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Textbook of Stroke Medicine
Fully revised throughout, the new edition of this concise textbook is aimed at doctors preparing to specialize in stroke care.
Textbook of Stroke Medicine
Fully revised, this third edition is a concise and practice-orientated guide to the fast-moving and expanding field of stroke medicine.
Ischemic Blood Flow in the Brain
Because stroke is essentially a disease of the vessels and blood flow, the most fundamental aspects of ischemic blood flow in the brain are under investigation by researchers. Their work was the focus of the sixth in the series of Keio University International Symposia for Life Sciences and Medicine, held in Tokyo in 1999. Selected here are 55 papers from the symposium, covering the buffy coat (glycocalyx) of endothelial cells, the blood-brain barrier and permeability, gene expression, vascular reactivity, dysregulation, inflammatory deterioration, cortical spreading depression, edema, microvascular derangement, and pathology, in ten major sections. The book includes the thought-provoking discussions that followed the presentations, thus providing an invaluable source of up-to-date information not only for researchers investigating microcirculation but also for clinicians implementing the most effective treatment for stroke patients.
PET and SPECT of Neurobiological Systems
This book, now in a fully updated second edition, is a comprehensive and up-to-date guide to the use of PET and SPECT for the imaging of neurobiological systems. Diverse aspects of neurotransmission in the brain are discussed, such as visualization and quantification of neuroreceptors, neuroinflammatory markers, transporters, and enzymes as well as neurotransmitter synthesis, β-amyloid deposition, cerebral blood flow, and the metabolic rate of glucose. The latest results in probe development are also detailed. A wide range of systems not addressed in the first edition are covered, reflecting the advances made in recent years. The book combines the expertise of authors internationally renowned for their dedication to the development of novel probes and techniques for the investigation of neurobiological systems. Most chapters are written jointly by radiochemists and nuclear medicine specialists to ensure a multidisciplinary approach. This state of the art compendium will be valuable to all with an interest in clinical and preclinical neuroscience. Companion volumes on the use of PET and SPECT in neurology and psychiatry complete a trilogy.
The Complicity of Friends
One of Victorian England’s most famous philosophers harbored a secret: Herbert Spencer suffered from an illness so laden with stigma that he feared its revelation would ruin him. He therefore went to extraordinary lengths to hide his malady from the public. Exceptionally, he drew two of his closest friends—the novelist George Eliot and her partner, G. H. Lewes—into his secret. Years later, he also shared it with a remarkable neurologist, John Hughlings-Jackson, better placed than anyone else in England to understand his illness. Spencer insisted that all three support him without betraying his condition to others—and two of them did so. But George Eliot, still smarting from Spencerâ€...
Handbook of Autobiography / Autofiction
Autobiographical writings have been a major cultural genre from antiquity to the present time. General questions of the literary as, e.g., the relation between literature and reality, truth and fiction, the dependency of author, narrator, and figure, or issues of individual and cultural styles etc., can be studied preeminently in the autobiographical genre. Yet, the tradition of life-writing has, in the course of literary history, developed manifold types and forms. Especially in the globalized age, where the media and other technological / cultural factors contribute to a rapid transformation of lifestyles, autobiographical writing has maintained, even enhanced, its popularity and importanc...
Stories of Stroke
Stroke is one of the most important and most feared conditions known to man. The threat of stroke is important to all people. What could be more devastating than to lose the ability to speak, move a limb, stand, talk, see, read, feel write or even think? This book brings together ideas, events and advances – the stories – before and during the 20th Century through the accounts of global experts in the field, many of them having been first-hand witnesses to progress. Focusing on selected stories of stroke, this book offers a readable summary of the most dramatic and extensive changes in knowledge about stroke and in caring for stroke patients. Of interest to anyone interested in neurosciences and for physicians caring for stroke patients, this book informs on moving forward, by looking to how we got to where we are.
Pioneering Stem Cell/Gene Therapy Trials
The first unequivocal success for Gene Therapy was reported in April 2000 for X-SCID patients. Pioneering stem cell/gene therapy clinical trials are the focus of this book. Therapy successes such as the X-SCID trial and improved ADA-SCID ones are presented together with pioneering angio/vasculogenic clinical trials mediated either by transient gene therapy or emerging autologous stem cell transplantation. Highlights also include 1) promises of the breakthrough combination of stem cell- and transient gene-therapy, 2) gene therapy trials for neurodegenerative disease on non-human primates where long-term gene therapy might involve brain stem cells, and 3) the first clinical trial with non-invasive monitoring of therapeutic gene expression as a prospective conclusion.
Acute Stroke
As the third leading cause of death in the United States, stroke accounts for one in every fifteen deaths and is the major cause of disability in the country. Compiled by a renowned editorial team, this reference bridges the gap between basic science and patient care protocols, and collects 43 expertly written chapters that range from laboratory-ba
fMRI
Functional MRI (fMRI) and the basic method of BOLD imaging were introduced in 1993 by Seiji Ogawa. From very basic experiments, fMRI has evolved into a clinical application for daily routine brain imaging. There have been various improvements in both the imaging technique as such as well as in the statistical analysis. In this volume, experts in the field share their knowledge and point out possible technical barriers and problems explaining how to solve them. Starting from the very basics on the origin of the BOLD signal, the book covers technical issues, anatomical landmarks, presurgical applications, and special issues in various clinical fields. Other modalities for brain mapping such as PET, TMS, and MEG are also compared with fMRI. This book is intended to give a state-of-the-art overview and to serve as a reference and guide for clinical applications of fMRI.
