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Targeting Ion Channels for Drug Discovery: Emerging Challenges for High Throughput Screening Technologies
Ligand and voltage-gated ion channels are highly regulated protein molecules that cross the cell membrane allowing ion flow from one side of the membrane to the other. They are ubiquitously expressed in human tissues and consist of one of the largest and best understood functional groups of proteins, with more than 400 members spanning nearly 1% of the human genome. They are involved in a variety of fundamental physiological processes, and their malfunction causes numerous diseases. In terms of the challenges faced in the effort to discover specific drugs in ancient and emerging diseases, ion channels are the third-largest class of target proteins after G-protein-coupled receptors (GPCRs) an...
On Beer and Brewing Techniques in Ancient Mesopotamia
This fascinating text deciphers the neo-Babylonian inscriptions on the 23rd Tablet, acquired by the Metropolitan Museum of Art in New York in 1886, which describes the preparation of alcoholic beverages from cereals in Mesopotamia. This classic work would make a wonderful addition to the library of anyone with an interest in the Mesopotamian period, lexicography, and the ancient history of beer brewing. Contents include: Beer Brewing; 1 - The New Text: Met. Mus. 86-11-386; 2 - The Technology of The Brewer; 3 - Contents of The Tablet; 4 - Transliteration and Translation; 5 - Apparatus Criticus; 6 - index of Discussed Words; 7 - List of Illustrations; Notes; Additions and Corrections. This vintage text is being republished in a high quality, modern and affordable edition. It comes complete with a new introduction and features reproductions of the original illustrations.
Babylonian Topographical Texts
Babylonian Topographical Texts collects for the first time all Babylonian and Assyrian texts of the first millennium B.C. that belong to what is designated the topographical genre. Much of the material is not previously published. The book is largely concerned with Babylon. Seventeen texts on this city now allow its topography to be properly understood for the first time. Another seventeen texts concern the cities of Nippur, Assur, Kish and Uruk. Also included are thirty miscellaneous texts, mostly new, which bear upon topographical matters. The text editions and translations are supplemented by a philological and topical commentary. The work is concluded with full indices, and 57 plates of cuneiform copies.
