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Spacecraft Water Exposure Guidelines for Selected Contaminants
The International Space Station is a closed and complex environment, so some contamination of its internal atmosphere and water system is expected. To protect space crews from contaminants in potable and hygiene water, the National Aeronautics and Space Administration (NASA) requested that the National Research Council (NRC) provide guidance on how to develop water exposure guidelines and review NASA's development of the exposure guidelines for specific chemicals. NASA selects water contaminants for which spacecraft water exposure guidelines (SWEGs) will be established; this involves identifying toxicity effects relevant to astronauts and calculating exposure concentrations on the basis of t...
Spacecraft Maximum Allowable Concentrations for Selected Airborne Contaminants
NASA is aware of the potential toxicologic hazards to crew that might be associated with prolonged spacecraft missions. Despite major engineering advances in controlling the atmosphere within spacecraft, some contamination of the air appears inevitable. NASA has measured numerous airborne contaminants during space missions. As the missions increase in duration and complexity, ensuring the health and well-being of astronauts traveling and working in this unique environment becomes increasingly difficult. As part of its efforts to promote safe conditions aboard spacecraft, NASA requested the National Research Council to develop guidelines for establishing spacecraft maximum allowable concentra...
Essays in Toxicology
Essays in Toxicology, Volume 5 covers essays in toxicology. The book presents essays on nitrosamines; a laboratory model ecosystem to evaluate compounds producing biological magnification; and the metabolism of DDT in human. The text also includes essays on the toxins of Clostridium botulinum; the use of breath analysis in clinical toxicology; and the biochemical toxicology of methanol. Toxicologists, biochemists, microbiologists, pharmacologists, and people involved in the research of toxicology will find the book invaluable.
Alcohol and Aldehyde Metabolizing Systems-IV
The papers in this book represent the proceedings of the Third International Symposium, which was held at the Addiction Research Foundation in Toronto in July, 1979. The purpose of this meeting was to bring together experts in the field from a wide variety of backgrounds in an attempt to gain some clarity and insight into the problems of alcohol and aldehyde metabolism. One might ask, "Why have such a meeting and a collection of research papers?" The answer is clear. The societal problem of alcoholism is, unlike many other health problems, growing instead of abating. Treatment efforts are largely ineffective (e.g., Griffith Edwards' classic work)', and fundamental research has yet to identif...
Biological Reactive Intermediates III
This volume contains the proceedings of the third in a series of conferences entitled, The International Symposium on Biological Reactive Intermediates. The first was held at the University of Turku in Finland, in 1975, the second at the University of Surrey in the United Kingdom, in 1980 and the most recent at the University of Maryland in the United States, in 1985. The significance of these conferences has been emphasized by the rapid growth of mechanistic toxicology over the last decade. These conferences were initially stimulated by the attempt to uncover the significance behind the observations that the toxicity of carcinogenic responses produced by many chemicals was associated with t...
Annual Reports in Medicinal Chemistry
Annual Reports in Medicinal Chemistry
Toxic Substances and Human Risk
As society has become increasingly aware of the potential threats to human health due to exposures to toxic chemicals in the environment and the workplace and in consumer products, it has placed increased demands upon the still-fledgling science of toxicology. As is often the case when science is called upon to supply firm answers when pertinent information and fundamental knowledge are lack ing, both the scientific and the social issues become confused and new tensions develop. One of the major purposes of this book is to focus on those aspects of the science of toxicology that pertain most to social issues-namely, analysis of risk for purposes of human health protection. Although it is app...
Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques
Fourteen years have elapsed since the appearance of the first volume and it is with great pleasure that the Editor is now able to present volume 17. During these fourteen years various fields of drug research have undergone important, partly revolutionary, changes. A number of these have already been dealt with, so that the series PROGRESS IN DRUG RESEARCH contains a comprehensive review of a substantial part of our current knowledge. The Editor is particularly grateful for the opportunity of transmitting to those connected with the devel opment of drugs the extensive knowledge of the Authors, who, without exception, are themselves actively engaged in research. Drug research is currently in a state of transformation: reconsideration in the light of the past and reorientation with a view to the future. To a large extent this is due to the tumultuous developments in the last 20 years, developments which are unparalleled in the history of medicine and the consequences of which cannot yet be completely evaluated. Unfortunately, however, the current situation is not devoid of its unpleasant and even tragic aspects, aspects which fall outside the research worker's sphere or influence.
Toxicology, An Issue of Critical Care Clinics
Topics include: Cocaine intoxication, Carbon monoxide poisoning, Update on miscellaneous drug overdoses, T oxidromes, Cardiac glycoside toxicity, Acetaminophen overdose, Envenomations, Methanol and ethylene glycol ingestion, and Toxicologic causes of ketoacidosis.
Nutritional Genomics
The definitive guide to the basic principles and latest advances in Nutritional Genomics Though still in its infancy, nutritional genomics, or "nutrigenomics," has revealed much about the complex interactions between diet and genes. But it is in its potential applications that nutrigenomics promises to revolutionize the ways we manage human health and combat disease in the years ahead. Great progress already has been made in modeling "personalized" nutrition for optimal health and longevity as well as in genotype-based dietary interventions for the prevention, mitigation, or possible cure of a variety of chronic diseases and some types of cancer. Topics covered include: * Nutrients and gene ...
