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Cancer was thought to originate from alterations in intercellular signaling that resulted in the transformation of cells, their uncontrolled proliferation and metastasis. There is now an increasing body of evidence demonstrating that the surrounding matrix and cell-matrix interactions are also major players in this process. Cells adhere and receive signals from various extracellular matrices via transmembrane receptors, the best known of which are the heterodimeric glycoproteins, integrins.
With humor and empathy, Dana Brantley-Sieders explores the science and realities of breast cancer for the love of your boobs and your life. Dana Brantley-Sieders spent twenty years working as a biomedical breast cancer researcher. Then, she was diagnosed with breast cancer. She thought she knew breast cancer before it whacked her upside her left boob and left her bleeding on the curb of uncertainty. Turns out, she had a lot to learn. This book shares Brantley-Sieders’ personal journey with breast cancer, from the laboratory bench to her own bedside, and provides accessible information about breast cancer biology for non-scientists. Talking to My Tatas: All You Need to Know from a Breast Ca...
Thoroughly revised and updated, this Fourth Edition is the most comprehensive, current reference on lung cancer, with contributions from the world's foremost surgeons, radiation oncologists, medical oncologists, pulmonologists, and basic scientists. Coverage includes complete information on combined modality treatments for small cell and non-small cell lung cancer and on complications of treatment and management of metastases. Emphasis is also given to early detection, screening, prevention, and new imaging techniques. This edition has expanded thoracic oncology chapters including thymus, mesothelioma, and mediastinal tumors, more detailed discussion of targeted agents, and state-of-the-art information on newer techniques in radiotherapy. Other highlights include more international contributors and greater discussion of changes in lung cancer management in each region of the world. A new editor, Giorgio Scagliotti, MD from the University of Turin, has coordinated the accounts of European activities. A companion website includes the full text online and an image bank.
This collection aims to explore the transformative potential of computer vision and artificial intelligence (AI) in revolutionizing medical imaging. Medical imaging is still in a state of infancy. The interpretation of medical images is often time-consuming and subject to human error. By leveraging computer vision algorithms and AI technologies, medical imaging can be enhanced with automated analysis, pattern recognition, and predictive modelling, leading to improved accuracy, speed, and clinical outcomes. This collection provides an overview of the current state, challenges, and prospects of integrating computer vision and AI techniques into existing medical imaging technologies. Medical imaging has the potential to create a paradigm shift in healthcare in future enhancing diagnostic accuracy, personalised treatment, and overall patient care. While challenges related to data quality, interpretability, and ethics must be navigated, the future for AI based imaging technology is bright.
Extracellular matrix proteins are serious, common human diseases that are caused by mutations in genes that encode these proteins. This has spurred a great number of researchers to study the extracellular matrix, sometimes by choice and sometimes by necessity. Much progress has been made in the last decade towards understanding what matrix proteins do and how cells interact with and respond to them. Volume 15 is a compilation of reviews by experts in their respective fields. The chapters in this book address the biology of a broad spectrum of extracellular matrix molecules and their functions in development and disease. This book has been designed to focus on a diverse subset of matrix prote...
Angiogenesis describes the formation of new blood vessels, which arise as outgrowths from existing vessels. In many physiological processes such as ovulation and wound healing angiogenesis is involved for a relatively short time. Otherwise under normal physiological conditions in the adult organism angiogenesis is an extremely slow process. By contrast in certain disease states such as diabetic retinopathy, arthritis, chronic inflammation, hemangiomas, etc., angiogenesis persists and contributes to the pathology of these disease states. Some 50 such "angiogenic diseases" have been described where angiogeneSiS is involved. Also in tumor growth and metastasis angiogenesis is an essential proce...
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With contributions by a team of internationally respected scientists, this book provides up-to-date information on the extensively studied cytochrome P450 enzyme in a very accessible manner.
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