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Behavioral Neurobiology of PTSD
This volume focuses on the behavioral neuroscience that supports our understanding of the neurobiology of trauma risk and response. The collection of articles focuses on both preclinical and clinical reviews of (1) state-of-the-art knowledge of mechanisms of posttraumatic stress disorder (PTSD) and co-occurring disorders, (2) the biological and psychological constructs that support risk and resiliency for trauma disorders, and (3), novel treatment strategies and therapeutics on the horizon.
Anhedonia: Preclinical, Translational, and Clinical Integration
Anhedonia is a key symptom (and often risk factor) for various neuropsychiatric disorders, including depression, schizophrenia, substance use disorders, post-traumatic stress disorders, and Parkinson's Disease, among others. Across disorders, anhedonia has been associated with worse disease course, including poor response to pharmacological, psychological and neurostimulation treatments as well as completed suicide. Mounting evidence emerging from preclinical and translational sciences has clarified that "anhedonia" can be parsed into partially independent subcomponents, including incentive motivation, consummatory pleasure, reward learning, and effort-based decision making, pointing to dist...
The LDN Book, Volume Two
A drug that is simultaneously affordable, devoid of severe side effects, and applicable to a wide range of diseases is one not often found in the modern pharmaceutical landscape. But as medical professionals and researchers alike have found, Low Dose Naltrexone (LDN) boasts this remarkable combination. LDN, originally prescribed in higher doses as a treatment for opioid addiction, works by blocking opioid receptors, thereby stimulating the production of endorphins, mitigating the inflammatory process, and stabilizing the immune response. Prescribed off-label and administered in small daily doses, this generic drug has proven useful in treating many different ailments. Expanding on the inform...
Behavioral Neurobiology of Anxiety and Its Treatment
The book is part of a series on Current Topics in Behavioral Neurosciences, which has as its focus anxiety and its treatment. We have brought together a distinguished cadre of authors with the aim of covering a broad array of topics related to anxiety disorders, ranging from clinical diagnosis, epidemiology, preclinical neuroscience, and animal models to established and innovative therapeutic approaches. The book aims at bridging these disciplines to provide an update of literature relevant to understanding anxiety, its consequences, and its management. Following is a brief overview of the chapters and their content, meant to serve as a guide to navigating the book. The ?rst section covers c...
Translational Neuropsychopharmacology
This book covers wide areas of animal and human psychopharmacology with clinical utility in the treatment of psychiatric and neurological (e.g Alzheimer's disease) disorders. The main theme is to develop a new paradigm for drug discovery that questions the claim that animal models or assays fail adequately to predict Phase 3 clinical trials. A new paradigm is advocated that stresses the importance of intermediate staging points between these extremes that depend on suitable translation of findings from animal studies to Phase 1 or Phase 2 studies utilising experimental medicine.
Oxford Handbook of Anxiety and Related Disorders
This handbook reviews research and clinical developments through synthetic chapters written by experts from various fields of study and clinical backgrounds. It discusses each of the main anxiety disorders and examines diagnostic criteria, prevalence rates, comorbidity, and clinical issues.
Biobehavioral Resilience to Stress
Military service involves exposure to multiple sources of chronic, acute, and potentially traumatic stress, especially during deployment and combat. Notoriously variable, the effects of stress can be subtle to severe, immediate or delayed, impairing individual and group readiness, operational performance, and ultimately‘survival. A comprehensive co
