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TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades
Since the first TRP ion channel was discovered in Drosophila melanogaster in 1989, the progress made in this area of signaling research has yielded findings that offer the potential to dramatically impact human health and wellness. Involved in gateway activity for all five of our senses, TRP channels have been shown to respond to a wide range of st
Statistical Techniques for Neuroscientists
Statistical Techniques for Neuroscientists introduces new and useful methods for data analysis involving simultaneous recording of neuron or large cluster (brain region) neuron activity. The statistical estimation and tests of hypotheses are based on the likelihood principle derived from stationary point processes and time series. Algorithms and software development are given in each chapter to reproduce the computer simulated results described therein. The book examines current statistical methods for solving emerging problems in neuroscience. These methods have been applied to data involving multichannel neural spike train, spike sorting, blind source separation, functional and effective n...
Translational Research in Traumatic Brain Injury
Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the developme
Neurobiology of TRP Channels
During the last two decades, there has been an explosion of research pertaining to the molecular mechanisms that allow for organisms to detect different stimuli that is an essential feature for their survival. Among these mechanisms, living beings need to be able to respond to different temperatures as well as chemical and physical stimuli. Thermally activated ion channels were proposed to be present in sensory neurons in the 1980s, but it was not until 1997 that a heat- and capsaicin- activated ion channel, TRPV1, was cloned and its function described in detail. This groundbreaking discovery led to the identification and characterization of several more proteins of the family of Transient R...
Autism
Autism: The Movement Sensing Perspective is the result of a collaborative effort by parents, therapists, clinicians, and researchers from all disciplines in science including physics, engineering, and applied mathematics. This book poses questions regarding the current conceptualization and approach to the study of autism, providing an alternative unifying data-driven framework grounded in physiological factors. This book reaches beyond subjective descriptions of autistic phenomena and embraces a new era of objective measurements, analyses, and statistical inferences. The authors harness activities from the nervous systems across the brain and body (often in tandem), and introduce a platform for the comprehensive personalized phenotyping of individuals with autism. The impact of this approach is discussed to advance the development of tailored treatments options, enhance the ability to longitudinally track symptomatology, and to fundamentally empower affected individuals and their families. This book encompasses a new era for autism research and treatments, and our continuous effort to collectively empower and embrace the autistic community.
OCT Angiography
The definitive guide on state-of-the-art OCT angiography from leading worldwide experts OCT Angiography by David R. Chow and a cadre of renowned authors is an authoritative, richly illustrated guide on a groundbreaking new ophthalmic imaging technique. Optical coherence tomography angiography is revolutionizing ophthalmologic diagnosis and management of retinal disease. The technology is transforming the ocular disease diagnostic paradigm - from the retina to the choroid - enabling precision-tailored patient management. Noninvasive and more sophisticated than fluorescein angiography, OCTA obviates the need for dye and yields an unprecedented level of detail. The layered visualization of the ...
Trapping Highly Charged Ions
This book provides and elementary introduction to the field of trapping highly charged ions. The first group of chapters is intended to describe the various sorts of highly charged ion traps: EBIT, EBIS, ECR, Storage Rings and various speciality traps. The authors focus on their own ion trap facilities in order to teach by example. The chapters range in scope from comprehensive reviews to brief introductions. The second group of chapters is intended to give a flavour of the various sorts of scientific research which are presently being carried out with traps for highly charged ions. These chapters not only inform, but also stimulate newcomers to think up fresh ideas. The articles in this second group generally fall into one of three broad categories: atomic structure experiments, ion-surface interactions and precision mass spectrometry. The third group of chapters is intended to deal with theory and spectroscopic analysis. It provides some of the background material necessary to make sense of observed phenomenology, to allow detailed explanation of experimental data, and to sensibly plan further experimentation. An appendix provides a complete keyword-annotated bibliography of pa
Object-Based Image Analysis
This book brings together a collection of invited interdisciplinary persp- tives on the recent topic of Object-based Image Analysis (OBIA). Its c- st tent is based on select papers from the 1 OBIA International Conference held in Salzburg in July 2006, and is enriched by several invited chapters. All submissions have passed through a blind peer-review process resulting in what we believe is a timely volume of the highest scientific, theoretical and technical standards. The concept of OBIA first gained widespread interest within the GIScience (Geographic Information Science) community circa 2000, with the advent of the first commercial software for what was then termed ‘obje- oriented image analysis’. However, it is widely agreed that OBIA builds on older segmentation, edge-detection and classification concepts that have been used in remote sensing image analysis for several decades. Nevert- less, its emergence has provided a new critical bridge to spatial concepts applied in multiscale landscape analysis, Geographic Information Systems (GIS) and the synergy between image-objects and their radiometric char- teristics and analyses in Earth Observation data (EO).
