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Management of Periprosthetic Joint Infection
Periprosthetic joint infection (PJI) is among the most serious complications in the field of endoprosthetics. The number of PJIs is increasing worldwide and poses a real interdisciplinary challenge for everyone involved. For the patient concerned, it is necessary to promptly work out an adequate therapy solution to fight off the infection. Both the clinical experience of the surgeon and the proper diagnostic processes are prerequisite for the reliable detection and identification of an infection. The microbiologist is responsible for identifying the causative germs by screening the patient’s synovial fluid and tissue samples. Based on the findings and subsequent resistance testing, the inf...
Bacteriophage Therapy
This highly anticipated second edition details cutting-edge experimental approaches for bacteriophage research. This comprehensive volume details new and updated experimental approaches for isolating, formulating, and engineering bacteriophage medicinal products. Authored by leading experts and written in the highly successful Methods in Molecular Biology series format, each chapter includes introductions to their respective topics, lists of the necessary materials and reagents, step-by-step reproducible laboratory protocols, and valuable tips for troubleshooting and avoiding known pitfalls. Whether you are a seasoned scientist or a newcomer, Bacteriophage Therapy: From Lab to Clinical Practice, Second Edition provides essential tools and knowledge to advance bacteriophage research and its translation into innovative medicinal products and clinical therapies.
Staphylococci in Human Disease
Staphylococci remain the most important cause of hospital-acquiredinfections in the U.S. and MRSA has become the most common cause ofskin and soft tissue infection in many parts of the world. There is now a much greater understanding of the physiology andevolution of the staphylococci and this new edition reflects therapid advancements in knowledge about this pathogen and provides acomprehensive review from both clinical and basic scienceperspectives. The first section addresses the basic biology of thestaphylococci, their molecular genetics, host defenses and hostevasion, virulence determinants, mechanisms of antibioticresistance, and laboratory techniques. The second section dealswith epidemiology, and the third section provides an overview ofthe varied clinical manifestations of human staphylococcalinfections. The fourth section covers prevention and treatment ofthese often life-threatening infections. Written by experts from around the globe, this book is essentialreading for all clinicians and basic scientists studying thestaphylococci.
Infection in Knee Replacement
This book provides an in-depth overview of the aetiology, treatment and prevention of infections following knee arthroplasty. It presents up-to-date information on available techniques and salvage procedures for complex patients with infected, total knee arthroplasty. Divided into 5 sections, this book explores biomaterials, clinical manifestations, diagnosis, treatment and prevention, including preoperative optimisation, in order to reduce knee infections. This book is a valuable reference resource for practicing orthopaedic surgeons, residents, and medical students wishing to understand the fundamental concepts in infectious disease medicine needed in current orthopaedic practice.
The Good Virus: The Amazing Story and Forgotten Promise of the Phage
A New York Times Editors’ Choice “A deft narrative that is rich and approachable.” —Alex Johnson, New York Times Book Review How a mysterious, super-powerful—yet long-neglected—microbe rules our world and can rescue our health in the age of antibiotic resistance. At every moment, within our bodies and all around us, trillions of microscopic combatants are waging a war that shapes our health and life on Earth. Countless times per second, viruses known as phages attack and destroy bacteria while leaving all other life forms, including us, unscathed. Vastly outnumbering the viruses that do us harm, phages power ecosystems, drive evolutionary innovation, and harbor a remarkable capac...
A New Kind of Zeal 3: The Crux of Salvation
Two and a half years have passed since Kensington confronted his son Alex in Saint PeterÍs Cathedral, Wellington, New Zealand. Alex has been studying at Victoria University, while the Prime Minister James Connor continues to lead the nation from the Beehive. Rachel Connor has been training to become a Physician, while her husband, John Robertson, remains in the Cathedral with Bishop Mark Blake. Tristan Blake has been watching Alex. Tristan sees the legacy of AlexÍs past: a past Alex seems to be trying to hide. What might become of him? Rau Petera remains on the shores of Oriental Bay, offering good news: but Tristan is watching. The nation has suffered an upheaval, and has settled in a kind of peace _ but Tristan is uneasy. Trouble is brewing overseas; trouble within. Kensington is taking a greater hold. Powers are rising: the world is at risk of war. What fate will beset the nation? What forces, in the midst of the growing darkness, will win?
Emerging Concepts in Bacterial Biofilms
The ability to form biofilms is a universal attribute of bacteria. Bacteria are able to grow on almost every surface, forming these architecturally complex communities. In biofilms, the cells grow in multicellular aggregates, encased in an extracellular matrix produced by the bacteria themselves. They impact humans in many ways, and can form in natural, medical and industrial settings. For example, the formation of biofilms on medical devices such as catheters or implants often results in difficult-to-treat chronic infections. This book focuses on emerging concepts in bacterial biofilm research, such as the different mechanisms of biofilm formation in Gram negative and Gram positive bacteria, and the burden of biofilm associated infections. It also highlights the various anti-biofilm strategies that can be translated to curb biofilm-associated infections and the escalation of antimicrobial resistance determinants.
Tristan
A near-fatal plane crash has made a serious dent in the career (and body) of Lieutenant Tristan von Ohr. He is one of the German fl ying aces who took part in the brilliant air campaign of Bloody April, 1917. German aviation has revolutionized 20th century warfarethanks in part to Tristans friend Anthony Fokker. Transferred to the air service reserves, Tristan discovers that he is a poster boy in a glorious war that is doomed to failure. Americas entry into the Great War means that a whole generation of German youthincluding Tristans buddiesis being slaughtered for no purpose. The Fatherlands chances of victory are now zero. Every day the public is being told lies about the war aims, lies ab...
BMJ
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