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T cell specificity and Cross-reactivity – Implications in Physiology and Pathology
Conventional CD8+ and CD4+ T cells recognize antigens, presented by antigen-presenting cells in the form of short peptides loaded onto major histocompatibility complex (MHC) class I and class II molecules, through their T cell receptor (TCR). Somatic gene rearrangement of the TCR locus and randomization of TCR hyper-variable regions generate the marked diversity of TCRs. Once assembled, the heterodimeric TCR confers specificity to naïve T cells. The naïve T cell repertoire of an individual is established by selection processes in the thymus and cannot be broadened upon antigen recognition by additional somatic mutations. In humans, the estimated number of distinct TCRs in the naïve T cell...
Applications of Computational Intelligence in Biology
Computational Intelligence (CI) has been a tremendously active area of - search for the past decade or so. There are many successful applications of CI in many sub elds of biology, including bioinformatics, computational - nomics, protein structure prediction, or neuronal systems modeling and an- ysis. However, there still are many open problems in biology that are in d- perate need of advanced and e cient computational methodologies to deal with tremendous amounts of data that those problems are plagued by. - fortunately, biology researchers are very often unaware of the abundance of computational techniques that they could put to use to help them analyze and understand the data underlying ...
Parafia Kompina
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Controlled/living Radical Polymerization
Recent progress in the field of controlled/living radical polymerization.
The Jazz Discography
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Ruch teatralny
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Towards a Synergistic Combination of Research and Practice in Software Engineering
This book reports on recent advances in software engineering research and practice. Divided into 15 chapters, it addresses: languages and tools; development processes; modelling, simulation and verification; and education. In the first category, the book includes chapters on domain-specific languages, software complexity, testing and tools. In the second, it reports on test-driven development, processing of business rules, and software management. In turn, subsequent chapters address modelling, simulation and verification of real-time systems, mobile systems and computer networks, and a scrum-based framework. The book was written by researchers and practitioners, the goal being to achieve a synergistic combination of research results achieved in academia and best practices used in the industry, and to provide a valuable reference guide for both groups.
