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This practically oriented book provides an up-to-date overview of all significant aspects of the pathogenesis of sepsis and its management, including within the intensive care unit. Readers will find information on the involvement of the coagulation and endocrine systems during sepsis and on the use of biomarkers to diagnose sepsis and allow early intervention. International clinical practice guidelines for the management of sepsis are presented, and individual chapters focus on aspects such as fluid resuscitation, vasopressor therapy, response to multiorgan failure, antimicrobial therapy, and adjunctive immunotherapy. The closing section looks forward to the coming decade, discussing novel trial designs, sepsis in low- and middle-income countries, and emerging management approaches. The book is internatio nal in scope, with contributions from leading experts worldwide. It will be of value to residents and professionals/practitioners in the fields of infectious diseases and internal medicine, as well as to GPs and medical students.
Algebraic topology is a basic part of modern mathematics, and some knowledge of this area is indispensable for any advanced work relating to geometry, including topology itself, differential geometry, algebraic geometry, and Lie groups. This book provides a detailed treatment of algebraic topology both for teachers of the subject and for advanced graduate students in mathematics either specializing in this area or continuing on to other fields. J. Peter May's approach reflects the enormous internal developments within algebraic topology over the past several decades, most of which are largely unknown to mathematicians in other fields. But he also retains the classical presentations of various topics where appropriate. Most chapters end with problems that further explore and refine the concepts presented. The final four chapters provide sketches of substantial areas of algebraic topology that are normally omitted from introductory texts, and the book concludes with a list of suggested readings for those interested in delving further into the field.
The book represents a collection of papers presented at VI International Symposium "Biogenic - abiogenic interactions in natural and anthropogenic systems" that was held on 24-27 September 2018 in Saint Petersburg (Russia). Papers in this book cover a wide range of topics connecting with interactions between biogenic and abiogenic components in lithosphere, biosphere and technosphere. The main regarding topics are following: methods for studying the interactions between biogenic and abiogenic components; geochemistry of biogenic-abiogenic systems; biomineralization and nature-like materials and technologies; medical geology; biomineralogy and organic mineralogy; biomineral interactions in soil; biodeterioration of natural and artificial materials; biomineral interactions in extreme environment.
This book provides a comprehensive overview of the emerging technologies for next-generation 5G mobile communications, with insights into the long-term future of 5G. Written by international leading experts on the subject, this contributed volume covers a wide range of technologies, research results, and networking methods. Key enabling technologies for 5G systems include, but are not limited to, millimeter-wave communications, massive MIMO technology and non-orthogonal multiple access. 5G will herald an even greater rise in the prominence of mobile access based upon both human-centric and machine-centric networks. Compared with existing 4G communications systems, unprecedented numbers of sm...
Nonlinear Assignment Problems (NAPs) are natural extensions of the classic Linear Assignment Problem, and despite the efforts of many researchers over the past three decades, they still remain some of the hardest combinatorial optimization problems to solve exactly. The purpose of this book is to provide in a single volume, major algorithmic aspects and applications of NAPs as contributed by leading international experts. The chapters included in this book are concerned with major applications and the latest algorithmic solution approaches for NAPs. Approximation algorithms, polyhedral methods, semidefinite programming approaches and heuristic procedures for NAPs are included, while applications of this problem class in the areas of multiple-target tracking in the context of military surveillance systems, of experimental high energy physics, and of parallel processing are presented. Audience: Researchers and graduate students in the areas of combinatorial optimization, mathematical programming, operations research, physics, and computer science.
In the first edition of Genetics and Molecular Biology, renowned researcher and award-winning teacher Robert Schleif produced a unique and stimulating text that was a notable departure from the standard compendia of facts and observations. Schleif's strategy was to present the underlying fundamental concepts of molecular biology with clear explanations and critical analysis of well-chosen experiments. The result was a concise and practical approach that offered students a real understanding of the subject. This second edition retains that valuable approach--with material thoroughly updated to include an integrated treatment of prokaryotic and eukaryotic molecular biology. Genetics and Molecu...
"This book is intended to be an introductory text, not a comprehensive treatment of the Swedish vegetation. [The editors] hope that students, teachers, nature conservationists and ecologists will find it a useful introduction as well as a source book"--p. 4.
While there has been an increasing number of books on various aspects of epigenetics, there has been a gap over the years in books that provide a comprehensive understanding of the fundamentals of chromatin. Chromatin is the combination of DNA and proteins that make up the genetic material of chromosomes. Its primary function is to package DNA to fit into the cell, to strengthen the DNA to prevent damage, to allow mitosis and meiosis, and to control the expression of genes and DNA replication. The audience for this book is mainly newly established scientists and graduate students. Rather than going into the more specific areas of recent research on chromatin the chapters in this book give a strong, updated groundwork about the topic. Some the fundamentals that this book will cover include the structure of chromatin and biochemistry and the enzyme complexes that manage it.