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Life as It Is
"This book is an enjoyable and thought-provoking 'My Dinner With Bill Loomis'. He shows how respect for human life means acknowledging its ecological and evolutionary contexts. Molecular biology, he writes, is like Prometheus, giving us incredible tools for good or evil—and it's time that we grow up."—Scott F. Gilbert, Howard A. Schneiderman Professor of Biology, Swarthmore College "A wonderful journey through the very basis of life and how we live."—Lewis Wolpert, Professor of Biology as Applied to Medicine, University College, London "Advances in biology increasingly impinge on our everyday lives, challenging us with new interventions and ideas of what it means to be human. In this book, the distinguished scientist Bill Loomis takes us effortlessly through the biology we need to understand to come to our own opinions about these issues of great importance to each of us and to society as a whole."—Paul Nurse, President of Rockefeller University, Winner of the Nobel Prize in Physiology and Medicine
The Development Of Dictyostelium Discoideum
The Development of Dictyostelium discoideum consists of 11 chapters representing the 11 major aspects at which continuous progress are made in the study of Dictyostelium discoideum. This book begins with the discovery, classification, ecology, and development of Dictyostelium discoideum. It then outlines the advances in genetic manipulation and mutant isolation of the organism. Much of the advances in cell biology have been related to a better understanding of the composition and function of the cell membrane. Hence, analyses of Dictyostelium plasma membranes are collated. This reference material also describes the role of chemoattractants in organizing cell movements and the intracellular e...
Dictyostelium Discoideum
Dictyostelium Discoideum: A Developmental System presents D. discoideum as a model eukaryotic system to study a variety of developmental problems. The book describes the life cycle of the organism D. discoideum which exists in nature as a soil amoeba in forest detritus. The nuclei of D. discoideum contain DNA, RNA, and proteins which have properties similar to those of histones present in calf thymus nuclei. The unique sequences of the genome of the organism code for the gene products synthesize during its growth and development. One approach in genetic analyses to understanding the developmental processes of the organism is to isolate a large number of morphological mutants. The isolation p...
Dictyostelium Genomics
Dictyostelium discoideum is a model eukaryotic organism for basic biomedical research in cell and developmental biology and for the functional analysis of sequenced genes. The organism has unique advantages for studying fundamental cellular processes such as cytokinesis, motility, phagocytosis, chemotaxis, signal transduction, cell sorting, pattern formation, and cell-type determination. This book, written to coincide with the publication of the genome sequence of Dictyostelium, introduces the post-genomic era and focuses on the important aspects of Dictyostelium genomics. Leading experts in the field have contributed chapters on genomic mapping and sequencing, databases, multigene families, regulation of gene expression, signal transduction, the microfilament system, the GTPase superfamily, the kinome, glycosyltransferase genomics, and whole-genome functional analysis.
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Genetic Regulation of Development
Uncovering the functions of genes is the key to understanding the rules that govern the development, similarities, and differences among organisms and the way in which traits are passed on from one generation to another. The central theme of this volume is genetic analysis at both the molecular and phenotypic levels, emphasizing the ``simpler organisms,'' e.g., yeast. Contributions represent the latest findings in yeast research and explore their relevance and importance in developmental biology as a whole. Coverage includes an examination on how specific regulatory proteins interact with genes that determine segment specification; differential adhesion and growth in Drosophilis compartments; differentiation in unicellular organisms such as Neurospora, Aspergillus, Chlamydomonas, and others; gene responses to environmental clues; the application of monoclonal antibodies and microscopy in the field, and directions for future research.
