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Integration of Pharmaceutical Discovery and Development
In the late 1980s, it became painfully evident to the pharmaceutical industry that the old paradigm of drug discovery, which involved highly segmented drug - sign and development activities, would not produce an acceptable success rate in the future. Therefore, in the early 1990s a paradigm shift occurred in which drug design and development activities became more highly integrated. This new str- egy required medicinal chemists to design drug candidates with structural f- tures that optimized pharmacological (e. g. , high affinity and specificity for the target receptor), pharmaceutical (e. g. , solubility and chemical stability), bioph- maceutical (e. g. , cell membrane permeability), and m...
Journal of Engineering, Management and Operations Vol. I
Prof. Dr.-Ing. Prof. e. h. Wilhelm Bauer ist geschäftsführender Institutsleiter des Fraunhofer-Instituts für Arbeitswirtschaft und Organisation IAO und Vorsitzender des Fraunhofer-Verbunds Innovationsforschung. Univ.-Prof. Dr.-Ing. Dr. h.c. Dipl.-Wirtsch.-Ing. Wilfried Sihn ist seit 2004 Professor an der TU Wien und seit 2008 Geschäftsführer der Fraunhofer Austria Research GmbH. Prof. Dr.-Ing. Peter Ohlhausen ist am Fraunhofer-Instituts für Arbeitswirtschaft und Organisation IAO für den Bereich Forschungskoordination zuständig und Professor an der ESB.
History of Photography
The fourth volume in a history of photography, this is a bibliography of books on the subject.
Machine Vision
The book offers a thorough introduction to machine vision. It is organized in two parts. The first part covers the image acquisition, which is the crucial component of most automated visual inspection systems. All important methods are described in great detail and are presented with a reasoned structure. The second part deals with the modeling and processing of image signals and pays particular regard to methods, which are relevant for automated visual inspection.
The Geology and Tectonics of the Jabal Akhdar and Saih Hatat Domes, Oman Mountains
The geology of the Oman Mountains, including the Jabal Akhdar and Saih Hatat domes, is extraordinarily well-exposed and diverse, spanning a geological record of more than 800 Ma. The area is blessed with first-class outcrops and is well known in the geological community for its ophiolite. The Oman Mountains have much more to offer; including, Neoproterozoic diamictites (‘Snowball Earth’), fossil-rich Permo–Mesozoic carbonates and metamorphic rocks. The arid climate and deep incision of wadis allow for nearly complete rock exposure which can be investigated in all three dimensions. The diverse geology is also responsible for the breathtaking landscape. New roads and the nature of the friendly Omani people make fieldwork unforgettable. This Memoir provides a thorough state-of-the-art overview of the geology and tectonics of the Southeastern Oman Mountains, and is accompanied by an oversized geological map.
Recent Research on Sedimentology, Stratigraphy, Paleontology, Tectonics, Geochemistry, Volcanology and Petroleum Geology
This edited book is based on the accepted papers for presentation at the 1st MedGU Annual Meeting, Istanbul 2021. With four parts spanning a large spectrum of geological, geochemical, geophysical and petroleum topics, this book presents a series of newest research studies that are nowadays relevant to Middle East, Mediterranean region, and Africa. The book covers various topics from the fields of (1) sedimentology, stratigraphy, paleontology, (2) geochemistry, mineralogy, petrology, volcanology, (3) structural geology, tectonics, geodynamics, and (4) petroleum and energy engineering, and petroleum geology. The content of these papers provides new scientific knowledge for further understanding new case studies and approaches in these various topics.
Thinking Utopia
After the breakdown of socialist and communist systems in the East, it had become fashionable to declare the so-called "end of utopia" ("end of history," "end of narratives"). The authors of this volume do not share this view but think that it is time to rehabilitate utopian thought. The political concept of Utopia that has given its name to these transcendental projections onto the world has been too narrow to describe and analyze the moving forces of the mind perceiving human existence beyond reality. By broadening the perspectives of utopian studies, these essays enable the reader to reconstruct scholarly paradigms and strategies of utopian, complex and holistic thinking in modern cosmology, philosophy, sociology, in literary, historical and political sciences, and to compare traditions and ways of Western utopian thought to the practice in the East.
True or False? The most, exciting 666 myths of our life
If you want to expand your knowledge and be ahead of your fellow human beings, you should read the book. It clears up old folk wisdom and brings light into the darkness of advice that is over 100 years old. Science brings new knowledge every day and exposes old sayings and advice as half-truths or even lies. With the knowledge from the book you are definitely ahead of your fellow human beings.sen wants to expand and be ahead of your fellow human beings, the book should read It clears up old folk wisdom and brings light into the darkness of advice that is over 100 years old. Science brings new insights every day and exposes old sayings and advice as half-truths or even lies. With the knowledge from the book you are definitely ahead of your fellow men.
