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Enzyme Defects and Immune Dysfunction
The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.
Advances in Genetics
Advances in Genetics
The Carbonic Anhydrases
As we approach the twenty-first century the problems of industrialization are evident: we find there is a greenhouse effect, the ozone layer is being depleted, the rain is acidified, and there is a terrible problem of increasing C0 concentrations in the atmo 2 sphere. The carbonic anhydrases are a unique family of enzymes that solve these problems in the human body: they are responsible for converting C0 (a gas) to 2 HC0-, which is the biggest intracellular buffer, with a concomitant decrease in a 3 hydroxyl ion. Globally, the functions of the carbonic anhydrases in photosynthesis in rain forests and in the algae and plankton that cover our oceans indicate that they are also of utmost import...
Isoenzymes
The increased interest in multiple forms of enzymes that began with the application of new methods of fractionation to preparations of enzymes and other proteins some 25 years ago led quickly to an appreciation that the existence of enzymes in multiple forms, or isoenzymes, is a general phenomenon. The results of pioneering studies and those which followed in the early years of isoenzyme research consisted, not surprisingly, mainly of descriptions of the existence and characteristics of hetero geneity in various enzyme systems. Summaries of these results were provided in books such as J . H. Wilkinson's I soenzymes, the first edition of which appeared in 1965. Some clearer ideas of the natur...
Uric Acid
Uric acid has attracted the attention of scientists from a broad spectrum of disciplines, and in recent years dramatic progress has occurred within many of these disciplines. This volume is designed to fill void in the field. Major works in the past five years have provided comprehensive reviews of disorders of uric acid metabolism for the clinical (1-3) as well as short reports of recent progress for the interested scholar (4, 5). In Uric Acid the reader will find extensive reviews of relevant topics selected largely by virtue of recent progress in the field and written by those who, to a considerable extent, qre responsible for that progress. Seven chapters are dedicated to a description o...
The Carbonic Anhydrases
Carbonic anhydrase (CA) is a seemingly ubiquitous enzyme of profound physiological importance, which plays essential roles in respiration, acid-base homeostasis, bone resorption, calcification, photosynthesis, several biosynthetic pathways and a variety of processes involving ion, gas and fluid transfer. This enzyme, which is present in at least three gene families (a, ß, ?), has found favour as a model for the study of evolution of gene families and for site-directed mutagenesis in structure/function relationships, for protein folding and for transgenic and gene target studies. Since the early use of CA inhibitors as diuretics and in treating congestive heart failure, the enzyme has been target of considerable clinical attention. Much of this is now focused on endeavours to produce a new generation of such drugs for the effective treatment of glaucoma and other potential applications. Recent data, suggesting links between CA and various disease processes, including cancer, have stimulated further...
Disorders of Voluntary Muscle
Rewritten and redesigned, this remains the one essential text on the diseases of skeletal muscle.
Dynamics and Developments of Social Structures and Networks in Prehistoric and Protohistoric Cyprus
This volume substantiates the island of Cyprus as an important player in the history of the ancient Eastern Mediterranean and Near East, and presents new theoretical and analytical approaches. The Cypriot Neolithic, Chalcolithic, and Bronze Age are characterised by an increasing complexity of social and political organisation, economic systems and networks. The book discusses and defines how specific types of material datasets and assemblages, such as architecture, artefacts, and ecofacts, and their contextualisation can form the basis of interpretative models of social structures and networks in ancient Cyprus. This is explored through four main themes: approaches to social dynamics; social...
Muscle Physiology and Biochemistry
The papers in this volume were contributed by close friends, co-workers and pupils of Professor Setsuro Ebashi. They are dedicated to him to commemorate his great and pioneering contribution to the advancement of muscle physiology and biochemistry, which, in time, exerted a great influence on the whole field of life science. We believe that this issue reveals the present state of research on muscle and/or calcium that was opened up by Professor Ebashi.
