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Functional Imaging and Modeling of the Heart
This book constitutes the refereed proceedings of the 4th International Conference on Functional Imaging and Modeling of the Heart, FIMH 2007, held in Salt Lake City, UT, USA in June 2007. The contributions describe both experimental and computational studies and cover topics such as imaging and image analysis, cardiac electrophysiology, electro- and magnetocardiography, cardiac mechanics and clinical application, imaging and anatomical modeling.
Safety Pharmacology - Risk Assessment QT Interval Prolongation and Beyond
Current regulatory guidelines for cardiac safety utilize hERG block and QT interval prolongation as risk markers. This strategy has been successful at preventing harmful drugs from being marketed, but criticized for leading to early withdrawal of potentially safe drugs. Here we collected a series of articles presenting new technological and conceptual advances, including refinement of ex vivo and in vitro assays, screens and models, and in silico approaches reflecting the increasing effort that has been put forward by regulatory agencies, industry, and academia to try and address the need of a more accurate, mechanistically-based paradigm of proarrhythmic potential of drugs. This Research Topic is dedicated to the memory of Dr. J. Jeremy Rice, our wonderful friend and colleague.
Familial Cardiomyopathies
This volume covers the latest advances in technologies that look at familial cardiomyopathies in greater detail, and provides new computational and experimental models that model, study, and detect disease at earlier stages. Together, this allows interdisciplinary research experiments to provide new insights for the development of novel interventions that slow, stop, or even reverse the disease process. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and practical, Familial Cardiomyopathies: Methods and Protocols aims to inspire further development of techniques used to study myocardial disease and the development of new, sarcomere-targeted therapeutic approaches for the maintenance of heart health and the treatment of heart failure.
Cardiovascular Signaling in Health and Disease
This contributed volume focuses on cardiovascular diseases (CVDs), and explores the ways in which signaling mechanisms at the biochemical, molecular, and cellular levels in the blood vessels (vascular) and heart contribute to the underlying causes of development and progression of the CVDs. This volume covers unique topics such as oxidant signaling in vascular and heart diseases and health, cytoskeletal signaling in vascular health and disease, phospholipase signaling in CVDs, lipid signaling in vascular and myocardial health and diseases, and drug discovery in cellular signaling for cardiovascular diseases. This book assembles the most important discoveries made by leaders on the cellular signaling mechanisms operating behind the development and progression of life-threatening CVDs. It is an extremely useful resource for the investigators in the field of CVDs, and opens the discussion for further discovery of efficient management and effective treatment of the CVDs.
Textbook of Ion Channels Volume III
Gives newcomers to the field a foundation in ion channel properties Details up-to-date techniques used in the study of ion channels, including fluorescence spectroscopy, x-ray crystallography, and electrophysiology Links the physiology of ion channels to diseases, such as cardiovascular diseases and cystic fibrosis Includes case studies and a glossary
Computational Physiology
This open access volume compiles student reports from the 2022 Simula Summer School in Computational Physiology. The reports provide an overview of some tools available to model physiology in excitable tissues across scales and scientific questions. In 2022, Simula held the eighth annual Summer School in Computational Physiology in collaboration with the University of Oslo (UiO) and the University of California, San Diego (UCSD). Each year, the course focuses on modeling excitable tissues, with a special interest in cardiac physiology and neuroscience. Group research projects conducted by graduate students from around the world result in reports addressing problems of physiological importance. Reports may not necessarily represent new scientific results; rather, they can reproduce or supplement earlier studies. Reports from seven of the summer projects are included as separate chapters. The topics represented include multiscale mechanics, electrophysiology, pharmacology, and machine learning.
Atrial Fibrillation
Atrial fibrillation is a rapidly evolving epidemic associated with increased cardiovascular morbidity and mortality, and its prevalence has increased over the past few decades. In the past few years, the recent understanding of the diverse mechanisms of this arrhythmia has lead to the improvement of our therapeutic strategies. However, many clinicians have still felt the frustration in management of this commonly encountered arrhythmia. This book contains a spectrum of different topics from bench to bedside in atrial fibrillation. We strongly believe that scientists, cardiologists and electrophysiologists will find this book very informative and useful and the references cited in each chapter will definitely act as an additional source of information for readers.
Towards Personalized Models of the Cardiovascular System Using 4D Flow MRI
Current diagnostic tools for assessing cardiovascular disease mostly focus on measuring a given biomarker at a specific spatial location where an abnormality is suspected. However, as a result of the dynamic and complex nature of the cardiovascular system, the analysis of isolated biomarkers is generally not sufficient to characterize the pathological mechanisms behind a disease. Model-based approaches that integrate the mechanisms through which different components interact, and present possibilities for system-level analyses, give us a better picture of a patient’s overall health status. One of the main goals of cardiovascular modelling is the development of personalized models based on ...
