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Feature interview with Dr. William C. CHO - “Clarivate 2023 Highly Cited Researcher”
This insightful interview article covers the Journal of Cancer Metastasis and Treatment’s special interview with Dr. William C. Cho, focusing on his career trajectory, research focus, and ambitious goals for the next five years in cancer research. Dr. Cho, recognized as a Highly Cited Researcher in 2023 by Clarivate, has a wide research spectrum, including cancer biomarkers, non-coding RNA, genomics, and bioinformatics. In the interview, he elaborates on how advancements in these areas contribute to cancer treatment, emphasizing their potential impact on personalized medicine and therapeutic strategies. Dr. Cho shares experiences, underscores the importance of interdisciplinary collaborations, and highlights upcoming trends in cancer research. The interview may offer some guidance and advice to early-career researchers, encouraging them to find their passion, broaden their horizons, and make meaningful contributions to the field of cancer research.
Cancer-associated fibroblasts (CAFs) based model reveals potential for predicting bladder cancer patients’ prognoses and immunotherapy responses
Aim: The purpose of this study is to enhance the understanding of bladder cancer and the role of cancer-associated fibroblasts (CAFs) in its progression. We aim to identify CAF-specific biomarkers and develop a prognostic prediction model based on CAFs, thereby contributing to the advancement of treatment strategies and the identification of prognostic and predictive biomarkers for bladder cancer. Method: We employed single-cell RNA sequencing to detect biomarkers for CAFs in bladder cancer cells. Bladder cancer cohorts were categorized into low- and high-CAF groups using the ssGSEA algorithm. The study also explored the association between CAF-related scores, immune-related cells, and immun...
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