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Immunoregulatory Mechanisms of Interferon
Interferons (IFN) belong to the family of cytokines and have been described first in the late 1950s as an inhibitory factor of viral replication. Since then, the impact of interferon has been greatly expanded and its function comprises a role not only in different types of infection, cancer and autoimmunity but importantly also in immunehomeostasis. IFN have important anti-viral effects but it is becoming more and more evident that they are true immunomodulators and have an important impact on the development and maintenance of innate and adaptive immunity.
Goodman's British Planemakers
This new edition of the classic reference British Planemakers from 1700 has been completely rewritten, with over 200 pages of new information. Online research tools haven enabled much greater insight into family connections of planemakers, family and business continuities, and the discovery of previously unknown planemakers. Confirmation that planemakers were working in the late 1600s, in fact, inspired the new edition’s title, Goodman’s British Planemakers. The biographic directory covers more than 2400 planemakers and includes 2250 maker's mark illustrations. Like its predecessors, the new edition traces the development of British planemaking, but far more extensively, now confirming that planemakers moved around the country to a much greater extent than previously realized, and identifying several new family planemaking dynasties. The book includes chapters on the planemaking trade and its practices, descriptions and illustrations of the many types of planes and their evolution, and provincial planemaking, as well as sections on apprentice records, trade marks, and a complete index. An absolutely invaluable reference.
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Birmingham
This is a detailed, authoritative, and easy-to-use guide to the architectural wealth of England's second city, the "workshop of the world." Birmingham's major buildings include its splendid English Baroque cathedral, pioneering Neo-Roman town hall, and still controversial Central Library of the 1970s. Streets of rich and varied Victorian and Edwardian architecture bear witness to an earlier era when Birmingham's civic initiatives were the admiration of the country. More recently, the city has been rejuvenated with architecture on a giant scale, including the iconoclastic Selfridges and the canalside precinct of Brindleyplace, where Modernism and Classical Revival are excitingly juxtaposed. The guide also explores a variety of outer districts and suburbs, among them the famous Jewellery Quarter, the stucco villas of Edgbaston, and Cadbury's celebrated Garden Suburb at Bournville. A connecting theme is provided by the local Arts and Crafts school, which flourished well into the twentieth century.
Nucleic Acid Sensing and Immunity - PART B
Nucleic Acid Sensing and Immunity - PART B, Volume 345 gives a comprehensive overview of the nucleic acid machinery, from plants to mammalians, along with their regulation. Chapters in this updated volume include Nucleic acids sensing in allergic disorders, Nucleic acids sensing in autoimmune disorders, Nucleic acid sensing in inflammatory disorders, Viral nucleic acid sensing inflammasomes in intestinal host defense, Genome damage sensing leads to tissue homeostasis in Drosophila, Nucleic acids sensing in plants, Nucleic Acid sensing in invertebrates, amongst other topics. - Provides an accurate, state-of-the-art resource on RNA sensing - Includes the work of a well-known tumor immunologist - Links intestinal host defense and viral nucleic acid sensing - Presents a chapter on the negative regulation of DNA sensing, a timely topic
