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Triple-negative Breast Cancer
Triple-negative breast cancer (TNBC) represents a challenge clinically due to the lack of actionable targets coupled with an aggressive disease course and a worse prognosis compared to other breast cancer subtypes. This book covers aspects of TNBC ranging from epidemiology, biology, molecular classification, to currently available and potentially new therapeutic options for TNBC. This book contains a range of recommended resources, including recent reviews, schematic illustrations, and information for patients with TNBC. Individuals including researchers and educators, practitioners, pharmaceutical professionals, patients as well as their family members will find this book useful.
Combinational Immunotherapy of Cancer: Novel Targets, Mechanisms, and Strategies
Cancer immunotherapy, including immune checkpoint inhibitors (ICIs) and chimeric antigen receptor T-cell (CAR-T) therapy, has revolutionized the paradigm in cancer treatment. However, the clinical outcome of immunotherapy varies considerably among patients and only a minority of patients achieve long-term clinical benefits. This is largely attributed to the fact that existing cancer immunotherapies, which concentrate on several classical targets (CTAL-4, PD-1/PD-L1, etc.) and limited types of immune cell populations (T cells), are insufficient to cope with the complexity of highly heterogeneous tumor microenvironment (TME). This calls for more efforts to not only expand our toolbox for manip...
Die Relationalität des Subjektes im Kontext der Religionshermeneutik
Die in diesem Sammelband vereinigten Beitrage dokumentieren das mittlerweile neunte interdisziplinare Symposion, das vom Institut fur Kultur- und Geistesgeschichte Asiens der Osterreichischen Akademie der Wissenschaften veranstaltet und im September 2008 unter dem Titel aDas Subjekt als Prinzip der Relationalitat im Kontext der Religionshermeneutik in Wien abgehalten wurde. Bei diesem Symposion sollte gezeigt werden, dass in religionshermeneutischer Perspektive aReligion ohne eine Diskussion uber das Subjekt und ohne die Frage nach seiner Relationalitat unvollstandig bleibt. Alle Beitrage dieses Bandes nahern sich dem Problem, wie im Kontext einer religiosen Tradition Subjektivitat mit Relationalitat verbunden werden kann. Dem Subjekt fallt dabei stets eine doppelte Bedeutung zu. Einerseits meint die Relationalitat des Subjektes eine grundlegende Bezogenheit auf Transzendenz. Andererseits kennzeichnet Relationalitat ein Subjekt in Beziehung zu anderen Subjekten als begegnendes "Mitsein".
The Linji Lu and the Creation of Chan Orthodoxy
The Linji lu, or Record of Linji, ranks among the most famous and influential texts of the Chan and Zen traditions. Ostensibly containing the teachings of the Tang dynasty figure Linji Yixuan, the text has generally been accepted at face value, as reliable records of the teachings of this historical figure. In this book, Albert Welter offers the first systematic study of the Linji lu in a western language. Welter places the Linji lu in its historical context, showing how the text was manipulated over time by the Linji faction. Rather than recording the teachings of the illustrious patriarch of legend, the text reflects the motivations of Linji-faction descendants in the Song dynasty (9601279). The story of the Linji lu is not simply the story of one heroic figure, Linji Yixuan, but the story of an entire movement that sought validation through retrospective image making. The success of this effort is seen in Chan's rise to prominence. Drawing on the findings of Japanese scholars, Welter moves beyond the minutiae of textual analysis to place the development of Linji lu within the broader forces shaping the development of the Chinese Records of Sayings literary genre as a whole.
湖南医科大学学报
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