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GEOGRAFIA EM FOCO: teorias e práticas
O livro Geografia em Foco: Teorias e Práticas traz uma coletânea de artigos científicos com reflexões teóricas e, também, estudos de casos e experiências pedagógicas sobre uma grande diversidade de temas dentro da ciência geográfica. Esta obra surge a partir da necessidade de oportunizar que o conhecimento elaborado por diversos pesquisadores do Brasil possa alcançar não somente a comunidade acadêmica, mas também todos aqueles que se interessem pelas discussões que permeiam o espaço geográfico. Assim, por meio da variabilidade temática e metodológica da Geografia esta obra aponta perspectivas no âmbito educacional, econômico, ambiental, cultural e social.
Landscapes and Landforms of Brazil
This book presents Brazil as a country of continental dimensions. Its territory has a large variety of rock types, geological structures and climates. The country has a large variety of landscapes, such as the humid plains of the Amazon River, the dry plateaus of the semi-arid region or the subtropical mountains of the southern region. On the coast, some plateaus and mountains, like the Serra do Mar Mountain range, formed a significant barrier front to access the hinterland of Brazil. On the other side of these coastal plateaus and mountains, there is a large collection of other plateaus, mountains, plains and depressions little altered by human interference. Thus, Brazil has a unique variety of different landscapes and extraordinary geomorphological sites. The book invites readers to learn more about the beautiful Brazilian landscapes, their complexity and vastness.
Quantal Density Functional Theory
Density functional theory is an important and widely used tool in many-body physics that has found applications in atomic, molecular, solid-state and nuclear physics. It is used principally to determine the electronic structure of these complex systems. Sahni has developed a new approach, termed quantal density functional theory, which simplifies the process of solving the computational problem and at the same time, gives insight into the underlying quantum mechanics. Further, the book describes Schrödinger theory from the new perspective of fields and quantal sources. It also explains the physics underlying the functionals and functional derivatives of traditional DFT
Protein-Ligand Interactions and Drug Design
This detailed book collects modern and established computer-based methods aimed at addressing the drug discovery challenge from disparate perspectives by exploiting information on ligand-protein recognition. Beginning with methods that allow for the exploration of specific areas of chemical space and the designing of virtual libraries, the volume continues with sections on methods based on docking, quantitative models, and molecular dynamics simulations, which are employed for ligand discovery or development, as well as methods exploiting an ensemble of protein structures for the identification of potential protein targets. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Protein-Ligand Interactions and Drug Design provides detailed practical procedures of solid computer-aided drug design methodologies employed to rationalize and optimize protein-ligand interactions, for experienced researchers and novices alike.
Cellulose Derivatives
This book summarizes recent progress in cellulose chemistry. The last 10 years have witnessed important developments, because sustainability is a major concern. Biodegradable cellulose derivatives, in particular esters and ethers, are employed on a large scale. The recent developments in cellulose chemistry include unconventional methods for the synthesis of derivatives, introduction of novel solvents, e.g. ionic liquids, novel approaches to regioselective derivatization of cellulose, preparation of nano-particles and nano-composites for specific applications. These new developments are discussed comprehensively. This book is aimed at researchers and professionals working on cellulose and its derivatives. It fills an important gap in teaching, because most organic chemistry textbooks concentrate on the relatively simple chemistry of mono- and disaccharides. The chemistry and, more importantly, the applications of cellulose are only concisely mentioned.
Cancer Epigenetics for Precision Medicine
This volume discusses certain epigenetic changes recognized in early carcinogenic lesions and different tumors, as well as factors that alter the epigenome and epigenetic profile such as diet, alcohol, immunity, circadian rhythm, and more. The chapters in this book further delve into this field and cover topics such as epigenome-based precision medicine in lung cancer; interplay between genetic and epigenetic changes in breast cancer subtypes; genetic regulation of PDCD1 gene in cancer immunology; and pyrosequencing methylation analysis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and authoritative, Cancer Epigenetics for Precision Medicine: Methods and Protocols is a valuable resource to help researchers and scientists identify these specific biomarkers and work towards the prevention, diagnosis, and prognosis of different cancers in the future.
Architecture and Geometry in the Age of the Baroque
The age of the baroque -- a time of great strides in science and mathematics -- also saw the construction of some of the world's most magnificent buildings. In this book, George L. Hersey explores the interrelations of the two developments, explaining how the advancements of geometry and the abstractions of mathematicians were made concrete in the architecture of the day. Copyright © Libri GmbH. All rights reserved.
Computational Methods for GPCR Drug Discovery
This volume looks at modern computational strategies and techniques used in GPCR drug discovery including structure and ligand-based approaches and cheminformatics. The chapters in this book describe how these approaches can be applied to address key drug discovery issues, such as receptor structure modelling, function and dynamics, prediction of protein-water-ligand interactions and binding kinetics, free energy of binding, interconversion between agonists and antagonists, deorphanization of GPCRs, and the discovery of biased and allosteric modulators. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary software and tools, step-by-step, readily reproducible modelling protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and unique,Computational Methods for GPCR Drug Discovery is a valuable resource for structural and molecular biologists, computational and medicinal chemists, pharmacologists, and drug designers.
Tree Biotechnology
Forest trees cover 30% of the earth's land surface, providing renewable fuel, wood, timber, shelter, fruits, leaves, bark, roots, and are source of medicinal products in addition to benefits such as carbon sequestration, water shed protection, and habitat for 1/3 of terrestrial species. However, the genetic analysis and breeding of trees has lagged behind that of crop plants. Therefore, systematic conservation, sustainable improvement and pragmatic utilization of trees are global priorities. This book provides comprehensive and up to date information about tree characterization, biological understanding, and improvement through biotechnological and molecular tools.
Science in the Spanish and Portuguese Empires, 1500–1800
This collection of essays is the first book published in English to provide a thorough survey of the practices of science in the Spanish and Portuguese empires from 1500 to 1800. Authored by an interdisciplinary team of specialists from the United States, Latin America, and Europe, the book consists of fifteen original essays, as well as an introduction and an afterword by renowned scholars in the field. The topics discussed include navigation, exploration, cartography, natural sciences, technology, and medicine. This volume is aimed at both specialists and non-specialists, and is designed to be useful for teaching. It will be a major resource for anyone interested in colonial Latin America.
