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Transgenic Models in Pharmacology
Up-to-date information on animal models generated by transgenic or gene targeting techniques. Naturally, the focus is on the mouse system. Each chapter has been written by leading experts in the field and gives an overview on existing animal models. This is facilitated by tables, which list the most important genetically engineered animal models and their phenotypes. This book aims at illustrating the impact of transgenic animal models in the field of Experimental Pharmacology and Toxicology, which includes their role in the understanding of basic cellular mechanisms, the evaluation of potential drug targets or the testing for drug effects.
Augmentation of Brain Function: Facts, Fiction and Controversy
The final volume in this tripartite series on Brain Augmentation is entitled “From Clinical Applications to Ethical Issues and Futuristic Ideas”. Many of the articles within this volume deal with translational efforts taking the results of experiments on laboratory animals and applying them to humans. In many cases, these interventions are intended to help people with disabilities in such a way so as to either restore or extend brain function. Traditionally, therapies in brain augmentation have included electrical and pharmacological techniques. In contrast, some of the techniques discussed in this volume add specificity by targeting select neural populations. This approach opens the doo...
The Sugar Code
A reader friendly overview of the structure and functional relevance of natural glycosylation and its cognate proteins (lectins), this book is also one of the few books to cover their role in health and disease. Edited by one of the pioneering experts in the field and written by a team of renowned researchers this resource is a perfect introduction for all students in life and medical sciences, biochemistry, chemistry and pharmacy. Website: WWW.WILEY-VCH.DE/HOME/THESUGARCODE
The Auditory Cortex
There has been substantial progress in understanding the contributions of the auditory forebrain to hearing, sound localization, communication, emotive behavior, and cognition. The Auditory Cortex covers the latest knowledge about the auditory forebrain, including the auditory cortex as well as the medial geniculate body in the thalamus. This book will cover all important aspects of the auditory forebrain organization and function, integrating the auditory thalamus and cortex into a smooth, coherent whole. Volume One covers basic auditory neuroscience. It complements The Auditory Cortex, Volume 2: Integrative Neuroscience, which takes a more applied/clinical perspective.
Extracellular ATP and adenosine as regulators of endothelial cell function
Extracellular purines and pyrimidines (ATP, ADP, UTP and adenosine) are released into the extracellular milieu in response to a variety of stress conditions and act as important regulators of vascular homeostasis. This new book is uniquely focused on the signaling actions of extracellular purines in endothelial cells and the crucial role of extracellular purines in regulation of angiogenesis, vascular tone, cell permeability, wound healing, inflammation and cell-to-cell communication. This book examines the responses of endothelial cells, originating from various tissues (such as cornea, pancreas and uterus), to extracellular nucleotides and adenosine under physiological and pathological con...
Handbook of Parallel Constraint Reasoning
This is the first book presenting a broad overview of parallelism in constraint-based reasoning formalisms. In recent years, an increasing number of contributions have been made on scaling constraint reasoning thanks to parallel architectures. The goal in this book is to overview these achievements in a concise way, assuming the reader is familiar with the classical, sequential background. It presents work demonstrating the use of multiple resources from single machine multi-core and GPU-based computations to very large scale distributed execution platforms up to 80,000 processing units. The contributions in the book cover the most important and recent contributions in parallel propositional...
How and Why Does Spatial-Hearing Ability Differ among Listeners? What Is the Role of Learning and Multisensory Interactions?
Spatial-hearing ability has been found to vary widely across listeners. A survey of the existing auditory-space perception literature suggests that three main types of factors may account for this variability: - physical factors, e.g., acoustical characteristics related to sound-localization cues, - perceptual factors, e.g., sensory/cognitive processing, perceptual learning, multisensory interactions, - and methodological factors, e.g., differences in stimulus presentation methods across studies. However, the extent to which these–and perhaps other, still unidentified—factors actually contribute to the observed variability in spatial hearing across individuals with normal hearing or with...
The Functional Organization of the Auditory System
This eBook comprises s series of original research and review articles dealing with the anatomical, genetic, and physiological organization of the auditory system from humans to monkeys and mice.
ROCK PLANET
Die Rockmusik der Sechziger, Siebziger und Achtziger des letzten Jahrhunderts hat mehrere Generationen beeinflusst und wirkt bis heute nach. In dieser Anthologie setzen die Autoren ihren Helden ein Denkmal und gestatten auch private Einblicke darüber, wie die Rockmusik sie gefunden hat. Alle waren sich einig, dass nicht wir die Musik, sondern die Musik uns gefunden hat und findet. Die Geschichten in dieser Anthologie wurden von Songs der Bands Free, Led Zeppelin, Iron Maiden, Black Sabbath, Uriah Heep, AC/DC, The Who, Deep Purple, Golden Earring und anderen inspiriert. Titelbild und Illustrationen von: Uli Bendick, sowie weitere Illustrationen von Mario Franke, Frank G. Gerigk, Veith Kanoder-Brunnel, Detlef Klewer, Marianne Labisch und Andreas Schwietzke.
