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Metabolism and Immune Tolerance
Historically the study of the immune system and metabolism have been two very separate fields. In recent years, a growing literature has emerged illustrating how the multiple processes of cellular metabolism are intricately linked to several aspects of immune function and development. This Research Topic covers recent progress in the field now known as “Immunometabolism” and the role of metabolism in immune tolerance. Immune tolerance is operationally defined as a state where a host’s immune system is balanced such that although self-reactive lymphocytes are present, they are kept in check by immune regulation. Perturbations to this homeostasis may result in self-reactive lymphocytes g...
Autoimmunity
Autoimmunity is defined as an immune response against a self-antigen. This abnormal immune response can lead to tissue damage and to the development of autoimmune disease. From organ-specific autoimmune diseases, such as myasthenia gravis, to non-organ-specific, such as systemic lupus erythematosus, autoimmune diseases represent a heterogeneous group of disorders which affect approximately 6% of the population. The pathogenesis of many autoimmune diseases is complex and remains not completely understood. The aim of this book is to present current knowledge regarding pathogenic mechanisms of autoimmune diseases, clinical aspects of specific autoimmune diseases, like vitiligo, celiac disease and autoimmune liver disease, as well as insights regarding specific therapies.
Diseases of the Liver and Biliary System in Children
This market-leading book, with comprehensive coverage of the entire spectrum of liver disease in children, returns with 12 brand new chapters covering key areas in liver transplantation, viral hepatitis, and liver disease in infancy. Authored by the world’s leading hepatologists and pediatricians and expertly edited by Deirdre Kelly, it covers the entire topic from pathology to diagnosis and clinical management, and in all stages of childhood from the unborn baby through to infancy, and from childhood to the transition into adolescence. Hepatologists, pediatricians and gastroenterologists of all levels will find it an essential tool to consult time and time again
Debating Democratization in Myanmar
Is Myanmar (Burma) democratizing, or is it moving towards a new form of authoritarianism, perhaps one more consonant with other contemporary authoritarian regimes in Asia? Coming at a critical time, and one of growing interest in this Southeast Asian country among researchers and policy-makers, Debating Democratization in Myanmar addresses this complex question from a range of disciplinary and professional perspectives. Chapters by leading international scholars and practitioners, activists and politicians from Myanmar and around the world cover political and economic updates, as well as the problems of democratization; the re-engagement of democratic activists and exiles in domestic affairs; the new parliament, the electoral system, and everyday politics; prospects for the economy; ethnic cooperation, contestation and conflict; the role of the army and police forces; and conditions for women. Together they constitute an empirically deep and analytically rich source of readable and relevant material for anyone keen to obtain a greater understanding of what is happening in Myanmar today, and why.
Steele's Colon and Rectal Surgery
Offering comprehensive coverage of all diseases and conditions affecting the colon, rectum, and anus, Steele’s Colon and Rectal Surgery provides authoritative guidance on the full range of today’s operative procedures. Edited by Dr. Scott R. Steele, Chairman of the Department of Colorectal Surgery at the Cleveland Clinic, and section editors Drs. Justin A. Maykel, Amy L. Lightner, and Joshua I.S. Bleier, this new reference contains 81 concise, tightly focused chapters that take you step by step through each procedure, guided by the knowledge and expertise of key leaders in the field from across the world.
