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Natural Products and Human Diseases
Natural products have a long history of use as folk medicines in several systems of traditional medicine. Extensive evidence from modern pharmacological studies has confirmed traditional applications, and unveiled the vast potential of naturally occurring compounds, particularly plant-derived phytochemicals, in the management of chronic human diseases. The past decade has witnessed a surge of findings from randomized controlled trials testifying the safety and efficacy of natural products as adjuncts or alternatives to standard-of-care medications for several illnesses. Biomolecular studies have unveiled hundreds of cellular and molecular targets for phytochemicals including key transcriptio...
Clinical, Biological and Molecular Aspects of COVID-19
The novel coronavirus 2019 (COVID-19) has caused a serious global pandemic in just eight months. Nearly every country and territory in the world has been affected by the virus. The virulence and infection rate of the virus are profound, and has required extreme social distancing measures across the globe in order to prevent overwhelming the healthcare services and hospitals. COVID-19 appears to have the greatest effects on elderly individuals and those who have co-morbid diseases, such as heart disease, asthma, and diabetes. As the peak begins to slow in many countries, the death rates remain high amidst justified fears of a second wave. A rapid worldwide mobilization has begun to identify e...
Proceedings of the 3rd International Conference on Agriculture (ICA 2022)
This is an open access book. The global economy is by definition the movement of resources (goods, services and capital) across national borders. The more open relations between countries will affect changes in the regional and global regions, this condition is characterized by the level of domestic economic resilience. Currently, technology with its dynamics requires every country to move to follow, citing at the G20 the role of multilateral trading system to strengthen the achievement SDGs, digital trade sustainable, global value chains (GVCs) and sustainable and inclusive industrialization via industry 4.0. Based on the statement above, it shows that modernization and sustainable 4.0 equi...
Cardiovascular Complications of COVID-19
This book is the first comprehensive approach on COVID-19 cardiac complications, both during the acute phase as well as in the long-COVID period. It provides an up-to-date and highly illustrated summary of the biology of SARS-CoV-2, the course of COVID-19, risk factors that worsen the disease in COVID-19 patients, clinical features of COVID-19 patients, COVID-19 cardiological complications, treatment, and prevention methods, and long-term cardiological aspects of COVID-19. Chapters provide the reader with a contemporary perspective on the emerging links between COVID-19 and cardiovascular disease. In addition, this volume discusses the clinical implications and therapeutic goals in patients ...
Practical Guide to Visualizing Medicine
This book provides a practically orientated resource that details the use a range of imaging techniques across major specialties plus those that are less well represented in standard textbooks (e.g. cardiothoracic surgery, palliative care, geriatric medicine, skin conditions from diverse ethnic groups). Emphasis is placed on enabling the reader to interpret images and clinical data, while avoiding mistakes and pitfalls in their day-to-day practice. Detailed question and answer sections along with insightful videos reinforce key messages (e.g. visualizing heart murmurs). Grading of questions aids navigation, with more difficult questions to benefit the high-flying students/junior doctors prep...
Testosterone
An Independent Publisher Book Awards Gold Medal Winner A Progressive Book of the Year A TechCrunch Favorite Read of the Year “Deeply researched and thoughtful.” —Nature “An extended exercise in myth busting.” —Outside “A critique of both popular and scientific understandings of the hormone, and how they have been used to explain, or even defend, inequalities of power.” —The Observer Testosterone is a familiar villain, a ready culprit for everything from stock market crashes to the overrepresentation of men in prisons. But your testosterone level doesn’t actually predict your appetite for risk, sex drive, or athletic prowess. It isn’t the biological essence of manliness...
Vitamin D Binding Protein, Total and Free Vitamin D Levels in Different Physiological and Pathophysiological Conditions
There is a high prevalence of vitamin D deficiency worldwide, but how to define vitamin D deficiency is controversial. Currently, the plasma concentration of total 25-hydroxyvitamin D [25(OH)D] is considered an indicator of vitamin D status. The free hormone hypothesis states that protein-bound hormones are inactive while unbound hormones are free to influence biological activity. The majority of circulating 25(OH)D and 1,25(OH)2D is tightly bound to vitamin D binding protein (DBP), 10 -15% is bound to albumin, and less than 1% of circulating vitamin D exists in an unbound form. While DBP is relatively stable in most healthy populations, recent studies have shown that there are gene polymorphisms associated with race and ethnicity that could alter DBP levels and binding affinity. Furthermore, in some clinical situations total 25(OH)D levels are altered, and knowing whether DBP is also altered may have implications for diagnosis and treatment. In this Research Topic, we provide a collection of comprehensive research on vitamin D and DBP metabolism among different ethnic population and patients with different diseases.
Application of Omic Techniques to Identify New Biomarkers and Drug Targets for COVID-19
The COVID-19 pandemic caused by the SARS-CoV-2 virus has affected nearly every country and territory in the world. Although worldwide vaccination efforts have reduced the risk of serious disease outcomes, disparities in distribution have led to multiple waves of SARS-CoV-2 outbreaks and the emergence of variants of concern, some of which have enhanced infectivity and ability to evade existing vaccines. Hence there is an increasing interest in understanding the evolution of viruses like SARS-CoV-2, as well as improving our capacity to effectively current and manage future pandemics. This new volume reviews the most effective omic techniques for increasing our understanding of COVID-19, to imp...
Pharmacological Properties of Plant-Derived Natural Products and Implications for Human Health
Medicinal plants and their derived products remain as an indispensable source of bioactive molecules that serve as either drug candidates or lead compounds for drug design and discovery. There are several advantages for plant-derived therapeutics including wide availability, diverse pharmacological actions and a generally good profile of safety and tolerability. Over the recent years, there have been numerous reports from clinical studies testifying to the efficacy and safety of medicinal plants and phytochemicals in ameliorating several human diseases. A plethora of basic studies has also unravelled molecular mechanisms underlying the health benefits of herbal medicines. Nevertheless, issues such as identification of bioactive ingredients, standardization of the products and drug interactions remain to be further studied. In this book, we aim to put together several chapters on the medicinal properties and pharmacological action of medicinal plants, plant species and phytochemicals. The goal is to present a comprehensive collection on most of the therapeutic aspects of plant-derived natural products and molecular mechanisms thereof.
