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Modified Nucleic Acids in Biology and Medicine
This volume is comprised of 18 chapters, covering various aspects of DNA modification and RNA modified bases. It also discusses in detail circular RNA, therapeutic oligonucleotides and their different properties. The chemical nature of DNA, RNA, protein and lipids makes these macromolecules easily modifiable, but they are also susceptible to damage from both endogenous and exogenous agents. Alkylation and oxidation show a potential to disrupt the cellular redox equilibrium and cause cellular damage leading to inflammation and even chronic disease. Furthermore, DNA damage can drive mutagenesis and the resulting DNA sequence changes can induce carcinogenesis and cancer progression. Modified nu...
Modified Nucleic Acids
This book spans diverse aspects of modified nucleic acids, from chemical synthesis and spectroscopy to in vivo applications, and highlights studies on chemical modifications of the backbone and nucleobases. Topics discussed include fluorescent pyrimidine and purine analogs, enzymatic approaches to the preparation of modified nucleic acids, emission and electron paramagnetic resonance (EPR) spectroscopy for studying nucleic acid structure and dynamics, non-covalent binding of low- and high-MW ligands to nucleic acids and the design of unnatural base pairs. This unique book addresses new developments and is designed for graduate level and professional research purposes.
Valency over Time
Valency patterns and valency orientation have been frequent topics of research under different perspectives, often poorly connected. Diachronic studies on these topics is even less systematic than synchronic ones. The papers in this book bring together two strands of research on valency, i.e. the description of valency patterns as worked out in the Leipzig Valency Classes Project (ValPaL), and the assessment of a language's basic valency and its possible orientation. Notably, the ValPaL does not provide diachronic information concerning the valency patterns investigated: one of the aims of the book is to supplement the available data with data from historical stages of languages, in order to make it profitably exploitable for diachronic research. In addition, new research on the diachrony of basic valency and valency alternations can deepen our understanding of mechanisms of language change and of the propensity of languages or language families to exploit different constructional patterns related to transitivity.
Jewish Women in the Early Italian Women’s Movement, 1861–1945
This book is the first epoch-spanning study on Jewish participation in the Italian women’s movement, focussing in a transnational perspective on the experience of Italian-Jewish protagonists in Liberal Italy, during the First World War and the Fascist dictatorship until 1945. Drawing on ego-documents, contemporary journals and Jewish community archives, as well as records by the police and public authorities, it examines the tensions within the emancipation process between participation and exclusion. The book argues that the racial laws from 1938 did not represent the sudden end of an idyllic integration, but rather the climax of a long-term development. Social marginalization, the persecution of Jewish rights, and the assault on Jewish lives during fascism are analysed distinctly from the perspective of Jewish women. In spite of their significant influence on the transnational orientation of the Italian women’s movement, their emancipation as women and Jews remained incomplete.
Methods in Protein Sequence Analysis
Methods in protein sequence analysis constitute important fields in rapid progress. We have experienced a continuous increase in analytical sensitivity coupled with decreases in time necessary for purification and analysis. Several generations of sequencers, liquid/solid/gas-phase, have passed by and returned in other shapes during just over two decades. Similarly, the introduction of HPLC permitted an enormous leap forward in this as in other fields of biochemistry, and we now start to see new major advances in purification/analysis through capillary electrophoresis. Furthermore, progress in the field of mass spectrometry has matched that in chemical analysis and we witness continuous devel...
Germany's Aims in the First World War
A scholarly interpretation of Germany's policies and attitudes during the first World War and their profound effect on subsequent world events
Fishers' Knowledge in Fisheries Science and Management
Drawing on a number of case studies from around the world, this publication considers how the local knowledge and practices of indigenous fishing communities are being used in collaboration with scientists, government managers and non-governmental organisations to establish effective frameworks for sustainable fisheries science and management. It seeks to contribute towards achieving the goal of establishing international responsibility for the ethical collection, preservation, dissemination and application of fishers' knowledge.
Transnational German Cinema
This volume explores the notion of German cinema as both a national and increasingly transnational entity. It brings together chapters that analyse the international circuits of development and distribution that shape the emerging films as part of a contemporary “German cinema”, the events and spectacles that help frame and re-frame national cinemas and their discoverability, and the well-known filmmakers who sit at the vanguard of the contemporary canon. Thereby, it explores what we understand as German cinema today and the many points where this idea of national cinema can be interrogated, expanded and opened up to new readings. At the heart of this interrogation is a keen awareness of...
The Path to the Double Helix
Written by a noted historian of science, this in-depth account traces how Watson and Crick achieved one of science's most dramatic feats: their 1953 discovery of the molecular structure of DNA.
