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Exploring Protein Structure: Principles and Practice
This textbook introduces the basics of protein structure and logically explains how to use online software to explore the information in protein structure databases. Readers will find easily understandable, step-by step exercises and video-trainings to support them in grasping the fundamental concepts. After reading this book, readers will have the skills required to independently explore and analyze macromolecular structures, will be versed in extracting information from protein databases and will be able to visualize protein structures using specialized software and on-line algorithms. This book is written for advanced undergraduates and PhD students wishing to use information from structural biology in their assignments and research and will be a valuable source of information for all those interested in applied and theoretical aspects of structural biology.
Writing Scientific English
Success in science depends nowadays on effective communication in English. This workbook is specifically designed to give under- and post-graduates confidence in writing scientific English. Examples and exercises show how to avoid common errors and how to rephrase and improve scientific texts. The generation of a model manuscript enables the reader to recognise how scientific English is constructed and how to follow the conventions of scientific writing. Guidelines for structuring written work and vocabulary lists will encourage young scientists to develop a concise and mature style. The workbook is accessible to students of many fields, including those of the natural and technical sciences, medicine, psychology and economics.
Handbook of Proteolytic Enzymes
Extensively revised and updated, the new edition of the highly regarded Handbook of Proteolytic Enzymes is an essential reference for biochemists, biotechnologists and molecular biologists. Edited by world-renowned experts in the field, this comprehensive work provides detailed information on all known proteolytic enzymes to date. This two-volume set unveils new developments on proteolytic enzymes which are being investigatedin pharmaceutical research for such diseases as HIV, Hepatitis C, and the common cold. Volume I covers aspartic and metallo petidases while Volume II examines peptidases of cysteine, serine, threonine and unknown catalytic type. A CD-ROM accompanies the book containing f...
The Picornaviruses
A springboard for developing new approaches to understanding, preventing, and treating picornaviral diseases. • Examines the most current breakthroughs as well as the challenges that lie ahead in picornavirus research; encapsulates current knowledge of the molecular biology, evolution, and pathogenesis of this large family of viruses; and, examines the diseases that these viruses cause and the latest vaccines and antiviral drugs to prevent and control those diseases. • Explores the structural and mechanistic bases of picornavirus replication, highlighting new insights about the host cell interactions needed for virus growth; and, illustrates how the regular occurrence of mutations, typical of viruses with RNA as genetic material, generates the quasispecies dynamics that underlie viral fitness. • Focuses on picornaviruses that cause disease, examining pathogenicity and innate and acquired immune responses against infection as well as the latest vaccine and antiviral drug strategies.
Any Questions?
This book explores how academics at conferences co-construct their own and each other’s professional identities. It is based on the detailed sequential analysis of audio recordings of conference discussions in the field of the humanities, the working languages being French and English. The analyses show that the delegates who actively participate in these interactions, whether as presenters, chairpersons or as members of the audience, carry out a considerable amount of identity work, attributing self and other to various categories of professional identity. The discussion participants co-construct themselves and each other discursively as academics, professionals, experts, junior or senior members of the scientific community; they also orient to this identity work as an important task to be achieved at conferences. This study provides detailed insights into the fine-grained mechanics of spoken academic discourse. From the perspective of applied research it serves the double purpose of raising experienced researchers’ awareness of their own routines and introducing novices to the discourse practices of academia.
The Power of Prions
The remarkable family of proteins that can make us very ill—but can also be linked to long-term memory, immunity, and the origin of life Over the last decade, scientists have discovered the importance and widespread presence in the body of a remarkable family of proteins known as prion proteins. Research links various types of prion proteins to neurodegenerative diseases such as Parkinson’s and Alzheimer’s—and this has fueled the search for new drugs that could halt the progression of these terrible disorders. Other discoveries have revealed the essential roles prion proteins play in memory and immunity, and—in an extraordinary finding—the part they may have played in the beginni...
Handbook of Proteolytic Enzymes, Volume 1
Handbook of Proteolytic Enzymes, Second Edition, Volume 1: Aspartic and Metallo Peptidases is a compilation of numerous progressive research studies on proteolytic enzymes. This edition is organized into two main sections encompassing 328 chapters. This handbook is organized around a system for the classification of peptidases, which is a hierarchical one built on the concepts of catalytic type, clan, family and peptidase. The concept of catalytic type of a peptidase depends upon the chemical nature of the groups responsible for catalysis. The recognized catalytic types are aspartic, cysteine, metallo, serine, threonine, and the unclassified enzymes, while clans and families are groups of homologous peptidases. Homology at the level of a family of peptidases is shown by statistically significant relationship in amino acid sequence to a representative member called the type example, or to another member of the family that has already been shown to be related to the type example. Each chapter discusses the history, activity, specificity, structural chemistry, preparation, and biological aspects of the enzyme. This book will prove useful to enzyme chemists and researchers.
Exploring the Role of Antiviral Drugs in the Eradication of Polio
Exploring the Role of Antiviral Drugs in the Eradication of Polio: Workshop Report, is a report of a workshop in which experts evaluated whether an antiviral drug against poliovirus would be helpful in the final stages of the global polio eradication campaign. The World Health Organization currently plans to stop using oral polio vaccine three years after the detection of the last case of transmission of wild polio virus. This is because the vaccine contains live, weakened polio viruses that can spread and revert to virulence in populations that have not been immunized. Under this plan, an antiviral drug could be useful to control any polio outbreaks caused by a vaccine-derived virus that might occur after vaccination ends and the number of unimmunized people in the world steadily increases. The report recommends that planning and development of such drugs should be initiated now. It identifies several promising targets for drug development and outlines the steps needed for planning for clinical trials and regulatory approval.
The Viral Politics of Covid-19
This book critically examines the COVID-19 pandemic and its legal and biological governance using a multidisciplinary approach. The perspectives reflected in this volume investigate the imbrications between technosphere and biosphere at social, economic, and political levels. The biolegal dimensions of our evolving understanding of “home” are analysed as the common thread linking the problem of zoonotic diseases and planetary health with that of geopolitics, biosecurity, bioeconomics and biophilosophies of the plant-animal-human interface. In doing so, the contributions collectively highlight the complexities, challenges, and opportunities for humanity, opening new perspectives on how to inhabit our shared planet. This volume will broadly appeal to scholars and students in anthropology, cultural and media studies, history, philosophy, political science and public health, sociology and science and technology studies.
