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La obra recoge los fundamentos del sistema de clasificación biofarmacéutica y su aplicación al desarrollo de medicamentos vía oral. Se describen las metodologías experimentales para el estudio de la permeabilidad, solubilidad, y velocidad de disolución. Incluye la descripción básica de la fisología gastrointestinal y de la absorción a través de la membrana intestinal así como los factores determinantes de la liberación del fármaco en lo fluidos gastrointestinales. La obra pretende ser un manual para el desarrollo preclínico y clínico de medicamentos innovadores o genéricos que permitan sustentar la solicitud de bioexenciones y la demostración de la bioequivalencia in vitro.
A drug policy is a crucial ingredient in every country's national health strategy as it provides a strategic framework to identify goals and commitments. This publication discusses the key components of such a policy. Issues covered include: the selection of essential drugs, affordability; finance and supply; regulation and quality assurance; rational use; research; human resources; monitoring and evaluation.
Entre el río y la montaña es el resultado de una investigación arqueológica sobre la ocupación temprana del Cauca medio colombiano, llevada a cabo en el sitio La Pochola, el cual forma parte de un grupo de sitios precerámicos localizados en esta región y datados entre los últimos momentos del Pleistoceno final y el Holoceno medio. El alto número de sitios reportados hasta el momento confirma que esta región fue clave en el poblamiento y dispersión de grupos humanos a lo largo de la Cordillera central. Probablemente, sus condiciones ecológicas y su posición estratégica de acceso a varios pisos altitudinales actuaron como atractores de poblaciones humanas, que encontraron las condiciones de vida para colonizar y ocupar esta región cordillerana. El origen de estos grupos sigue siendo desconocido.
This two-volume set LNCS 11590 and 11591 constitutes the refereed proceedings of the 6th International Conference on Learning and Collaboration Technologies, LCT 2019, held as part of the 21st International Conference on Human-Computer Interaction, HCII 2019, in Orlando, FL, USA in July 2019. The 1274 full papers and 209 posters presented at the HCII 2019 conferences were carefully reviewed and selected from 5029 submissions. The papers cover the entire field of human-computer interaction, addressing major advances in knowledge and effective use of computers in a variety of applications areas. The papers in this volume are organized in the following topical sections: designing and evaluating learning experiences; theoretical and pedagogical approaches in technology-enhanced learning; cognitive and psychological issues in learning; and technology in STEM education.
Vols. for 1982/1983- include : University of Illinois at Chicago. Health Sciences Center. Staff directory.
This two-volume set LNCS 11590 and 11591 constitutes the refereed proceedings of the 6th International Conference on Learning and Collaboration Technologies, LCT 2019, held as part of the 21st International Conference on Human-Computer Interaction, HCII 2019, in Orlando, FL, USA in July 2019. The 1274 full papers 209 posters presented at the HCII 2019 conferences were carefully reviewed and selected from 5029 submissions. The papers cover the entire field of human-computer interaction, addressing major advances in knowledge and effective use of computers in a variety of applications areas. The papers in this volume are organized in the following topical sections: mobile and ubiquitous learning; virtual reality and augmented reality systems for learning; and collaborative technology.
Since the publication of the first volume “Infrasound monitoring for atmospheric studies” published in 2010, significant advances were achieved in the fields of engineering, propagation modelling, and atmospheric remote sensing methods. The global infrasound network, which consists of the International Monitoring Network (IMS) for nuclear test ban verification completed by an increasing number of regional cluster arrays deployed around the globe, has evidenced an unprecedented potential for detecting, locating and characterizing various natural and man-made sources. In recent years, infrasound has evolved into a broad interdisciplinary field encompassing academic disciplines of geophysic...