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Integration of Pharmaceutical Discovery and Development
In the late 1980s, it became painfully evident to the pharmaceutical industry that the old paradigm of drug discovery, which involved highly segmented drug - sign and development activities, would not produce an acceptable success rate in the future. Therefore, in the early 1990s a paradigm shift occurred in which drug design and development activities became more highly integrated. This new str- egy required medicinal chemists to design drug candidates with structural f- tures that optimized pharmacological (e. g. , high affinity and specificity for the target receptor), pharmaceutical (e. g. , solubility and chemical stability), bioph- maceutical (e. g. , cell membrane permeability), and m...
History of Photography
The fourth volume in a history of photography, this is a bibliography of books on the subject.
Machine Vision
The book offers a thorough introduction to machine vision. It is organized in two parts. The first part covers the image acquisition, which is the crucial component of most automated visual inspection systems. All important methods are described in great detail and are presented with a reasoned structure. The second part deals with the modeling and processing of image signals and pays particular regard to methods, which are relevant for automated visual inspection.
Thinking Utopia
After the breakdown of socialist and communist systems in the East, it had become fashionable to declare the so-called "end of utopia" ("end of history," "end of narratives"). The authors of this volume do not share this view but think that it is time to rehabilitate utopian thought. The political concept of Utopia that has given its name to these transcendental projections onto the world has been too narrow to describe and analyze the moving forces of the mind perceiving human existence beyond reality. By broadening the perspectives of utopian studies, these essays enable the reader to reconstruct scholarly paradigms and strategies of utopian, complex and holistic thinking in modern cosmology, philosophy, sociology, in literary, historical and political sciences, and to compare traditions and ways of Western utopian thought to the practice in the East.
Human Starpilot
In 2130, Earth ecology is failing fast. Its inhabitants are dying and the governments are hard pressed to contain the disaster. So when an Alien Federation suddenly contacts Earth and offers assistance, everyone jumps on it. There are further surprises: those aliens prove, once their DNA analysed, to be distant cousin from us. The Federation will provide to Earth advanced technology and support against the climate change with a single condition: To trade among stars, they need pilots capable of managing hyperspace jumps and only rare humans have what it takes to survive the training and become one. To receive support, Earth has to find and provide starpilots to take its share of the load. After a careful selection, six are chosen to fly to the far away planet Adheek. There, they will try to learn their new trade. If they fail, Earth will collapse. If they succeed, it may have a chance. But no one has prepared them to what they will face to gain that chance. This debut novel was inspired by the classic “Have space suit, will travel” from R Heinlein and by the science-fiction work from LE Modesitt. It is a tale of adventure in a far land, of going beyond one’s own limits.
Antarctic Basalt
“By 1st February the unloading had been completed, and when the ice anchors had been recovered the ship drew slowly away from the ice edge. The dull weather could not suppress the thrill that pulsed through me – this was the real start of my adventure. Up till then I could at any time have turned back. It might have been embarrassing, inconvenient, or expensive, but it had been possible. Now there would be no more direct contact with the outside world until the ship returned for another brief week or so in a year’s time. There was no air link, established or even planned. Was any other workplace in the world as isolated? Even in the Antarctic, did any other base have so fleeting a relief? Together with my companions I was irrevocably committed.” Lewis Juckes describes the many new experiences that lay ahead over the next two years, first while living in huts buried deep within the snow and then in the field with dog teams for transport and tents for accommodation. Thrills and rare sights were there, as well as scares and dangers – and tragedy within the close-knit group. This was Antarctica in the mid-1960s.
Neoplastic Gastrointestinal Pathology
" Approximately 20 million gastrointestinal tract biopsies are performed each year in the United States. While many of these are straightforward, some are histologically subtle or involve a complex differential diagnosis. This concise visual guide to the full range of neoplastic gastrointestinal specimens provides the practicing pathologist or trainee with a clear analysis and diagnosis of both common and potentially misleading variants of disease. The authors cover the full tubular GI tract with over 600 high-quality images and a concise description of the key features of each entity: definitions and terminology, gross and morphologic features, differential diagnoses, useful ancillary tests, staging and grading parameters, and special clinical considerations. Images depict differential diagnosis features, frequently seen variants that can potentially lead to misclassification or misdiagnosis, and correlated molecular and immunologic techniques. "
ANIMAE
Romanticism, the brooding and intensely personal eighteenth-century art and literary movement, takes on a new lease of life in this carefully curated collection of interviews with contemporary artists from around the world. Informed by the writings of the renowned psychoanalyst James Hillman, Romanticism is reconsidered from a twenty-first-century perspective. Moving past a purely formal presentation of the artists’ work, this text strives to uncover the deeper meaning and more pressing issues present in the artworks. All connected by a similar romantic vein, Emma Coccioli explores each artist’s individual practice through a series of carefully selected questions. For Coccioli, discussio...
Geodynamic Evolution of East Antarctica
Geological correlations of East Antarctica with adjoining continents have been puzzling geologists ever since the concept of a Gondwana supercontinent surfaced. Despite the paucity of outcrops because of ice cover, difficulty of access and extreme weather, the past 50 years of Japanese Antarctic Research Expeditions (JARE) has successfully revealed vital elements of the geology of East Antarctica. This volume presents reviews and new research from localities across East Antarctica, especially from Dronning Maud Land to Enderby Land, where the geological record preserves a history that spans the Archaean and Proterozoic. The reviews include extensive bibliographies of results obtained by geologists who participated in the JARE. Comprehensive geological, petrological and geochemical studies, form a platform for future research on the formation and dispersion of Rodinia in the Mesoproterozoic and subsequent assembly of Gondwana in the Neoproterozoic to Early Palaeozoic.
