen Zensur- und Exilforschung dar.
Neuroblastoma
Neuroblastoma is a medical enigma. As a childhood neoplasm arising from neural crest cells, it is characterized by diverse clinical behaviors ranging from spontaneous remission to rapid tumor progression and death. Although clinical outcome can be predicted to a large extent by the stage of disease and the age at diagnosis, an in-depth understanding of its clinico-pathological behavior, now greatly aided by sophisticated molecular genetic profiling, will improve diagnostic precision and refine risk-based therapies. Comprehensive international efforts have advanced our understanding of tumor biology and improved the clinical management of children with neuroblastoma. This book reviews our current understanding of the genes and biological pathways that contribute to neuroblastoma pathogenesis, modern risk-based treatment approaches for these patients, and recent advances in biologically based therapy. It provides a concise up-to-date reference for practitioners, students, and researchers.
Coworking Atmospheres
The study by Alexandra Bernhardt deals with coworking spaces and their atmospheres. In addition to a comprehensive consideration of the role of atmospheres, the special significance of community in the context of these work spaces is examined in more detail. Two case studies in urban coworking spaces form the core of the investigation, following a qualitative research design oriented towards ethnography and a plurality of methods. In the context of the analysis, on the one hand, what constitutes coworking in everyday life and thus the new communality at work is considered: relevant practices and rituals, spatial arrangements and atmospheres are elaborated in their composition. On the other h...
