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Ever since arbovirus infections became known and their relative importance assessed, experiments were designed to elucidate the mode of transmission and the most important natural hosts responsible for perpetuating the infection in nature. Human infections and the disease in wild rodents, birds, and domestic animals were studied in relation to viremia and distribution of the infectious agent in the organism. With increasing epidemiological studies it became apparent that the neural manifestations of the disease are very uncommon, confined only to a small percentage of individuals of the most susceptible species. Various factors have been proposed to explain why in certain instances the virus becomes establish ed in the central nervous system and causes a serious or lethal disease. For example, differences in the virulence of the virus strains, varying susceptibility of individuals of one species, or intercurrent circumstances facilitating access of the virus to the central nervous system were alleged. Also, various possible routes of entry of the virus into the brain and spinal cord have been considered.
PROGRESS IN MEDICINAL CHEMISTRY 7.
This volume contains seven chapters, based on papers presented at a Symposium on Insect Viruses, held in conjunction with the 67th Annual Meeting of the American Society for Microbiology in New York, N. Y. , on 30 April-4 May, 1967. The Symposium was organized to bring together outstanding workers interested in various areas of insect virology, and allow an opportunity for a discussion of problems, approaches, and methods that would lead to further progress in basic and applied research. One of the princi pal reasons for holding the Symposium at this time was the feeling that the divergent areas of research, up to now studied separately by entomologists, medical and public health workers, ge...
A chronicle written only by someone for whom the present important. Goethe, Maximen und Reflexionen The second volume of our company's history differs from the first in several ways. With a great appreciation of history, Heinz Sarkowski has impressively reconstructed the company cor- spondence, which is fortunately almost completely preserved, and made it speak. * There is an inexhaustible amount of c- respondence pertaining to the period I have taken it upon myself to cover, and working through it properly not only would have required many years, but also would have detracted from the immediacy of the account. Thus, I decided to proceed from personal experience, to describe what has happene...