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The analysis of circulating tumor cells (CTCs) as a real-time liquid biopsy approach can be used to obtain new insights into metastasis biology, and as companion diagnostics to improve the stratification of therapies and to obtain insights into the therapy-induced selection of cancer cells. In this book, we will cover all the different facets of CTCs to assemble a huge corpus of knowledge on cancer dissemination: technologies for their enrichment, detection, and characterization; their analysis at the single-cell level; their journey as CTC microemboli; their clinical relevance; their biology with the epithelial-to-mesenchymal transition (EMT); their stem-cell properties; their potential to initiate metastasis at distant sites; their ex vivo expansion; and their escape from the immune system.
Cancer is a multifaceted disease and overwhelmingly increasing experimental evidence has helped us to develop a deeper understanding of the role of signal transduction cascades in cancer development and progression. Tissue microarrays and next generation sequencing technologies have assisted us to gather missing pieces of jigsaw puzzle and we now know that deregulation of spatio-temporally controlled signaling cascades play fundamental role in metastasis and resistance against wide ranging therapeutics. This book offers a balanced overview of the rapidly emerging cutting edge research in molecular oncology and good source of knowledge for established oncologists, basic and medical students and pharmaceutical industry associated R&D departments.
An introduction to the emerging field of cancer physics, integrating cancer biology with approaches from theoretical and applied physics.
"Education, arts and social sciences, natural and technical sciences in the United States and Canada".
This book presents ideas and guidance about human development to enhance medical education's ability to form competent and responsible physicians.
Tells the story of the growing Chinese Navy - The People's Liberation Army Navy (PLAN) - and its expanding capabilities, evolving roles and military implications for the USA. Divided into four thematic sections, this special collection of essays surveys and analyzes the most important aspects of China's navel modernization.
"This comprehensive, six-volume collection addresses all aspects of online and distance learning, including information communication technologies applied to education, virtual classrooms, pedagogical systems, Web-based learning, library information systems, virtual universities, and more. It enables libraries to provide a foundational reference to meet the information needs of researchers, educators, practitioners, administrators, and other stakeholders in online and distance learning"--Provided by publisher.
It's the 1970s, and the world's most terrifying Kaiju smash their way through New York City! As Godzilla and Hedorah do battle above, down below Todd Hopkins is racing across Manhattan in a desperate bid to save the only scientist who can stop the chaos and drive the monsters back into the sea. But before the day is over, secrets will be revealed and terrible choices made to save the city from utter destruction! Writer Paul Allor (TMNT, G.I. Joe) and artist E.J. Su (Transformers, Godzilla: Legends) join forces to bring the premiere Godzilla Versus quarterly one-shot to life in explosively shocking fashion! And each stand-alone issue features special wrestling poster-themed retailer incentive variants by fan-favorite artist Jeffrey Veregge (Transformers, Judge Dredd).