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The complex landscape of breast cancer requires distinct strategies for the management of various molecular subtypes of this disease. Rapid advances in the field of molecular biology have been bewildering for those involved in its study and management. “Molecular Pathology of Breast Cancer” aims to close this knowledge gap by discussing comprehensively the evolution, biological basis and clinical applications with a focus on the “what, when, and how” of the most significant molecular markers known to date. These markers are evaluated in the context of genomic, transcriptomic and proteomic profiles, which is integral to the practice of precision medicine. The application of next gener...
Globalization of legal traffic and the inherent necessity of having to litigate in foreign courts or to enforce judgments in other countries considerably complicate civil proceedings due to great differences in civil procedure. This may consequently jeopardize access to justice. This triggers the debate on the need for harmonization of civil procedure. In recent years, this debate has gained in importance because of new legislative and practical developments both at the European and the global level. This book discusses the globalization and harmonization of civil procedure from the angles of legal history, law and economics and (European) policy. Attention is paid to the interaction with pr...
The high morbidity and mortality due to gynecologic cancer calls for much-needed efforts to provide an early diagnosis. Using novel approaches and concepts applied to the precursors of gynecological malignancies and their early carcinogenesis, the clinical-pathologic correlations of the disease are highlighted in this book.Presented in a concise manner, the book stands out from existing publications in its description of histopathological changes of the female genital tract that precede the development of cancer. It also describes the updated clinical and biological correlations of gynecologic cancer, as well as the early and often silent stages of the cancer. In addition, essential data from the literature on recent scientific progress in the field of gynecologic cancer is discussed, including original research work carried out by the authors.
The AACR Annual Meeting is a must-attend event for cancer researchers and the broader cancer community. This year's theme, "Delivering Cures Through Cancer Science," reinforces the inextricable link between research and advances in patient care. The theme will be evident throughout the meeting as the latest, most exciting discoveries are presented in every area of cancer research. There will be a number of presentations that include exciting new data from cutting-edge clinical trials as well as companion presentations that spotlight the science behind the trials and implications for delivering improved care to patients. This book contains abstracts 1-2696 presented on April 17-18, 2016, at the AACR Annual Meeting.
This textbook provides a comprehensive overview of the state of the art knowledge of breast cancer management for the modern breast surgeon. It covers all aspects of multidisciplinary care including primary breast and axillary surgery, reconstruction and oncoplastic techniques, external beam radiotherapy and newer techniques such as tomotherapy, intraoperative radiotherapy and brachytherapy. In addition, systemic therapies including chemotherapy, the latest biological targeted therapies and endocrine therapies are covered. Readers can find out about other important aspects of breast cancer such as genetics, screening, imaging and long-term health among others. Chapters take the reader throug...
Das Problem des nachehelichen Unterhalts gehört zu den brisantesten Problemen des Familienrechts. Der deutsche nacheheliche Unterhalt wurde durch das UÄndG von 2007 reformiert, vor diesem Hintergrund präsentiert diese rechtsvergleichend angelegte Arbeit die aktuelle Rechtslage des deutschen, spanischen und chilenischen Rechts. Da sich die Veränderungen auf gesellschaftliche Entwicklungen im Zusammenhang mit der Familie und der Lebensgestaltung des Einzelnen gründen, beschäftigt sich die Untersuchung auch mit den soziologischen Aspekten jeder Rechtsordnung. Mittelpunkt dieser Arbeit ist, zu erkennen und zu durchschauen, welche grundlegenden und signifikanten Parallelen und Differenzen i...
Hormonal influences, both natural and iatrogenic, are implicated in the most frequent health issues of women. Endometrial cancer is now the most common gynecologic cancer in the United States and the industrialized world. This cancer is strongly related to hormonal and metabolic factors. In addition, breast cancer treated with hormone therapy (Tamoxifen) may, in some cases, be associated with uterine pathology. Hormone therapy is used to improve the physiological effects and counteract abnormal and deleterious effects of “natural” hormonal activity. Millions of women receive hormone therapy at some point of their life: using oral contraceptives, reproductive technology, treatment for pos...
India is a country having strong cultural foundation and high moral values. Marriage (matrimonial relationship or wedlock) in India has secured a sacred place and it is a general conception that marriage is a heavenly creature which is celebrated on earth. In India, marriage is a sacred bonding between two heterogeneous persons by which kinship is created and mutual rights and obligations are generated by this relationship. It is also a general conception that cohabitation between man and woman can only be done through bonding of marriage and for cohabitation, no other relationships is allowed between them. Marriage is a divine concept which has been practiced since ages. Interpersonal relat...
"This book provides methodologies and developments of grid technologies applied in different fields of life sciences"--Provided by publisher.
This book aims to redress the balance in the field of Contemporary Philosophy, considered predominantly male, by highlighting the philosophical achievements of various female figures during the period 1870-1970. Contemporary Philosophy is generally presented by its historians as a field founded entirely by men, with no prominent female contributors. Historical investigation of the development of contemporary analytic philosophy, for example, usually centres around Frege, Russell, and Wittgenstein, with occasional ventures into Moore or the Vienna Circle. Such accounts leave out vast swathes of the historical record (from early 19th century to 20th century), in particular the women, including...