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Ticlopidine, Platelets and Vascular Disease
Blood platelets lack a nucleus. As a result their life span is short and they cannot reproduce themselves. Platelets share these qualities with the red blood cell. Plate lets and red blood cells, nevertheless, serve vital roles in the body. One major function of the platelet is its capacity to aggregate and thereby initiate intravas cular coagulation which often underlies such major diseases as myocardial infarc tion, cerebral infarction, and pulmonary embolism. For this reason in recent years, medical attention has been directed to drugs that inhibit platelet aggregation. Aspirin was the first drug to be proven effective in this area. Since then other drugs that share aspirin's fundamental biochemical action, inhibition of platelet cyclooxygenase, have also been studied. Very recently, ticlopidine, the first of what promises to be a new class of drugs inhibiting platelet aggregation and coagulation via an entirely different biochemical mechanism, has been exten sively studied and clinically shown to be as effective or more effective than aspirin in the prevention of ischemic cardiovascular and cerebrovascular disease.
Report of the Panel on Stroke, Trauma, Regeneration, and Neoplasms to the National Advisory Neurological and Communicative Disorders and Stroke Council
This is the story of the savage, tormented foundling Heathcliff, who falls wildly in love with Catherine Earnshaw, the daughter of his benefactor, and the violence and misery that result from their thwarted longing for each other. A book of great power and strength, it is filled with the raw beauty of the moors and an uncanny understanding of the terrible truths about men and women. It is an understanding made even more extraordinary by the fact that it came from the heart of a woman who lived most of her brief life in the remote wildness of the moors.
Current Catalog
First multi-year cumulation covers six years: 1965-70.
