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This text focuses not only on localized diseases caused by infectious diseases, trauma, tumours, and vascular lesions within the central nervous system, but also these diseases within the systems of the brain and spinal cord. Over 250 real cases with associated MRI or CTs and any pathological findings from these patients illustrate numerous disorders and fully explain the nature of the pathology.
Nine years have elapsed since the second edition of this book was published. In this time the principal advances in neuromuscular diseases have been in the application of molecular genetics to understanding the aetiology and pathogenesis of this group of disorders. As a result many previously unrecognised disorders have been charac terised. Some clinical syndromes, such as the limb girdle dystrophies, have become better defined. In many such instances the new genetic information has led to major advances in knowledge of the biology of cell structures, for example, the membrane structural and channel proteins. The clinical syndromes themselves, and their patho logical and electrophysiological...
While motor neuropathies and neuronopathies and mixed sensory-motor neuropathies have been met with adequate interest by clinical and basic researchers and physicians, pure sensory neuropathies and neuro nopathies have received comparably less attention, despite of the consider able morbidity they may cause in the individual patient. This prompted us to organize an International Symposium on Sensory Neuropathies which was held in Vienna, September 22-24,1990, as satellite to the International Neuromuscular Congress held one week earlier in Munich, Germany. We were fortunate to have a faculty of experienced authorities in the field as participants. This volume is the proceedings of the sympos...
This 1998 book was the first to be dedicated to peripheral neuropathies of immune or infectious origin, covering pathogenesis, diagnosis and treatment.
Building on the author's personal experience in working with fellows and residents in the electromyography laboratory, this volume is the definitive reference in the field. It is intended for clinicians who perform electrodiagnostic procedures as an extension of their clinical examination, and will be of value to neurologists and physiatrists who are interested in neuromuscular disorders and noninvasive electrodiagnostic methods, particularly those practicing electromyography (EMG). The book provides a comprehensive review of most peripheral nerve and muscle diseases, including specific techniques and locations for performing each test. Divided into two major sections, the first addresses th...
This book reviews the electrophysiological, genetic and immunological bases of some of the major neuromuscular diseases and evaluates their importance pertaining to the clinical management of the patients. Included are up-to-date topics such as gene therapy, myoblast transfer and new drug trials. Written by experts in their own fields, this volume will not only be of great value to neurologists and neuroscientists, but also to geneticists, immunologists and physiologists.
In writing this book, I have attempted to provide information about the relative value of particular investigations in various neurological disorders. The book is divided into sections dealing with the methods of investigation, the investigation of particular symptoms, the investigation of specific neurological conditions and neurological emergencies. Finally, the assessment of certain disorders suggesting a particular anatomical localization, for example isolated optic atro phy, is considered. Following an appraisal of the literature, each section ends with a recommendation regarding appropriate investigation. In some in stances this is supported by an algorithm. Specific recommendations ha...
More than for any other volume of the Handbook of Neurochemistry, the chap ters in this volume on Pathological Neurochemistry deal with the interface of the laboratory bench with the patient's bedside. Most of the chapters reflect the confluence of basic scientists, clinical investigators, and physicians. Con sidered here are many of the more important disorders that afflict the nerves, muscles, spinal cord, and/or brain of mankind throughout the world. There are well over 500 such disorders. And our understanding of their nature and of measures for effective prevention or treatment depends significantly on appli cation of the biochemical disciplines that characterize neurochemistry. Before ...
Since publication of the Third Edition in 1998, the understanding of the immune mechanisms underlying autoimmunity and autoimmune disease has significantly deepened and broadened. This Fourth Edition incorporates new material and combines common themes underlying inductive and effector mechanisms and therapies that relate generally to the autoimmune disorders. It discusses the biological basis of disease at genetic, molecular, cellular, and epidemiologic levels.New to This Edition:* Tissue-specific interventions to arrest or "cure" autoimmune disease* Bone marrow eradication and replacement* Both basic science and clinical medicine is covered* Boxed points to emphasize key features of each chapter