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Triple-negative Breast Cancer
Triple-negative breast cancer (TNBC) represents a challenge clinically due to the lack of actionable targets coupled with an aggressive disease course and a worse prognosis compared to other breast cancer subtypes. This book covers aspects of TNBC ranging from epidemiology, biology, molecular classification, to currently available and potentially new therapeutic options for TNBC. This book contains a range of recommended resources, including recent reviews, schematic illustrations, and information for patients with TNBC. Individuals including researchers and educators, practitioners, pharmaceutical professionals, patients as well as their family members will find this book useful.
Combinational Immunotherapy of Cancer: Novel Targets, Mechanisms, and Strategies
Cancer immunotherapy, including immune checkpoint inhibitors (ICIs) and chimeric antigen receptor T-cell (CAR-T) therapy, has revolutionized the paradigm in cancer treatment. However, the clinical outcome of immunotherapy varies considerably among patients and only a minority of patients achieve long-term clinical benefits. This is largely attributed to the fact that existing cancer immunotherapies, which concentrate on several classical targets (CTAL-4, PD-1/PD-L1, etc.) and limited types of immune cell populations (T cells), are insufficient to cope with the complexity of highly heterogeneous tumor microenvironment (TME). This calls for more efforts to not only expand our toolbox for manip...
Die Relationalität des Subjektes im Kontext der Religionshermeneutik
Die in diesem Sammelband vereinigten Beitrage dokumentieren das mittlerweile neunte interdisziplinare Symposion, das vom Institut fur Kultur- und Geistesgeschichte Asiens der Osterreichischen Akademie der Wissenschaften veranstaltet und im September 2008 unter dem Titel aDas Subjekt als Prinzip der Relationalitat im Kontext der Religionshermeneutik in Wien abgehalten wurde. Bei diesem Symposion sollte gezeigt werden, dass in religionshermeneutischer Perspektive aReligion ohne eine Diskussion uber das Subjekt und ohne die Frage nach seiner Relationalitat unvollstandig bleibt. Alle Beitrage dieses Bandes nahern sich dem Problem, wie im Kontext einer religiosen Tradition Subjektivitat mit Relationalitat verbunden werden kann. Dem Subjekt fallt dabei stets eine doppelte Bedeutung zu. Einerseits meint die Relationalitat des Subjektes eine grundlegende Bezogenheit auf Transzendenz. Andererseits kennzeichnet Relationalitat ein Subjekt in Beziehung zu anderen Subjekten als begegnendes "Mitsein".
Myths of Mountains and Seas
In the four seas and eight wastelands, the Mystic Maiden offered up the secret arts of the Mountain and Sea Realm, the Seven Domains of the Nine Prefectures, and the Nine Tripod Commerce. When this cauldron reached ten percent completion, the rain of blood would rain down upon the deities and devils. The River Diagram appeared, as did Luo Shu. The human world was in turmoil. It was rumored that these nine cauldrons were the ones that had gained the world. However, he did not know that the treasures of the nine cauldrons were all in the Mountain Sea Secret Art that was drawn on the cauldron. After that, the nine cauldrons sank into the Luo River, disappearing without a trace. The five paths of the world, the Wonder Gate, the Illusion Dao, the Mountain Sect, the Sea Sect, the Scripture Pavilion, and the five sects' heirs, each had their own secret treasures, all for the sake of obtaining the Mountain Sea secret arts within the nine cauldrons. This fight lasted for thousands of years ...
Nanozymology
This book introduces the new concept of “nanozyme”, which refers to nanomaterials with intrinsic enzymatic activity, rather than nanomaterials with biological enzymes incorporated on the surface. The book presents the cutting-edge advances in nanozyme, with emphasis on state-of-the-art applications in many important fields, such as in the biomedical fields and for environmental protection. The nanozyme is a totally new type of artificial enzyme and exhibits huge advantages over natural enzymes, including greater stability, low cost, versatility, simplicity, and suitability for industry. It is of interest to university researchers, R&D engineers, as well as graduate students in nanoscience and technology, and biology wishing to learn the core principles, methods, and the corresponding applications of “nanozyme”.
