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Cancer Immunotherapy – Diagnostic and Therapeutic Strategies to Enhance Antitumoral Efficacies whilst Minimizing Toxicity
  • Language: en
  • Pages: 221

Cancer Immunotherapy – Diagnostic and Therapeutic Strategies to Enhance Antitumoral Efficacies whilst Minimizing Toxicity

With their unprecedented success, cancer immunotherapies including immune checkpoint inhibitors (ICIs), cancer vaccines, adoptive cell therapy (ATC), and immunomodulators are being increasingly used for various malignancies. Distinct from traditional treatments including surgery, radiation therapy, and chemotherapy, immunotherapeutics attempt to create long-lasting anti-tumor effects. However, only a minority of patients experience long-term benefits to single-agent immunotherapy, and most patients do not have initial responses to the immunotherapy or develop relapse after promising initial responses. Strategies to overcome immunotherapy resistance include (1) the development of biomarkers t...

Cancer Research
  • Language: en
  • Pages: 964

Cancer Research

  • Type: Book
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  • Published: 2006-07
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  • Publisher: Unknown

None

The Journal of Immunology
  • Language: en
  • Pages: 692

The Journal of Immunology

  • Type: Book
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  • Published: 2009
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  • Publisher: Unknown

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Crosstalk: Skin Cells and Immune Cells in Inflammatory Skin Diseases
  • Language: en
  • Pages: 196

Crosstalk: Skin Cells and Immune Cells in Inflammatory Skin Diseases

The skin is the human body's largest organ consisting of two layers: epidermis and dermis, and appendages: hair, and sweat glands. The skin not only wraps the body but also protects it from external stimuli and infection, perceives sensations such as pain and itch, and coordinates with various circulating immune cells for immune response/regulation. Recent studies have shown that inflammatory skin diseases, including psoriasis and atopic dermatitis, harbor systemic inflammation/immune abnormalities such as strong Th activation and expansion of specific immune cell subsets. Novel biologics and small molecule inhibitors targeting specific biomarkers and immune signals are much more effective and safer than conventional systemic therapies for these skin diseases.

Science
  • Language: en
  • Pages: 828

Science

  • Type: Book
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  • Published: 2009
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  • Publisher: Unknown

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Sex Bias in Autoimmunity: From Animal Models to Clinical Research and Applications
  • Language: en
  • Pages: 116

Sex Bias in Autoimmunity: From Animal Models to Clinical Research and Applications

Autoimmune diseases are characterized by an abnormal and self-directed immune response leading to damage and dysfunction of multiple organs and tissues. Most autoimmune diseases are recognized as affecting disproportionately more women than men, suggesting a crucial role of sex hormones in modulating immune responses, with estrogens being postulated as enhancing autoimmunity and androgens playing a protective role. It is also widely acknowledged that there is an overwhelming male bias in non-human (animal) studies of autoimmune diseases, while studies of both sexes in human research frequently fail to analyze results by sex. Underrepresentation of females in animal models of autoimmune disea...

Official Gazette of the United States Patent and Trademark Office
  • Language: en
  • Pages: 998

Official Gazette of the United States Patent and Trademark Office

  • Type: Book
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  • Published: 2000
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  • Publisher: Unknown

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Official Gazette of the United States Patent and Trademark Office
  • Language: en
  • Pages: 1448

Official Gazette of the United States Patent and Trademark Office

  • Type: Book
  • -
  • Published: 2001
  • -
  • Publisher: Unknown

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Focus On: 100 Most Popular South Korean Television Actresses
  • Language: en
  • Pages: 554

Focus On: 100 Most Popular South Korean Television Actresses

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