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Carbohydrate-based Drug Discovery
To exploit the full potential of this diverse compound class for the development of novel active substances, this handbook presents the latest knowledge on carbohydrate chemistry and biochemistry. While it is unique in covering the entire field, particular emphasis is placed on carbohydrates with pharmaceutical potential. Topics include the following: > Chemical Synthesis of Carbohydrates > Carbohydrate Biosynthesis and Metabolism > Carbohydrate Analysis > Cellular Functions of Carbohydrates > Development of Carbohydrate-based Drugs A premier resource for carbohydrate chemists and drug developers, this comprehensive two-volume work contains contributions by more than 50 of the world's leading carbohydrate chemists.
Carbohydrate-based Drug Discovery, 2 Volume Set
Die Suche nach Medikamenten mit neuen oder verbesserten Eigenschaften hat das Interesse am pharmazeutischen Potenzial von Kohlenhydraten enorm verstärkt. Dies gilt insbesondere für die Entwicklung von Antibiotika, Impfstoffen und Anti-Krebs-Mitteln. Carbohydrate-based Drug Discovery stellt mit mehr als 50 Beiträgen der weltweit führenden Experten die neuesten Entwicklungen in der Kohlenhydrat- und Biochemie vor. Dabei liegt der Schwerpunkt der Darstellung auf der pharmazeutischen Anwendung. In jüngster Zeit sind wirksame, auf Kohlenhydraten basierende Medikamente gegen HIV, Grippe, Epilepsie, Diabetes und Krebs auf den Markt gekommen bzw. werden in Studien klinisch erprobt. Doch das ges...
Natural Products Chemistry
Natural Products Chemistry, Volume 2 covers the introductory survey, history, structure, synthesis, reactions, and biosynthesis of natural products such as the fatty acid derivatives and related compounds; sugars (carbohydrates); carboaromatic and related compounds; alkaloids; and non-alkaloidal nitrogen compounds. The text also describes the aspects of natural products photochemistry.
Acoustics of Bangla Speech Sounds
This book presents the consolidated acoustic data for all phones in Standard Colloquial Bengali (SCB), commonly known as Bangla, a Bengali language used by 350 million people in India, Bangladesh, and the Bengali diaspora. The book analyzes the real speech of selected native speakers of the Bangla dialect to ensure that a proper acoustical database is available for the development of speech technologies. The acoustic data presented consists of averages and their normal spread, represented by the standard deviations of necessary acoustic parameters including e.g. formant information for multiple native speakers of both sexes. The study employs two important speech technologies:(1) text to speech synthesis (TTS) and (2) automatic speech recognition (ASR). The procedures, particularly those related to the use of technologies, are described in sufficient detail to enable researchers to use them to create technical acoustic databases for any other Indian dialect. The book offers a unique resource for scientists and industrial practitioners who are interested in the acoustic analysis and processing of Indian dialects to develop similar dialect databases of their own.
Time Domain Representation of Speech Sounds
The book presents the history of time-domain representation and the extent of its development along with that of spectral domain representation in the cognitive and technology domains. It discusses all the cognitive experiments related to this development, along with details of technological developments related to both automatic speech recognition (ASR) and text to speech synthesis (TTS), and introduces a viable time-domain representation for both objective and subjective analysis, as an alternative to the well-known spectral representation. The book also includes a new cohort study on the use of lexical knowledge in ASR. India has numerous official dialects, and spoken-language technology development is a burgeoning area. In fact TTS and ASR taken together constitute the most important technology for empowering people. As such, the book describes time domain representation in such a way that it can be easily and seamlessly incorporated into ASR and TTS research and development. In short, it is a valuable guidebook for the development of ASR and TTS in all the Indian Standard Dialects using signal domain parameters.
Strategies and Tactics in Organic Synthesis
Strategies and Tactics in Organic Synthesis, Volume 3 provides detailed accounts of interesting advances in the field of synthesis. This book discusses the tasks of multistep synthesis from finding the proper reagents, reaction, and conditions for individual steps to inventing new chemistry to fill gaps in existing synthetic methodology. Organized into 13 chapters, this volume begins with an overview of the development of redox glycosidation strategy through ester methylenation. This text then examines the development of computer-assisted molecular modeling with applications to a wide range of problems in biological and organic chemistry. Other chapters consider the medicinal significance of ginkgo tree, which has prompted systematic studies to correlate the claimed beneficial effects of its extracts to the active principles. This book discusses as well the biological potency of pentacyclic quassinoids. The final chapter deals with the economic synthesis of a penem antibacterial. This book is a valuable resource for chemists.
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Particle Physics
Stimulated by the Large Hadron Collider and the search for the elusive Higgs Boson, interest in particle physics continues at a high level among scientists and the general public. This book includes theoretical aspects, with chapters outlining the generation model and a charged Higgs boson model as alternative scenarios to the Standard Model. An introduction is provided to postulated axion photon interactions and associated photon dispersion in magnetized media. The complexity of particle physics research requiring the synergistic combination of theory, hardware and computation is described in terms of the e-science paradigm. The book concludes with a chapter tackling potential radiation hazards associated with extremely weakly interacting neutrinos if produced in copious amounts with future high-energy muon-collider facilities.
Speech, Sound and Music Processing: Embracing Research in India
This book constitutes the thoroughly refereed post-proceedings of the 8th International Symposium on Computer Music Modeling and Retrieval, CMMR 2011 and the 20th International Symposium on Frontiers of Research in Speech and Music, FRSM 2011. This year the 2 conferences merged for the first time and were held in Bhubanes, India, in March 2011. The 17 revised full papers presented were specially reviewed and revised for inclusion in this proceedings volume. The book is divided in four main chapters which reflect the high quality of the sessions of CMMR 2011, the collaboration with FRSM 2011 and the Indian influence, in the topics of Indian Music, Music Information Retrieval, Sound analysis synthesis and perception and Speech processing of Indian languages.
