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Autoimmune Diseases of the Skin
Autoimmune disorders of the skin remain an enigma for many clinicians and scientists not familiar with these mostly severe and chronic diseases. The book provides an overview and the latest information on the broad spectrum of cutaneous autoimmune disorders for clinicians, scientists and practitioners in dermatology, medicine, rheumatology, ENT, pediatrics and ophthalmology. The book is unique since it presents the state-of-the-art knowledge on pathophysiology, clinical diagnosis and management of these disorders provided by the world experts in the field. The primary intention is to broaden the understanding of the pathophysiology of cutaneous autoimmune disorders and to provide a practical guide to how to identify and handle these conditions. The book is illustrated with many tables, illustrative figures and clinical color photographs. The second edition has been extended by chapters on autoimmune pigmentary disorders (vitiligo), hairloss (alopecia areata) and cutaneous symptoms of rheumatic disorders.
Deciphering new molecular mechanisms of mast cell activation
Mast cells are tissue-localized cells that play an important role in immunity and inflammation. Following an offensive event they act as cellular sensors that via the activation of cell surface receptors launch a cellular response culminating in the release of a whole set of inflammatory mediators and products. This response is initially destined to restore tissue homeostasis, but in case of chronic injury or deregulation also promotes pathology. To further understand the action of mast cells in their environmental context it is necessary to decipher the molecular mechanisms of their activation as well as the ensuing cellular responses. This will allow identification of new strategies to pro...
Innate Immune Cell Determinants of T Cell Immunity: From Basic Mechanisms to Clinical Implications
Long-lasting T cell immunity is delivered by an array of individual T lymphocytes expressing clonally distributed and highly specific antigen receptors recognizing an almost infinite number of antigens that might enter in contact with the host. Following antigen-specific priming in lymphnodes, naïve CD4 and CD8 T lymphocytes proliferate generating clones of effector cells that migrate to peripheral tissues and deliver unique antigen-specific effector functions. Moreover, a proportion of these effector lymphocytes survive as memory T cells that can be rapidly mobilized upon new exposure to the same antigen, even years after their primary induction. Innate immune cells play crucial roles in t...
In Vitro Diagnosis of Allergic and Mast Cell-Related Disorders
Allergic diseases, affecting one in four people, are diagnosed through the demonstration of an abnormal immune response (sensitization) to a trigger (allergen) inducing a clinical hypersensitivity response. Allergen-induced immune responses can be demonstrated using in vivo (skin and challenge), or in vitro tests. The occurrence and severity of hypersensitivity reactions are influenced by mast cell disorders, such as hereditary alpha-tryptasemia, which is found in up to 8% of general population by means of serum tryptase measurement. The place of in vitro tests has considerably expanded since the beginning of the century, thanks to progress in multiple fields including allergen biochemistry,...
Allergic Diseases – From Basic Mechanisms to Comprehensive Management and Prevention
Allergy is the most frequent chronic disease in the 21st century having severe negative effects on health and the economy. The challenge we therefore face in medicine and science incorporates all areas of society – from politics to food industry, from schools to city planning, and many more. This volume informs the reader about continuously ongoing developments in allergy research and their implications for society. The chapter sections cover the immunological mechanisms in allergy on a molecular level, describe the triggers and cures for allergy in detail, entail clinical translation of lab findings on allergens, evaluate diagnostics for allergy markers, and provide solutions for future medical intervention or preventive strategies. Laboratory research, bioinformatics, climate modelling, patient treatment, intervention studies, epigenetics and multiple other disciplines are able to shed new light on this revolutionary field of healthcare.
Progress and Prospects on Skin Imaging Technology, Teledermatology and Artificial Intelligence in Dermatology
Topic Editor H. Peter Soyer is a shareholder of MoleMap NZ Limited and e-derm consult GmbH, and undertakes regular teledermatological reporting for both companies. He is a Medical Consultant for Canfield Scientific Inc., MetaOptima and Revenio Research Oy and also a Medical Advisor for First Derm.
Allergologie
Lehrbuch und Nachschlagewerk für eine praxisnahe und moderne Allergiediagnostik, -therapie und -prävention. Umfangreiche Darstellung der Klinik und der Diagnostik mit allen Haut- und Provokationstests, der In-vitro-Serumdiagnostik und der zellulären Diagnostik. Der Weg zu einer erfolgreichen Therapie wird mit allen modernen Methoden gezeigt und die Möglichkeiten der Prävention u.a. anhand von Patientenschulungen erläutert. Die neuesten Forschungsergebnisse finden sich in Grundlagenkapiteln zu Immunologie und Allergenen wieder. Alle klinischen Bilder aus Dermatologie, Pneumologie, Pädiatrie, HNO- und Augenheilkunde, Gastroenterologie sowie aus anderen wichtigen Bereichen, wie der Psychosomatik und Berufsallergologie, werden dargestellt. Die vollständig aktualisierte 2. Auflage ist ideal für Allergologen in Klinik und Niederlassung und hervorragend geeignet für die Ausbildung.
Häufige Hauttumoren in der Praxis
Hauttumoren – Übersichtliche Infos für die tägliche Praxis und das Hautkrebsscreening Warzen, Nävi, Zysten, Aktinische Keratosen, Malignes Melanom – in der täglichen Praxis begegnet der Arzt einer Vielzahl von Hauttumoren und tumorartigen Hautveränderungen. Die exakte Diagnose, die Einleitung einer passgenauen Therapie oder auch die Beruhigung eines Patienten mit einem harmlosen Befund setzten eine genaue Kenntnis der häufigsten Hauttumoren voraus. Bei malignen Erkrankungen erhöht eine frühzeitige exakte Diagnose die Chancen auf eine erfolgreiche Heilung. In der zweiten Auflage wurden alle Kapitel unter Berücksichtigung bestehender Leitlinien überarbeitet und mit neuen, aussag...
