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The Physiological Functions of the Amyloid Precursor Protein Gene Family
The amyloid precursor protein APP plays a key role in the pathogenesis of Alzheimer’s disease (AD), as proteolytical cleavage of APP gives rise to the Aβ peptide which is deposited in the brains of Alzheimer patients. Despite this, our knowledge of the normal cell biological and physiological functions of APP and the closely related APLPs is limited. This may have hampered our understanding of AD, since evidence has accumulated that not only the production of the Aβ peptide but also the loss of APP-mediated functions may contribute to AD pathogenesis. Thus, it appears timely and highly relevant to elucidate the functions of the APP gene family from the molecular level to their role in th...
Dementia Reimagined
The cultural and medical history of dementia and Alzheimer's disease by a leading psychiatrist and bioethicist who urges us to turn our focus from cure to care. Despite being a physician and a bioethicist, Tia Powell wasn't prepared to address the challenges she faced when her grandmother, and then her mother, were diagnosed with dementia--not to mention confronting the hard truth that her own odds aren't great. In the U.S., 10,000 baby boomers turn 65 every day; by the time a person reaches 85, their chances of having dementia approach 50 percent. And the truth is, there is no cure, and none coming soon, despite the perpetual promises by pharmaceutical companies that they are just one more ...
Visual Coexistence
In a globalized world, Asian, Latin and Arabic characters and visual cultures appear side by side and woven together. The coexistence of different visual cultures is now part of our daily lives and a given feature of our communication systems. But how do we best present information, structures and designs from different linguistic and cultural backgrounds? Visual communication has classically been guided by principles of uniformity and simplification, values that seem unable to adequately cope with the coexistence of different systems of representation. How can we set up equitable systems for cross-cultural communication that honor the diversity of writing systems? What new design values are...
Steuerstrafrecht und Steuerstrafverfahren
Das beste Strafverfahren ist das Verfahren, welches nicht stattfindet. Steuerliche Beratung unter dem Aspekt strafrechtlicher Risikovermeidung ist daher ein Schwerpunkt des Werks. Das Werk deckt zudem auch das materielle Steuerstrafrecht ab, so dass das Buch zum wertvollen Berater für die Praxis wird.
Dynamic Identities in Cultural and Public Context
This publication studies methods for creating flexible looks for public and cultural institutions. The conventional logos traditionally used by companies are the result of a unique process of compression and abstraction. By contrast, flexible looks do not conceal their diverse components in their logo but instead from a complex family of symbols from them. In the combination of a basic logo and a family of symbols, the look is in a position to represent the general (the philosophy of the institution, the program) and the specific (e.g., changing exhibitions and events). The author describes the effect and potential of looks and offers general criteria that distinguish fully developed, dynamic looks. The subject is also presented in the form of artistic projects and with reference examples from the natural sciences and the humanities. Case studies of famous designers such as Karl Gerstner and Ruedi Baur enhance the analysis
100 Years of Swiss Graphic Design
This title takes a fresh look at Swiss typography and photo-graphics, posters, corporate image design, book design, journalism, and typefaces over the past hundred years. With illuminating essays by prominent experts in the field and captivating illustrations, this book presents the diversity of contemporary visual design while also tracing the fine lines of tradition that connect the work of different periods.
Speaker Classification I
This volume and its companion volume LNAI 4441 constitute a state-of-the-art survey in the field of speaker classification. Together they address such intriguing issues as how speaker characteristics are manifested in voice and speaking behavior. The nineteen contributions in this volume are organized into topical sections covering fundamentals, characteristics, applications, methods, and evaluation.
Explaining Federalism
This book deals with the theoretical and empirical questions of federalism in the context of five case studies: Austria, Belgium, Canada, Germany and Switzerland. The central argument is that in the long run the political institutions of federalism adapt to achieve congruence with the underlying social structure. This change could be in the centralist direction reflecting ethno-linguistic homogeneity, or in decentralist terms corresponding to ethno-linguistic heterogeneity. In this context, the volume: fills a gap in the comparative federalism literature by analyzing the patterns of change and continuity in five federal systems of the industrial west, this is done by an in-depth empirical examination of the case studies through a single framework of analysis illustrates the shortcomings of new-institutionalist approaches in explaining change, highlighting the usefulness of society-based approaches in studying change and continuity in comparative politics. Explaining Federalism will be of interest to students and scholars of federalism, comparative government, comparative institutional analysis and comparative public policy.
