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T cell specificity and Cross-reactivity – Implications in Physiology and Pathology
Conventional CD8+ and CD4+ T cells recognize antigens, presented by antigen-presenting cells in the form of short peptides loaded onto major histocompatibility complex (MHC) class I and class II molecules, through their T cell receptor (TCR). Somatic gene rearrangement of the TCR locus and randomization of TCR hyper-variable regions generate the marked diversity of TCRs. Once assembled, the heterodimeric TCR confers specificity to naïve T cells. The naïve T cell repertoire of an individual is established by selection processes in the thymus and cannot be broadened upon antigen recognition by additional somatic mutations. In humans, the estimated number of distinct TCRs in the naïve T cell...
The Rainbow Goblins
After seven goblins try to steal it, the Rainbow is careful never again to touch the earth.
The Jazz Discography
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Controlled/living Radical Polymerization
Recent progress in the field of controlled/living radical polymerization.
Ruch teatralny
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Towards a Synergistic Combination of Research and Practice in Software Engineering
This book reports on recent advances in software engineering research and practice. Divided into 15 chapters, it addresses: languages and tools; development processes; modelling, simulation and verification; and education. In the first category, the book includes chapters on domain-specific languages, software complexity, testing and tools. In the second, it reports on test-driven development, processing of business rules, and software management. In turn, subsequent chapters address modelling, simulation and verification of real-time systems, mobile systems and computer networks, and a scrum-based framework. The book was written by researchers and practitioners, the goal being to achieve a synergistic combination of research results achieved in academia and best practices used in the industry, and to provide a valuable reference guide for both groups.
Marine Navigation and Safety of Sea Transportation
In recent years much attention has been paid to safety of navigation and marine transportation. Marine Navigation and Safety of Sea Transportation addresses the main aspects of marine safety, including: safety of navigation; manoeuvering and ship-handling systems; marine traffic control and automatic identification systems; navigation tools, system
Dissident Legacies of Samizdat Social Media Activism
This book tells the story of the dissident imaginary of samizdat activists, the political culture they created, and the pivotal role that culture had in sustaining the resilience of the oppositional movement in Poland between 1976 and 1990. This unlicensed print culture has been seen as one of the most emblematic social worlds of dissent. Since the Cold War, the audacity of harnessing obsolete print technology known as samizdat to break the modern monopoly of information of the party-state has fascinated many, yet this book looks beyond the Cold War frame to reappraise its historical novelty and significance. What made that culture resilient and rewarding, this book argues, was the correspon...
