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Randomization in Clinical Trials
Praise for the First Edition “All medical statisticians involved in clinical trials should read this book...” - Controlled Clinical Trials Featuring a unique combination of the applied aspects of randomization in clinical trials with a nonparametric approach to inference, Randomization in Clinical Trials: Theory and Practice, Second Edition is the go-to guide for biostatisticians and pharmaceutical industry statisticians. Randomization in Clinical Trials: Theory and Practice, Second Edition features: Discussions on current philosophies, controversies, and new developments in the increasingly important role of randomization techniques in clinical trials A new chapter on covariate-adaptive...
The Theory of Response-Adaptive Randomization in Clinical Trials
Presents a firm mathematical basis for the use of response-adaptive randomization procedures in practice The Theory of Response-Adaptive Randomization in Clinical Trials is the result of the authors' ten-year collaboration as well as their collaborations with other researchers in investigating the important questions regarding response-adaptive randomization in a rigorous mathematical framework. Response-adaptive allocation has a long history in biostatistics literature; however, largely due to the disastrous ECMO trial in the early 1980s, there is a general reluctance to use these procedures. This timely book represents a mathematically rigorous subdiscipline of experimental design involvin...
Randomization in Clinical Trials
A unique overview that melds the concepts of conditionalprobability and stochastic processes into real-lifeapplications The role of randomization techniques in clinical trials has becomeincreasingly important. This comprehensive guide combines both theapplied aspects of randomization in clinical trials with aprobabilistic treatment of properties of randomization. Taking anunabashedly non-Bayesian and nonparametric approach to inference,the book focuses on the linear rank test under a randomizationmodel, with added discussion on likelihood-based inference as itrelates to sufficiency and ancillarity. Developments in stochasticprocesses and applied probability are also given where appropriate.I...
Strength in Numbers: The Rising of Academic Statistics Departments in the U. S.
Statistical science as organized in formal academic departments is relatively new. With a few exceptions, most Statistics and Biostatistics departments have been created within the past 60 years. This book consists of a set of memoirs, one for each department in the U.S. created by the mid-1960s. The memoirs describe key aspects of the department’s history -- its founding, its growth, key people in its development, success stories (such as major research accomplishments) and the occasional failure story, PhD graduates who have had a significant impact, its impact on statistical education, and a summary of where the department stands today and its vision for the future. Read here all about how departments such as at Berkeley, Chicago, Harvard, and Stanford started and how they got to where they are today. The book should also be of interests to scholars in the field of disciplinary history.
Fundamentals of Crystal Growth I
The intrinsic properties of a solid, i. e. , the properties that result from its specific structure, can be largely modified by crystallographic and chem ical defects. The formation of these defects is governed by the heat and mass transfer conditions which prevail on and near a crystal-nutrient in terface during crystallization. Hence, both the growth of highly perfect crystals and the preparation of samples having predetermined defect-induced (extrinsic) properties require a thorough understanding of the reaction and transport mechanisms that govern crystallization from vapors, solutions and melts. Crystal growth, as a science, is therefore mostly concerned with the chemistry and physics o...
New World Monkeys
"This book is a broad synthesis of new world monkey evolution, integrating their unique evolutionary story into the bigger picture of primate evolution and Amazon biodiversity. Capsule For more than 30 million years, New World monkeys have inhabited the forests of South and Central America. Whether these primates originally came from Africa by rafting across the Atlantic or crossing overland from North America, they soon flourished. This book tells the story of these New World monkeys. Integrating data from fossil and living animals, it explores the evolution of the three major New World monkey lineages as well as how they fit into the broader story of primate evolution and Amazon biodiversi...
Advances in Multivariate Statistical Methods
This volume contains a collection of research articles on multivariate statistical methods, encompassing both theoretical advances and emerging applications in a variety of scientific disciplines. It serves as a tribute to Professor S N Roy, an eminent statistician who has made seminal contributions to the area of multivariate statistical methods, on his birth centenary. In the area of emerging applications, the topics include bioinformatics, categorical data and clinical trials, econometrics, longitudinal data analysis, microarray data analysis, sample surveys, statistical process control, etc. Researchers, professionals and advanced graduates will find the book an essential resource for modern developments in theory as well as for innovative and emerging important applications in the area of multivariate statistical methods.
Shot in Alabama
A sumptuously illustrated history of photography as practiced in the state from 1839 to 1941 offering a unique account of the birth and development of a significant documentary and artistic medium
Optimized Response-Adaptive Clinical Trials
Two-armed response-adaptive clinical trials are modelled as Markov decision problems to pursue two overriding objectives: Firstly, to identify the superior treatment at the end of the trial and, secondly, to keep the number of patients receiving the inferior treatment small. Such clinical trial designs are very important, especially for rare diseases. Thomas Ondra presents the main solution techniques for Markov decision problems and provides a detailed description how to obtain optimal allocation sequences.
Statistical Methods in Healthcare
Statistical Methods in Healthcare In recent years the number of innovative medicinal products and devices submitted and approved by regulatory bodies has declined dramatically. The medical product development process is no longer able to keep pace with increasing technologies, science and innovations and the goal is to develop new scientific and technical tools and to make product development processes more efficient and effective. Statistical Methods in Healthcare focuses on the application of statistical methodologies to evaluate promising alternatives and to optimize the performance and demonstrate the effectiveness of those that warrant pursuit is critical to success. Statistical methods...
