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First multi-year cumulation covers six years: 1965-70.
For practitioners at all stages of experience, diseases of the parathyroid glands are not easily deciphered. There are many subtleties to its pathology and diagnosis. Today, the wealth of new information from molecular medicine makes it very challenging for the individual practitioner to have a complete picture of these entities. Diseases of the Parathyroid Glands addresses these issues by offering a concise, user-friendly text that provides state-of-the-art background on mineral physiology and its regulation and couples this to a variety of clinical topics of parathyroid gland pathology. Introductory chapters cover calcium regulation and parathyroid gland physiology, drawing upon many of th...
The aim of these two volumes is to provide an up-to-date text about the developments in the field during the last 5 - 10 years. Authors with an outstanding record both as active investigators and as critical reviewers have been selected. The result is an integrated collection of contributions forming a fundamental reference work for undergraduate and graduate students, and for those involved in research and teaching in biochemistry and related subjects. Part I contains 15 papers dealing with general aspects of hormones and their actions.
Shaul G. Massry Division of Nephrology, The University of Southern California, School of Medicine Los Angeles, California In the last two decades evidence has accumulated indicating that parathyroid hormone may exert a multitude of effects on many cells and a variety of organs beyond its classical targets: the kidney and the bone. These efforts have been spearheaded by nephrologists. The interest of this group of clinicians-scientists stems from the fact that patients with renal failure have secondary hyperparathyroidism and markedly elevated blood levels of PTH (1,2). If this hormone does act on various organs, it becomes plausible that excess blood levels of PTH may be harmful in these pat...
Many advances in vitamin D physiology and biochemistry have been made in recent years. Vitamin D metabolites and analogs have found increasing application in clinical medicine. The purpose of this text is to review what is known about vitamin D physiology and draw attention to areas of vitamin D research that have changed within the last 2-3 years. Additionally, information concerning clinical aspects of vitamin D is also presented. More than 40 scientists have generously contributed chapters to this text; I thank them for their efforts. As might be expected, not everyone has the same point of view. Finally, I would like to acknowledge the secretarial and editorial efforts of Mrs. Cheryl Col...
Bone Drugs in Pediatrics brings together in one place the evidence for the use of certain drugs in the treatment and prevention of bone loss in children, as well as the reservations still present in the pediatric community regarding their use. Beginning with a discussion of developmental pharmacokinetics and drug development for pediatric diseases where bone loss occurs, such as osteogenesis imperfecta, the physiology of pediatric bone and how best to monitor the safety and efficacy of these drugs is presented. The pros and cons of utilizing the drugs themselves – such as bisphosphonates, antiresorptives and anabolic agents – within the pediatric population are carefully considered, with an eye toward safe and effective integration. The potential use of drugs in future treatment is also highlighted. On the whole, Bone Drugs in Pediatrics is a cogent presentation of the ongoing debate surrounding the potential for pharmacological interventions in pediatric bone loss.