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Leading-edge Stem Cell Research
This book presents recent and important findings on stem cell research which is finding many applications including nervous system diseases, diabetes, heart disease, auto-immune diseases as well as Parkinson's disease, end-stage kidney disease, liver failure, cancer, spinal cord injury, multiple sclerosis and Alzheimer's disease. Stem cells are self-renewing, unspecialised cells that can give rise to multiple types all of specialised cells of the body. Stem cell research also involves complex ethical and legal considerations since they involve adult, foetal tissue and embryonic sources.
The Evolution and Development of the Antibody Repertoire
Although at first glance mechanisms used to create the variable domains of immunoglobulin appear to be designed to generate diversity at random, closer inspection reveals striking evolutionary constraints on the sequence and structure of these antigen receptors, suggesting that natural selection is operating to create a repertoire that anticipates or is biased towards recognition of specific antigenic properties. This Research Topics issue will be devoted to an examination of the evolution of antigen receptor sequence at the germline level, an evaluation of the repertoire in B cells from fish, pigs and human, an introduction into bioinformatics approaches to the evaluation and analysis of the repertoire as ascertained by high throughput sequencing, and a discussion of how study of the normal repertoire informs the construction or selection of in vitro antibodies for applied purposes.
Fluctuations and Order
The volume that you have before you is the result of a growing realization that fluctuations in nonequilibrium systems playa much more important role than was 1 first believed. It has become clear that in nonequilibrium systems noise plays an active, one might even say a creative, role in processes involving self-organization, pattern formation, and coherence, as well as in biological information processing, energy transduction, and functionality. Now is not the time for a comprehensive summary of these new ideas, and I am certainly not the person to attempt such a thing. Rather, this short introductory essay (and the book as a whole) is an attempt to describe where we are at present and how...
Biomat 2010 - International Symposium On Mathematical And Computational Biology
This volume contains the selected contributed papers of the BIOMAT 2010 International Symposium which has been organized as a joint conference with the 2010 Annual Meeting of the Society for Mathematical Biology (www.smb.org) by invitation of the Director Board of this Society. The works presented at Tutorial and Plenary Sessions by expert keynote speakers have been also included.This book contains state-of-the-art articles on special research topics on mathematical biology, biological physics and mathematical modelling of biosystems; comprehensive reviews on interdisciplinary areas written by prominent leaders of scientific research groups. The treatment is both pedagogical and sufficiently advanced to enhance future scientific research.
Biomat 2014 - International Symposium On Mathematical And Computational Biology
This is a book of a series on interdisciplinary topics on the Mathematical and Biological Sciences. The chapters correspond to selected papers on special research themes, which have been presented at BIOMAT 2014 International Symposium on Mathematical and Computational Biology which was held in the Stefan Banach International Mathematical Centre at Bedlewo near Poznan, Poland on November 03 - 07, 2014. The treatment is both pedagogical yet advanced in order to motivate research students as well as to fulfill the requirements of professional practitioners. As in the other volumes of this series, there are new important results on the interdisciplinary fields of mathematical and biological sciences and comprehensive reviews written by prominent scientific leaders of famous research groups.
Health and Cognition in Old Age
In recent years, the aim of research on aging has shifted from prolonging life to fostering healthy and cognitively robust old age. In order to improve the quality of life of older people, we need to better understand cognitive aging as well as bodily aging. Health and Cognition in Old Age assembles the cream of research across varied medical, mental health, and social disciplines, and demonstrates how this knowledge can lead to improved outcomes for older people. The first half of this expert volume discusses biomedical and life course factors in aging, particularly as they affect cognition and well-being in later life. From there, effective solutions are the focus: interventions and care p...
Comparative Immunoglobulin Genetics
This contemporary book covers significant new knowledge that has emerged during the last two decades and, thus, provides novel antibody phylogenetic perspectives relevant to development of new antibody-based therapeutics and vaccines. It fills a much-needed niche in the area of immunoglobulin genetics across species from a comparative perspective.
