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Highlights in Ubiquinone Research
The proceedings of the international symposium Biochemistry, Bioenergetics and Clinical Applications of Ubiquinone held in Bologna, Italy in May 1989. An important component of electron transport chains, ubiquinone has medical uses. A recipe for coenzyme Q Bolognese is included!
Coenzyme Q
It is becoming increasingly apparent that Coenzyme Q (Ubiquinone) is a major component of the electron transfer chains within aerobic micro-oganisms, photo-synthetic micro-organisms and mitochondria of eukaryotes. In particular, the proposal by Nobel laureate, Peter Mitchell, that Coenzyme Q possibly acts as a proton translocator within a proton motive Q-cycle, thus establishing an electrochemical membrane potential which in turn drives ATP synthesis, has received wide attention. This exhaustive, inter-disciplinary study discusses Ubiquinone's chemical and physical properties, metabolism, and function in different organisms.
Biomedical and Clinical Aspects of Coenzyme Q
During the last year or two, the scientific and medical interest in CoQ has remarkably increased to the extent that the increase might be said to be "explosive". CoQ 10 seems to be the first therapy that significantly improves the survival rate of patients as compared to those treated with conventional therapy. The book furthermore points out that cardiology should no longer be the first priority for clinical research in CoQ 10 , but immunology, although many aspects of CoQ 10 in cardiology remain for continuing research. Many interesting presentations and heated discussions on recent key issues are reflected in this volume.
Coenzyme Q10
Coenzyme Q10: Uses, Health Effects and Role in Disease reviews the current knowledge and evidence of the potential clinical applications of Coenzyme Q10 (CoQ10). CoQ10 is a lipophilic molecule composed by a bezonquinone ring conjugated to a ten-carbon isoprenoid side chain. It exists in two molecular forms, ubiquinone and ubiquinol, which are the basis for its antioxidant properties. CoQ10 also plays an essential role in cellular metabolism to produce ATP, which provides energy for muscle contraction and other vital cellular functions. Most of the ATP production occurs in the inner mitochondrial membrane, where coenzyme Q is found. The authors review the protective effects of CoQ10 on intense physical exercise, reducing muscle damage and improving physical performance. Evidence of secondary CoQ10 deficiency in disease and in pharmacotherapy is discussed, highlighting putative mechanisms to account for this deficit together with examples of therapeutic intervention. Secondary CoQ10 deficiencies are important to identify as clinical benefit can be elicited following treatment with CoQ10 or its associated analogues.
Biochemistry (2 Volume Set)
Biochemistry: The Chemical Reactions of Living Cells is a well-integrated, up-to-date reference for basic biochemistry, associated chemistry, and underlying biological phenomena. Biochemistry is a comprehensive account of the chemical basis of life, describing the amazingly complex structures of the compounds that make up cells, the forces that hold them together, and the chemical reactions that allow for recognition, signaling, and movement. This book contains information on the human body, its genome, and the action of muscles, eyes, and the brain. * Thousands of literature references provide introduction to current research as well as historical background * Contains twice the number of chapters of the first edition * Each chapter contains boxes of information on topics of general interest
