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Neural Repair
This detailed collection explores a diverse range of topics related to neural repair and functional recovery following ischemic stroke. Techniques detailed in this book span from basic to emerging approaches used to evaluate hallmarks of neurorepair, including axonal remodeling and dendritic arborization, plasticity and functional connectivity, angiogenesis, neuroinflammation, and recovering cerebral blood flow. In addition, several chapters focus on rodent stroke models and post-stroke functional evaluation, clinically-relevant therapeutic paradigms and co-morbidities, pharmacotherapy and methods of delivery. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, as well as tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Neural Repair: Methods and Protocols serves as an ideal guide for the wide community of researchers interested in neurorepair following stroke and other forms of CNS injury.
Brody's Human Pharmacology
Brody’s Human Pharmacology is a well-established and much-loved textbook that guides students of medicine, pharmacology and other health professions through pharmacology from both basic and clinical perspectives. What can be a very difficult and complex topic is divided into easily digestible chapters, each of which is clearly structured from a therapeutic overview to mechanisms of action, relationships to clinical responses, pharmacokinetics, pharmacovigilance, new developments, and clinical relevance for all health professionals. Contains all the essential aspects of pharmacology – suitable for exam preparation Full color illustrations explain important processes and color-coded boxes ...
Broken Movement
An account of the neurobiology of motor recovery in the arm and hand after stroke by two experts in the field. Stroke is a leading cause of disability in adults and recovery is often difficult, with existing rehabilitation therapies largely ineffective. In Broken Movement, John Krakauer and S. Thomas Carmichael, both experts in the field, provide an account of the neurobiology of motor recovery in the arm and hand after stroke. They cover topics that range from behavior to physiology to cellular and molecular biology. Broken Movement is the only accessible single-volume work that covers motor control and motor learning as they apply to stroke recovery and combines them with motor cortical ph...
Intelligent Hydrogels in Diagnostics and Therapeutics
This book explores the potential of hydrogels as a multiutility system and their benefits (biocompatibility, degradability, and supporting scaffolds) for a wide range of applications in diagnostics and therapeutics. It also discusses the future prospects and challenges facing hydrogels. A wide variety of smart hydrogels (conducting, stimuli responsive, and others) with possible biomedical applications are elaborated. The book demonstrates the effectiveness of hydrogels in diagnostics of diseases in various in vivo and in vitro environments and highlights the engineering/functionalization of hydrogels for everyday drug dosage as an efficient drug carrier, scaffold, and sensing application. Ex...
Bone Regeneration: Concepts, Clinical Aspects and Future Directions
Bone regeneration is a complex process requiring an orchestrated number of molecular and cellular mechanisms. Although bone regeneration takes place throughout a lifetime for normal healing, regeneration may be impaired by pathological states such as osteoporosis, osteonecrosis, and non-union fractures. Currently, a number of therapies are available for treating pathogenesis, such as autologous bone grafts, small molecule agents, tissue engineering, and the use of osteoprogenitor cells. Other therapies including small compounds, growth factors, and cytokines are being used for a targeted approach. Orthobiologics are also being used for healing bones. The use of mesenchymal stem cells and ost...
Recovery After Stroke
Covering neuroscience and rehabilitation strategies, an essential handbook and reference for multidisciplinary stroke rehabilitation teams.
Neuroprotection in Alzheimer's Disease
Neuroprotection in Alzheimer’s Disease offers a translational point-of-view from both basic and clinical standpoints, putting it on the cusp for further clinical development with its emphasis on nerve cell protection, including the accumulation of knowledge from failed clinical trials and new advances in disease management. This book brings together the latest findings, both basic, and clinical, under the same cover, making it easy for the reader to obtain a complete overview of the state-of-the-field and beyond. Alzheimer's disease is the most common form of dementia, accounting for 60 to 80 percent of dementia cases. It is a progressive brain disease that slowly destroys memory, thinking...
Brucella Melitensis
Brucella Miletensis: Identification and Characterization of Potential Drug Targets presents a systematic approach to identifying and characterizing drug targets using bioinformatics. The book shows the potential of bioinformatic tools in the identification of virulence targets in pathogenic bacteria and viruses, in general, and in B. militensis 16M in particular. Chapters identify putative genes as potential drug targets, employ a subtractive genomic approach, consider the virulent genes of this bacteria that negatively affects humans, list twelve potential virulence genes as drug targets, and consider the screening of potential drugs against the bacteria’s virulence genes through molecula...
Cardiac Pacing and ICDs
Fully revised and updated, the fourth edition of Cardiac Pacingand ICDs continues to be an accessible and practical clinicalreference for residents, fellows, surgeons, nurses, PAs, andtechnicians. The chapters are organized in the sequence of the evaluation ofan actual patient, making it an effective practical guide. Revisedchapters and updated artwork and tables plus a new chapter oncardiac resynchronization make the new edition an invaluableclinical resource. Features: · New chapter on Cardiac Resynchronization Therapy · Updated and better quality figures and tables · Updated content based on ACC/AHA/NASPE guidelines · Updated indications for ICD placement · Updated information on ICD and pacemakertroubleshooting
