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The cerebrospinal fluid (CSF) is an invaluable diagnostic tool in clinical neurology, not only in the evaluation of inflammatory, degenerative, and malignant diseases of the nervous system, but also in the diagnosis of all forms of cerebral and subarachnoidal bleedings. The CSF can be easily obtained by lumbar puncture and a set of basic analyses can be conducted using relatively simple laboratory methods. By combining different CSF parameters, a wide range of diagnostic entities can be identified. However, properly interpreting the test results requires a high level of expertise and cannot be achieved by just reporting on individual analytic values. This book covers essential aspects of cer...
This title provides an extremely helpful analysis of genes that may be associated with autoimmunity, and answers questions such as how these genes can be identified, and how the functions of the gene products can be elucidated. Incorporating data on disease-associated chromosomal loci that has been accumulated from inbred mice, the title: descibes how some susceptibility loci may be common to many diseases, whereas others are relatively disease specific discusses the importance of developing criteria for establishing the significance of these different categories of disease-associated loci.
The availability of powerful genome-wide association study technology, during the last five years, has shown that most of the “new” MS susceptibility loci are immune-response genes. It is clear that there is much novelty in the field of MS immunology, which has served as an impetus to invest in new therapies. Notably, most if not all of these are immunotherapies. Even the equally exciting field of cell-based therapies and neuro-regeneration may well rely on cells or growth factors that are no less immunomodulators than restorative of myelin and neural cell function. Multiple Sclerosis Immunology looks at MS immunology as the basis for the present and—even more—the future of treatments for this complex autoimmune condition. Both editors are immunologists, as well as clinical neurologists, and appreciate the importance of a sustained dialogue between basic and clinical scientists to ensure that “translation” is real and not just virtual.
This volume reviews the most recent advances in the understanding of cellular and molecular mechanisms for immune responses and immune regulation. The books editor, Dr. Zhang, is well-known internationally, particularly in the field of multiple sclerosis and T-cell vaccination as a potential treatment of multiple sclerosis. He has much experience and expertise in both basic and clinical aspects of autoimmune disease.
Readership: Geneticists and clinicians worldwide in addition to graduate students and researchers interested in populations and genomics
Beginning with an analysis of the complex relationship between fascism and the post-war extreme right, the book discusses both contemporary parties and the cultural and intellectual influences of the European New Right as well as patterns of socialization and mobilization. It then analyses the effects of a range of factors on the ideological development of right-wing extremism including anti-Semitism, Islamophobia, religious extremism and the approach towards Europe (and the European Union).The final sections investigate a number of activist manifestations of the extreme right from youth participation and the white power music scene to transnational rallies, the Internet and football hooliganism. In the process, the book questions the notion that the contemporary extreme right is either completely novel or fully populist in character. Drawing together a wide range of contributors, this is essential reading for all those with an interest in contemporary extremism and fascism. The book is a companion volume to Mapping the Extreme Right (Routledge, 2012) which has the same editors.
This practical guide provides an algorithm for diagnosis and treatment, from ‘having some problem with vision’, via diagnosis of cause and background, to treatment and eventually to rehabilitation. Following on from introductory sections devoted to the role of neuro-ophthalmology, recent developments in the field, and an overview of neuro-ophthalmological examinations, there are sections devoted to the different parts of the visual system, and finally a section on rehabilitation. Neuro-ophthalmology is aimed at ophthalmologists, neurologists, neurosurgeons, traumatologists, neuroradiologists, experts in cardiology and stroke, and trainees in these areas. It will also be of interest to neuro-rehabilitation specialists, neuropsychologists, and those working in typhlopedagogy and health informatics.