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Dna Polymerases: Discovery, Characterization And Functions In Cellular Dna Transactions
  • Language: en
  • Pages: 338

Dna Polymerases: Discovery, Characterization And Functions In Cellular Dna Transactions

Maintenance of the information embedded in the genomic DNA sequence is essential for life. DNA polymerases play pivotal roles in the complex processes that maintain genetic integrity. Besides their tasks in vivo, DNA polymerases are the workhorses in numerous biotechnology applications such as the polymerase chain reaction (PCR), cDNA cloning, genome sequencing, nucleic acids-based diagnostics and in techniques to analyze ancient and otherwise damaged DNA. Moreover, some diseases are related to DNA polymerase defects, and chemotherapy through inhibition of DNA polymerases is used to fight HIV, Herpes and Hepatitis B and C infections. We have recently witnessed the discovery of an abundance of novel DNA polymerases in viruses, bacteria, archaea and eukaryotes with specialized properties whose physiological functions are only beginning to be understood. This book summarizes the current knowledge of these fascinating enzymes. It is intended for a wide audience from basic scientists, to diagnostic laboratories and to clinicians who seek a better understanding of these fascinating enzymes.

Replication of Viral and Cellular Genomes
  • Language: en
  • Pages: 379

Replication of Viral and Cellular Genomes

Biosynthesis of cellular and viral DNA and RNA has been a major topic in molecular biology and biochemistry. The studies by Arthur Kornberg and his colleagues on the in-vitro synthesis of DNA have opened new avenues to understanding the processes controlling the duplication of the genetic information encoded in the DNA and RNA of bacterial and mammalian cells. Viral nucleic acids are replicated in infected cells (bacterial, plant, and animal) by virus coded enzymes with or without the involvement of proteins and enzymes coded by the host cells. The ability of the virus to replicate its genome within a relatively short period in the infected cell makes it an excellent biological tool for stud...

History of the Evangelical Lutheran Synod of East Pennsylvania
  • Language: en
  • Pages: 400
Human Dna Polymerases: Biology, Medicine And Biotechnology
  • Language: en
  • Pages: 398

Human Dna Polymerases: Biology, Medicine And Biotechnology

Maintenance of the information embedded in the genomic DNA sequence is essential for life. DNA polymerases play pivotal roles in the complex processes that maintain genetic integrity. Besides their tasks in vivo, DNA polymerases are the workhorses in numerous biotechnology applications such as the polymerase chain reaction (PCR), cDNA cloning, next generation sequencing, nucleic acids based diagnostics and in techniques to analyze ancient and otherwise damaged DNA (e.g. for forensic applications). Moreover, some diseases are related to DNA polymerase defects and chemotherapy through inhibition of DNA polymerases is used to fight HIV, Herpes and Hepatitis B and C infections. This book focuses on (i) biology of DNA polymerases, (ii) medical aspects of DNA polymerases and (iii) biotechnological applications of DNA polymerases. It is intended for a wide audience from basic scientists, to diagnostic laboratories, to companies and to clinicians, who seek a better understanding and the practical use of these fascinating enzymes.

Annual Review of Biochemistry
  • Language: en
  • Pages: 1088

Annual Review of Biochemistry

  • Type: Book
  • -
  • Published: 2002-06
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  • Publisher: Unknown

Representing one year's progress in the field of biochemistry, this volume presents 27 papers on topics like Vitamin B-12, error-prone repair, long-distance electron transfer, V(D)J recombination, eukaryotic DNA polymerizes, DNA replication, enzymology, nucleotide remodeling, metabolism, lipoprotein receptors, structure and autoregulation in cellular function, mammalian ABC transporters, lipopolysaccharide endotoxins, unusual sugars, nuclear actin, fast protein folding, RNA editing, and catalytic proficiency. An abstract accompanies each paper and numerous diagrams (a few in color) illustrate the concepts described. Annotation copyrighted by Book News, Inc., Portland, OR

IBZ (kombinierte Folge)
  • Language: en
  • Pages: 696

IBZ (kombinierte Folge)

  • Type: Book
  • -
  • Published: 1981
  • -
  • Publisher: Unknown

None

Proceedings of the National Academy of Sciences of the United States of America
  • Language: en
  • Pages: 1384

Proceedings of the National Academy of Sciences of the United States of America

  • Type: Book
  • -
  • Published: 2004
  • -
  • Publisher: Unknown

None

Encyclopedia of Environmental Biology
  • Language: en
  • Pages: 1006

Encyclopedia of Environmental Biology

  • Type: Book
  • -
  • Published: 1995
  • -
  • Publisher: Unknown

None

Abstracts, 12th Annual UCLA Symposia, March 27-April 30, 1983
  • Language: en
  • Pages: 440

Abstracts, 12th Annual UCLA Symposia, March 27-April 30, 1983

  • Type: Book
  • -
  • Published: 1982
  • -
  • Publisher: Unknown

None

EJB Reviews
  • Language: en
  • Pages: 640

EJB Reviews

  • Type: Book
  • -
  • Published: 1990
  • -
  • Publisher: Unknown

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