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Neurophilosophy and Alzheimer's Disease
Any mention of the relationship, still poorly understood, between body (or brain) and mind invariably invokes the name of Descartes, who is often thought of as the father of modern philosophy and perhaps of neurophilosophy. Although a native of the heart of France (the region around Tours), Rene Descartes travelled widely, as everyone knows, especially to Holland and Sweden. It should come as no surprise, that the Congress of Neurophilosophy and Alzheimer's Disease was the first in the series of Fondation Ipsen Colloques Medecine et Recherche to be held outside France. The meeting was held in San Diego (California) on January 11, 1991. This venue was chosen for a number of reasons. The Unive...
Immunology and Alzheimer’s Diseasee
Alzheimer's disease is one of the major scientific, medical and social challenges of our time. This book, the first in the new series Research and Perspectives in Alzheimer's Disease, presents a particularly up-to-date approach of immunological and biochemical aspects. It is written by the most outstanding scientists and contains recent data. The following are among the most interesting ideas contained in this book: - Alzheimer's disease is a cerebral form of amyloidosis. - some data are in accordance with an immunological hypothesis of this disease. - degeneration of microvessels - including amyloid angiopathy - could be very important in the changes in the brain with Alzheimer's disease. - the molecular study of A4 protein and its precursor is important for the understanding of the disease. This synthesis by prominent scientists provides a stimulating hypothesis about the determinism of the disease.
Neuronal Grafting and Alzheimer’s Disease
Alzheimer's disease is one of the major scientific, medical and social challenges of our time. This book (the third volume of proceedings of the Colloques Médecine et Recherche of the Fondation Ipsen pour la Recherche Thérapeutique) is dedicated to neuronal grafting and Alzheimer's disease. The wealth of basic information presented testifies to the progress that has been achieved in intracerebral grafting and to the utility of intracerebral grafting as a tool for the understanding of brain development, adult neuronal plasticity and age-related pathology. An answer to the question, whether neuronal grafting will be useful as a therapy for Alzheimer's disease, must wait for a better understanding of the disease and the identification of animal models that can be used to test potential therapies. Meanwhile, the tool of intracerebral grafting may, in the future, be used to address the pathophysiology of Alzheimer's disease.
Taking Haiti
The U.S. invasion of Haiti in July 1915 marked the start of a military occupation that lasted for nineteen years--and fed an American fascination with Haiti that flourished even longer. Exploring the cultural dimensions of U.S. contact with Haiti during the occupation and its aftermath, Mary Renda shows that what Americans thought and wrote about Haiti during those years contributed in crucial and unexpected ways to an emerging culture of U.S. imperialism. At the heart of this emerging culture, Renda argues, was American paternalism, which saw Haitians as wards of the United States. She explores the ways in which diverse Americans--including activists, intellectuals, artists, missionaries, m...
Growth Factors and Alzheimer’s Disease
The study of the relationships between neurotrophic factors (NGF, FGF, amyloid) and neurodegenerative disorders (especially Alzheimer's disease) is of major importance not only for understanding the pathogenesis of the latter, but also for the pharmacological approach to this disease. Information on the subject stemming from the symposium in Strasbourg in April, 1990, organized by the Fondation IPSEN is presented in this book. It provides stimulating hypotheses about the possible role of growth factors in the generation of senile plaques, the process of degeneration and regeneration in Alzheimer's disease, the expression of the gene of NGF and the possible use of NGF in treatment.
Ageing and Dementia
Ageing and dementia are closely related conditions. Increasing age of the general population causes increasing incidence of dementing disorders in later life, although cognitive impairment is not necessarily a consequence of advancing age. The book presents the papers of the International Symposium on Ageing and Dementia, October 17–19, 1997 in Graz, where internationally renowned experts in the field of ageing and dementia gave an overview of the current knowledge about the epidemiology, pathomorphology, clinical diagnosis and course of brain ageing processes and related dementing disorders, biochemical markers and imaging procedures for the diagnosis of Alzheimer’s disease and current ...
Alzheimer’s Disease: Lessons from Cell Biology
Like the unflinching gaze of Captain Ahab walking the deck of the Pequod, Alzheimer researchers have had their sights fixed firmly on the disease for many years. Now, as this volume amply demonstrates, accomplished researchers from other fields, who have thought deeply about cell biological problems are applying their insights to Alzheimer's disease. The contri butions here represent the text versions of the proceedings from the tenth "Colloque medecine et recherche" of the Fondation IPSEN devoted to research on Alzheimer's disease. The symposium, entitled "Alzheimer's Disease: Lessons from Cell Biology" was held in Paris on April 25, 1994. As is apparent from the varied backgrounds of the c...
Alzheimer: 100 Years and Beyond
Few medical or scientific addresses have so unmistakeably made history as the presentation delivered by Alois Alzheimer on November 4, 1906 in Tübingen. The celebratory event "Alzheimer 100 Years and Beyond" was organized through the Alzheimer community in Germany and worldwide, in collaboration with the Fondation Ipsen. This volume, a collection of articles by the invited speakers and of a few other prominent researchers, is published as a record of those events.
Heterogeneity of Alzheimer’s Disease
The term "Alzheimer's disease" is currently used to refer to senile and also presenile dementia, but the heterogeneity of this disorder is demonstrated in many of its aspects. This is of great theoretical interest, and with the appearance of new therapeutic interventions, it may well also start to have very significant practical importance. To shed some light on the debate, the Fondation Ipsen organized an international symposium which took place on April 6, 1992. This volume contains the proceedings of this meeting, which was attended by researchers in epidemiology, clinical neurology and geriatrics, neuropsychology, neuropathology, molecular biology, and genetics.
Apolipoprotein E and Alzheimer’s Disease
There is now considerable genetic evidence that the type 4 allele of the apolipoprotein E gene is a major susceptibility factor associated with late-onset Alzheimer's disease, the common form of the disease defined as starting after sixty years of age. The role of apolipoprotein E in normal brain metabolism and in the pathogenesis of Alzheimer's disease are new and exciting avenues of research. This book, written by the most outstanding scientists in this new filed, is the first presentation of results concerning the implications of apolipoprotein E on the genetics, cell biology, neuropathology, biochemistry, and therapeutic management of Alzheimer's disease.
