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Ein Werk in transparenter Klarheit und geometrischer Ordnung hat Wiel Arets zu einem der einflussreichsten Architekten Europas gemacht. In der Tradition Louis I. Kahns wahren seine Werke trotz ihrer Strenge einen menschlichen Maßstab: sie wirken kraftvoll, aber nicht anmaßend. Arets‘ großes Interesse gilt der Hülle des Gebäudes: Als Membran bestimmt sie je nach Wahl der innovativen Materialien das Maß der Durchlässigkeit und wirkt als Filter. Damit einher geht eine große Sensibilität für den urbanen Kontext. Das Buch stellt Arets‘ wichtigste Bauten und Projekte vor, unter ihnen die Akademie für Kunst und Architektur in Maastricht, das Hauptgebäude der AZL Pensionskasse in Heerlen sowie einige neuere Projekte, die hier erstmals veröffentlicht werden. Eine Auswahl aus Arets‘ eigenen Schriften sowie kritische Essays von Xavier Costa, Anthony Vidler, Greg Lynn, Stan Allen und Bart Lootsma ergänzen diese Werkdokumentation. Die Fotografien stammen von Hélène Binet.
(Reis)gids voor moderne Nederlandse architectuur waarin ruim 700 objecten worden afgebeeld en beknopt beschreven.
A comprehensive work on the European space sector.
This volume describes the pathogenesis and pathophysiology of several pulmonary diseases as well as their treatment. It also discusses the underlying genetic and molecular biological basis, which opens the way for new treatments for these conditions. It focuses on the treatment of cystic fibrosis including CFTR (cystic fibrosis transmembrane-conductance regulator) modulator therapies, drug therapies that augment airway surface liquid as well as anti-inflammatory and anti-infective therapies. Further topics include long-term, low-dose macrolide therapy for diffuse panbronchiolitis; novel agents for previously untreatable idiopathic pulmonary fibrosis; possible new treatments for pulmonary alveolar proteinosis (PAP); and multiple novel therapeutic targets for treating lymphangiomyomatosis. Research into these conditions has led to major advances in our understanding of the underlying genetic and molecular basis of this disease, and to dramatic improvements in survival and quality of life for affected individuals.
Containing over 300 entries, this guide presents an overview of the most recent developments in Dutch architecture and urban design from the 1980s to the present day. Its compact shape, practical layout and extensive indexes make this guide an indispensable source of inspiration and reference work on the practice of Dutch architecture today. Includes work by Koolhaas, Mecanoo, Arets, van Berkel, van Egeraat, Foster, De Geyter, Hertzberger, Krier, MVRDV, Neutelings Riedijk, Graves, Benthem Crouwel, Nox, and many others.
This book provides an authoritative review of fetal and neonatal lung development, and is designed to provide diverse groups of scientists, spanning the basic to clinical research spectrum, with the latest developments on the cellular and molecular mechanisms of normal lung development and injury-repair processes, and how they are dysregulated in disease.