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Wound Healing
Skin wounds are common occurrences that result from the breakdown of anatomical continuity and integrity of the epidermis, with consequent functional changes. Wound healing is a complex phenomenon through which there is healing of the skin. The wound healing process begins immediately after the wound occurs and can be a lengthy and complex process depending on the severity of the wound and the normal or abnormal healing progress. Wound healing progress through three distinct phases of inflammation, proliferation, and remodeling in a methodical and complex sequence that involves cellular, molecular, and humoral mechanisms of action. Any change in this sequence of events can lead to abnormal w...
Peripheral Nerve Regeneration
Peripheral nerve injuries are a high-incidence clinical problem that greatly affects patients' quality of life. Despite continuous refinement of microsurgery techniques, peripheral nerve repair still stands as one of the most challenging tasks in neurosurgery, as functional neuromuscular recovery is rarely satisfactory in these patients. Therefore, the improvement of surgical techniques and the clinical application of innovative therapies have been intensively studied worldwide. Direct nerve repair with epineural end-to-end sutures is still the gold standard treatment for severe neurotmesis injuries but only in cases where well-vascularized tension-free coaptation can be achieved. When perip...
Metabolomics
Metabolomics: Fundamentals and Applications authoritatively presents the basic principles and applications of metabolomics. Topics covered in this book range from the analysis of metabolites from different biological sources and their data processing and statistical analysis. This book serves as a basic guide for a wide range of audiences from less familiar with metabolomics techniques to more experienced researchers seeking to understand complex biological systems from the systems biology approach.
Scaffolds in Tissue EngineeringMaterials, Technologies and Clinical Applications
Biomaterials are often designed to act as scaffolds, i.e., 3D porous templates that support and stimulate the growth of healthy tissue and then safely dissolve once they have performed their functions. This book provides a picture of the current state of the art in the field of scaffolds for tissue engineering, highlighting the potential associated to the latest scientific and technological advancements. The former part of the book focuses on the repair of "hard" tissues (primarily bone) by means of bioceramic/glass scaffolds, and the latter deals with the applications of polymeric scaffolds for regenerating "soft" tissues and structures including the peripheral nerve, heart, gastric mucosa and pancreas. Special emphasis is given to the challenges associated to scaffold manufacturing, biomimetic properties and cell-scaffold interactions.
Umbilical Cord Blood Banking for Clinical Application and Regenerative Medicine
Umbilical cord blood (UCB) and, more recently, umbilical cord tissue (UCT) have been stored cryopreserved in private and public cord blood and tissue banks worldwide, since the umbilical cord blood was used for the first time in a child with Fanconi anemia with his HLA-identical sibling, following strict guidelines that imply high-quality standards and total rastreability of these units. The hematopoietic stem cells (HSCs) are clinically used in hematopoietic treatments for blood disorders and hemato-oncological diseases. Also, the mesenchymal stem cells (MSCs) isolated from the UCT and UCB, nowadays, can be used as coadjuvants of hematopoietic transplants. In the near future, these stem cel...
Biomaterials
This contribution book collects five among reviews and original articles from eminent experts working in the interdisciplinary area of biomaterial synthesis and application. From their direct and recent experience, the readers can access the novel and ongoing potentialities of different synthetic and engineered biomaterials. Contributions reflect the fundamental studies, with a particular attention to the physico-chemical mechanical characterization of biomaterials, along with biocompatibility studies and potential clinical use. After an introductory chapter on the question of storage stability for biomaterial-based devices and products and for polymeric nanomedicines, a first review deals w...
Novel Perspectives of Stem Cell Manufacturing and Therapies
In the 1950s, Nobel Prize winner Dr. E. Donnall Thomas was the first to successfully transplant hematopoietic stem cells. Since then, studies on stem cells have evolved and expanded worldwide. There are more than 650,000 scientific publications on stem cells and more than 8000 stem cell clinical trials. This book summarizes types of stem cells, key studies, ongoing trials, and future perspectives. It also includes ethical, formal, and legal aspects to give the reader a comprehensive view of the field.
Peripheral Neuropathy
Peripheral Neuropathy offers an update on few of the hottest topics of diagnose, treatment and rehabilitation of peripheral nerve injuries. The book is composed of five chapters, each addressing a different topic, ranging from an analysis of the heightened risk of peripheral nerve injury in todays modern societies and what this signifies for the need in taking decisive action to prevent an increase in the numbers of disabled people, to the description of surgical procedures in pediatric patients. The role of regenerative medicine, the development of novel rehabilitative strategies, and the importance of peripheral neuropathy in diabetes are additional topics covered in the book. By reading this book the reader will be offered a general overview of current research and clinical practice in peripheral neuropathys field.
Mesenchymal Stem Cells
Mesenchymal Stem Cells: Isolation, Characterization, and Applications thoroughly presents the isolation, characterization, and some applications of mesenchymal stem cells in the clinic. The book has two parts: "Isolation and Characterization" and "Clinical Perspectives and Applications." In Part I, the subsequent chapters introduce some techniques in isolation, characterization, and purification of mesenchymal stem cells in different tissues. In Part II, some applications of mesenchymal stem cells in the popular diseases, which include cartilage regeneration, spinal cord injury, and osteoarthritis, are discussed. This book provides a succinct yet comprehensive overview of mesenchymal stem cells for advanced students, graduate students, and researchers.
