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Plasticity of GABAergic Synapses
Learning and memory are believed to depend on plastic changes of neuronal circuits due to activity-dependent potentiation or depression of specific synapses. During the last two decades, plasticity of brain circuits was hypothesized to mainly rely on the flexibility of glutamatergic excitatory synapses, whereas inhibitory synapses were assumed relatively invariant, to ensure stable and reliable control of the neuronal network. As a consequence, while considerable efforts were made to clarify the main mechanisms underlying plasticity at excitatory synapses, the study of the cellular/molecular mechanisms of inhibitory plasticity has received much less attention. Nevertheless, an increasing bod...
Molecular and Cellular Targets for Anti-epileptic Drugs
A new phase of anti-epileptic drugs (AEDs) investigation has begun in which new drugs can be designed to target specific epileptogenic mechanisms. A rational approach to therapy today requires not only a full awareness of phamacokinetics of AEDs but also a thorough knowledge of their molecular targets and of their influence on excitatory and inhibitory mechanisms in the brain. This book provides a multi-author systematic look at this subject, from neurobiological bases to clinical applications. It includes four sections dealing with fundamental aspects of cortical excitability, models of epileptic disorders, targets for anti-epileptic drugs and rational approaches to therapy. Each chapter provides a review of a specific topic prepared by well known scientists active in the field, introducing their most recent results in a concise and comprehensive form.
The Physics and Applications of High Brightness Electron Beams
This book contains the contributions to the Workshop on the Physics and Applications of High Brightness Electron Beams, held in July 2002 in Sardinia, Italy. This workshop had a broad international representation from the fields of intense electron sources, free-electron lasers, advanced accelerators, and ultra-fast laser-plasma, beam-plasma and laser-beam physics. The interdisciplinary participants were brought together to discuss advances in the creation and understanding of ultra-fast, ultra-high brightness electron beams, and the unique experimental opportunities in frontier high-energy-density and radiation-source physics which are offered by these scientific tools.The proceedings have been selected for coverage in: ? Index to Scientific & Technical Proceedings? (ISTP? / ISI Proceedings)? Index to Scientific & Technical Proceedings (ISTP CDROM version / ISI Proceedings)
Neutrotransmitter Release and Uptake
Even though transmitter release and re-uptake are very complementary and physically in close proximity, researchers usually focus on only one of these two aspects. This volume, however, covers both processes and brings together two major presynaptic events in transcellular communication. It comprises 24 chapters and is divided into two parts: Part I, Neurotransmitter Release, and Part II, Neurotransmitter Uptake. The included topics range from ultrastructure and molecular control mechanisms to pathophysiology of some diseased states. Neuronal as well as non-neuronal mechanisms are treated. The concluding chapter emphasizes the importance of interdisciplinary collaboration and provides a link between the events in the presynaptic terminal and behavior.
Philosophical Transactions
Each issue of Transactions B is devoted to a specific area of the biological sciences, including clinical science. All papers are peer reviewed and edited to the highest standards. Published on the 29th of each month, Transactions B is essential reading for all biologists.
