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Positioning Synthetic Biology to Meet the Challenges of the 21st Century
Synthetic biology-unlike any research discipline that precedes it-has the potential to bypass the less predictable process of evolution to usher in a new and dynamic way of working with living systems. Ultimately, synthetic biologists hope to design and build engineered biological systems with capabilities that do not exist in natural systems-capabilities that may ultimately be used for applications in manufacturing, food production, and global health. Importantly, synthetic biology represents an area of science and engineering that raises technical, ethical, regulatory, security, biosafety, intellectual property, and other issues that will be resolved differently in different parts of the w...
Medical Image Computing and Computer Assisted Intervention – MICCAI 2022
The eight-volume set LNCS 13431, 13432, 13433, 13434, 13435, 13436, 13437, and 13438 constitutes the refereed proceedings of the 25th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2022, which was held in Singapore in September 2022. The 574 revised full papers presented were carefully reviewed and selected from 1831 submissions in a double-blind review process. The papers are organized in the following topical sections: Part I: Brain development and atlases; DWI and tractography; functional brain networks; neuroimaging; heart and lung imaging; dermatology; Part II: Computational (integrative) pathology; computational anatomy and physiology; op...
The microbial sulfur cycle
Sulfur is the tenth most abundant element in the universe and the sixth most abundant element in microbial biomass. By virtue of its chemical properties, particularly the wide range of stable redox states, sulfur plays a critical role in central biochemistry as a structural element, redox center, and carbon carrier. In addition, redox reactions involving reduced and oxidized inorganic sulfur compounds can be utilized by microbes for the generation and conservation of biochemical energy. Microbial transformation of both inorganic and organic sulfur compounds has had a profound effect on the properties of the biosphere and continues to affect geochemistry today. For these reasons, we present here a collection of articles from the leading edge of the field of sulfur microbiology, focusing on reactions and compounds of geochemical significance.
Stress and Environmental Regulation of Gene Expression and Adaptation in Bacteria, 2 Volume Set
Bacteria in various habitats are subject to continuously changing environmental conditions, such as nutrient deprivation, heat and cold stress, UV radiation, oxidative stress, dessication, acid stress, nitrosative stress, cell envelope stress, heavy metal exposure, osmotic stress, and others. In order to survive, they have to respond to these conditions by adapting their physiology through sometimes drastic changes in gene expression. In addition they may adapt by changing their morphology, forming biofilms, fruiting bodies or spores, filaments, Viable But Not Culturable (VBNC) cells or moving away from stress compounds via chemotaxis. Changes in gene expression constitute the main component...
A Tight Embrace
This book provides various examples showing how Europe and Africa can be conceptualized and researched as a single macro-area connected by interrelated, global and multilevel dynamics. What types of relations characterize Europe and Africa today? The nature of the connections is neither clear nor unilinear: rather, they appear dialectical, multifaceted and pointing in different directions. This edited book explores narratives, contemporary dynamics and historical legacies demonstrating the long-standing relations between the continents, suggesting that the entangled Euro-African relations in multiple fields should be intended as a permanent condition for any analyses. The authors provide var...
Proteomics of Microbial Human Pathogens
According to the World Health Organization (WHO), in 2012 infectious diseases and related conditions account for more than 70% of premature deaths across 22 African countries and estimated 450 000 people worldwide developed multi-drug resistant tuberculosis. This alarming situation, of great public health concern, calls for the urgent development of novel and efficient responding strategies. The employment of important research platforms, such as genomics and proteomics, has contributed significant insight into the mechanisms underlying microbial infection and microbe-host interaction. In this Frontiers Research Topic, we aim to produce a timely and pertinent discussion regarding the current...
