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Dna Polymerases: Discovery, Characterization And Functions In Cellular Dna Transactions
  • Language: en
  • Pages: 338

Dna Polymerases: Discovery, Characterization And Functions In Cellular Dna Transactions

Maintenance of the information embedded in the genomic DNA sequence is essential for life. DNA polymerases play pivotal roles in the complex processes that maintain genetic integrity. Besides their tasks in vivo, DNA polymerases are the workhorses in numerous biotechnology applications such as the polymerase chain reaction (PCR), cDNA cloning, genome sequencing, nucleic acids-based diagnostics and in techniques to analyze ancient and otherwise damaged DNA. Moreover, some diseases are related to DNA polymerase defects, and chemotherapy through inhibition of DNA polymerases is used to fight HIV, Herpes and Hepatitis B and C infections. We have recently witnessed the discovery of an abundance of novel DNA polymerases in viruses, bacteria, archaea and eukaryotes with specialized properties whose physiological functions are only beginning to be understood. This book summarizes the current knowledge of these fascinating enzymes. It is intended for a wide audience from basic scientists, to diagnostic laboratories and to clinicians who seek a better understanding of these fascinating enzymes.

Notes and Queries
  • Language: en
  • Pages: 604

Notes and Queries

  • Type: Book
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  • Published: 1891
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  • Publisher: Unknown

None

Human Dna Polymerases: Biology, Medicine And Biotechnology
  • Language: en
  • Pages: 398

Human Dna Polymerases: Biology, Medicine And Biotechnology

Maintenance of the information embedded in the genomic DNA sequence is essential for life. DNA polymerases play pivotal roles in the complex processes that maintain genetic integrity. Besides their tasks in vivo, DNA polymerases are the workhorses in numerous biotechnology applications such as the polymerase chain reaction (PCR), cDNA cloning, next generation sequencing, nucleic acids based diagnostics and in techniques to analyze ancient and otherwise damaged DNA (e.g. for forensic applications). Moreover, some diseases are related to DNA polymerase defects and chemotherapy through inhibition of DNA polymerases is used to fight HIV, Herpes and Hepatitis B and C infections. This book focuses on (i) biology of DNA polymerases, (ii) medical aspects of DNA polymerases and (iii) biotechnological applications of DNA polymerases. It is intended for a wide audience from basic scientists, to diagnostic laboratories, to companies and to clinicians, who seek a better understanding and the practical use of these fascinating enzymes.

History of the Evangelical Lutheran Synod of East Pennsylvania
  • Language: en
  • Pages: 400
Replication of Viral and Cellular Genomes
  • Language: en
  • Pages: 379

Replication of Viral and Cellular Genomes

Biosynthesis of cellular and viral DNA and RNA has been a major topic in molecular biology and biochemistry. The studies by Arthur Kornberg and his colleagues on the in-vitro synthesis of DNA have opened new avenues to understanding the processes controlling the duplication of the genetic information encoded in the DNA and RNA of bacterial and mammalian cells. Viral nucleic acids are replicated in infected cells (bacterial, plant, and animal) by virus coded enzymes with or without the involvement of proteins and enzymes coded by the host cells. The ability of the virus to replicate its genome within a relatively short period in the infected cell makes it an excellent biological tool for stud...

Nature Encyclopedia of the Human Genome: Renal carcinoma and von Hippel-Lindau disease - Zuckerkandl, Emile
  • Language: en
  • Pages: 1066
Current Catalog
  • Language: en
  • Pages: 1712

Current Catalog

  • Type: Book
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  • Published: Unknown
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  • Publisher: Unknown

First multi-year cumulation covers six years: 1965-70.

The Introduction, Contestation, and Regulation of Forensic DNA Analysis in the American Legal System (1984-1994)
  • Language: en
  • Pages: 648
Directory of Published Proceedings
  • Language: en
  • Pages: 986

Directory of Published Proceedings

  • Type: Book
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  • Published: 1984
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  • Publisher: Unknown

None

EJB Reviews 1990
  • Language: en
  • Pages: 280

EJB Reviews 1990

In the mid-1980s the European Journal of Biochemistry set out to publish review articles. The enterprise proved successful resulting in high-level reviews written by well-known scientists appearing in the Journal. The reviews represent emerging and rapidly growing fields of research in fundamental as well as applied areas of biochemistry, such as medicine, biotechnology, agriculture and nutrition. Novel methodological and technological approaches which stimulate biochemical research are also included. The authors of the reviews are explicitly asked to be critical, selective, evaluative and interdisciplinarily oriented. The reviews should encourage young scientists toward independent and creative thinking, and inform active investigators about the state of the art in a given field.