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Developmental Biology and Regulation of Osteoclasts
  • Language: en
  • Pages: 213
Micro-Tomographic Atlas of the Mouse Skeleton
  • Language: en
  • Pages: 196

Micro-Tomographic Atlas of the Mouse Skeleton

The Micro-Tomographic Atlas of the Mouse Skeleton provides a unique systematic description of all calcified components of the mouse. It includes about 200 high resolution, two and three dimensional m CT images of the exterior and interiors of all bones and joints. In addition, the spatial relationship of bones within complex skeletal units is also described. The images are accompanied by detailed explanatory text, thus highlighting special features and newly reported structures. The Atlas fulfils an emerging need for a comprehensive reference to assist both trained and in-training researchers.

Dietary Protein for Performance, Health and Disease Management
  • Language: en
  • Pages: 132
Recent Advances in Oral Immunity
  • Language: en
  • Pages: 164

Recent Advances in Oral Immunity

The oral mucosa is a challenging environment from an immunological perspective, containing discrete niches with a unique architecture and function that requires precise adjustment of the immune system. Being the port of entry to the gastrointestinal and respiratory tracts, the oral cavity is also constantly challenged by antigens derived from air and food. Moreover, the oral cavity is the sole tissue of the body harboring a hard surface (i.e. the tooth) that is exposed to the hostile external environment, resulting in the formation of a complex biofilm that has local and systemic effects. To deal with such challenges, the oral immune system aims to prevent the invasion of pathogens/harmful antigens and to tolerate non-pathogenic counterparts in order to maintain homeostasis. In recent years, numerous studies have addressed these fundamental issues, revealing sophisticated mechanisms engaged by the immune system to maintain oral mucosal homeostasis and to combat various immunological insults. Some of these studies have identified novel immunological mechanisms, emphasizing the uniqueness of the oral immune system and the necessity to further investigate its functions.

Recent Advances in the Genetics of Osteoporosis
  • Language: en
  • Pages: 119

Recent Advances in the Genetics of Osteoporosis

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Skeletal stem/progenitor cells and their environment in bone regeneration
  • Language: en
  • Pages: 146

Skeletal stem/progenitor cells and their environment in bone regeneration

The skeleton plays essential physiological functions throughout life from structural support and movement for the entire body, to storage of minerals and hematopoiesis, as well as endocrine functions. Skeletal integrity is maintained by the efficient remodeling and repair abilities of bone tissue that involves multiple skeletal stem/progenitor cell (SSPC) populations within bone compartments. These populations change their properties during development, growth and aging and can be affected by disease and trauma. SSPCs also interact with bone marrow, blood vessels, nerves, and adjacent soft tissues. The close communication between various skeletal and extra-skeletal cell populations is required for bone maintenance and function, and during bone regeneration following injury or trauma. Tremendous advances have been made in the past decade on the characterization of SSPCs that support skeletal regeneration. Yet, we still do not fully understand the basic cellular and molecular mechanisms underlying the high regenerative potential of bone and how disease or trauma can reduce SSPC functions and lead to impaired healing.

Continuity and Discontinuity in the Peopling of Europe
  • Language: en
  • Pages: 390

Continuity and Discontinuity in the Peopling of Europe

Since the Western world first became aware of the existence of Neanderthals, this Pleistocene human has been a regular focus of interest among specialists and also among the general public. In fact, we know far more about Neanderthals than we do about any other extinct human population. Furthermore, over the past 150 years no other palaeospecies has been such a constant source of discussion and fierce debate among palaeoanthropologists and archaeologists. This book presents the status of our knowledge as well as the methods and techniques used to study this extinct population and it suggests perspectives for future research.

Dental Perspectives on Human Evolution
  • Language: en
  • Pages: 419

Dental Perspectives on Human Evolution

The objective of the volume is to bring together, in one collection, the most innovative dental anthropological research as it pertains to the study of hominid evolution. In the past few decades both the numbers of hominid dental fossils and the sophistication of the techniques used to analyze them have increased substantially. The book’s contributions focus on dental morphometrics, growth and development, diet and dental evolution.

A Psychiatrist's View of Marijuana
  • Language: en
  • Pages: 257

A Psychiatrist's View of Marijuana

An essential guide covering the scientific knowledge and communication skills required to deliver objective patient advice about marijuana use.

Therapeutic Potential of the Cannabinoid CB2 Receptor
  • Language: en
  • Pages: 178